BUB1_SCHPO - dbPTM
BUB1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BUB1_SCHPO
UniProt AC O94751
Protein Name Checkpoint serine/threonine-protein kinase bub1
Gene Name bub1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1044
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Associates with kinetochores and centromeres during the early stages of mitosis.
Protein Description Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3..
Protein Sequence MSDWRLTENVLDQNIPETKPRESKTRLEEIQRLALFQEELDIIEELDDPVDVWYRCIEWLLETRFLGMETVNKMLDDAIQYLERCRFALNDVRHLLIQLAKIKQSYETPDELQQAAKQFYQLASKGIGLELALFYEEYGSLLIRMQRWKEASEVFHAAVSREARPLVRLLRNAAEFSRAYDLHNAHPSIHDAPYSSPFPPPRIVLGSKPVSSSTLPSKPKSFQVFSDASSSRDSQNASDLPQAKSLESEANTPNLPLLYDKSSGKRVEYSAFNFLALYENGEERSMEECRAQRYLSSIQPNTAASFPKVVPKNEISVHHDSSSSNVSPIYKNPVAEQSDTPTRSLPKNYAYVAKSTSPELKVFDTVMPVALSPKPAQKPPSPTIHTKAALADILDIFNQPLRSESLEKSSKSPISAQSSYLGTPLKNDENSSNSGATSLTGRSQEEHLDFIPSLTPSKNYPSKIYSPNKNLDFSHTASKAETYKNSNELENVKREQPFSELLPSTLQEETATGTTSTTFANAKRRPEDSNISPTNPKKLHTLPRSPQYSTVDSNSVLSPAMPKGYMFVNENQSMKHESSVSNPVATIPHENGKHDFGQLSPIEHKPFFPKNDDELPGPSGYLTMPYEEAMASLSNLPTLINPLDQSLRDLLFQVLRPSLLRDKDYHEHETSFALVEHIESFVSKIKPKAGGPGRRRSSNRHSLDGPEFHLFYPPNTNLSVISKLGQGAFAPVYLVKSKIETENGDVSQGGAENNESKLFALKIETPPSCFEFYLTRQAMTRLKGLRETNSILPVHQLHMFHDTSHLLMDYRPQGSILDLVNSMHNSTFSSSGMDEILVVFFSIEFLRIIEALHTHKIIHGDLKADNALLRLETVADSEWSPIYSPEGLYGWSFKGIYLIDFGRGIDLSLFEEKVKFIADWDTDLQDCIEMREGRPWTYQIDYHGLAAIIYTMLFGQYIETRIEVINGQRRQVLTQRMKRYWNQDLWHRLFDLLLNPTLHVSEENLPMTEELSKIRIEMEEWLVNHSTGGSGLKGLLKSIEKRKI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
221PhosphorylationTLPSKPKSFQVFSDA
CCCCCCCEEEEECCC		29.4629996109
226PhosphorylationPKSFQVFSDASSSRD
CCEEEEECCCCCCCC		33.1529996109
245PhosphorylationSDLPQAKSLESEANT
HHCHHHHHHHHHCCC		40.1425720772
316PhosphorylationVVPKNEISVHHDSSS
CCCCCCEEEECCCCC		14.8224763107
321PhosphorylationEISVHHDSSSSNVSP
CEEEECCCCCCCCCC		27.9724763107
322PhosphorylationISVHHDSSSSNVSPI
EEEECCCCCCCCCCC		43.7921712547
323PhosphorylationSVHHDSSSSNVSPIY
EEECCCCCCCCCCCC		29.8625720772
324PhosphorylationVHHDSSSSNVSPIYK
EECCCCCCCCCCCCC		43.1025720772
327PhosphorylationDSSSSNVSPIYKNPV
CCCCCCCCCCCCCCC		15.1621712547
330PhosphorylationSSNVSPIYKNPVAEQ
CCCCCCCCCCCCCCC		14.2221712547
338PhosphorylationKNPVAEQSDTPTRSL
CCCCCCCCCCCCCCC		34.6521712547
340PhosphorylationPVAEQSDTPTRSLPK
CCCCCCCCCCCCCCC		31.6329996109
342PhosphorylationAEQSDTPTRSLPKNY
CCCCCCCCCCCCCCE		34.6824763107
355PhosphorylationNYAYVAKSTSPELKV
CEEEEECCCCCCCCE		25.1225720772
356PhosphorylationYAYVAKSTSPELKVF
EEEEECCCCCCCCEE		47.8225720772
357PhosphorylationAYVAKSTSPELKVFD
EEEECCCCCCCCEEC		24.3825720772
365PhosphorylationPELKVFDTVMPVALS
CCCCEECEEECCCCC		13.7721712547
372PhosphorylationTVMPVALSPKPAQKP
EEECCCCCCCCCCCC		22.5724763107
381PhosphorylationKPAQKPPSPTIHTKA
CCCCCCCCCCCCHHH		43.1121712547
383PhosphorylationAQKPPSPTIHTKAAL
CCCCCCCCCCHHHHH		29.7221712547
386PhosphorylationPPSPTIHTKAALADI
CCCCCCCHHHHHHHH		20.6624763107
403PhosphorylationIFNQPLRSESLEKSS
HHCCCCCHHHHHHHC		38.9421712547
405PhosphorylationNQPLRSESLEKSSKS
CCCCCHHHHHHHCCC		42.9721712547
412PhosphorylationSLEKSSKSPISAQSS
HHHHHCCCCCCCCCC		29.4324763107
415PhosphorylationKSSKSPISAQSSYLG
HHCCCCCCCCCCCCC		24.5224763107
453PhosphorylationEHLDFIPSLTPSKNY
HHHCCCCCCCCCCCC		39.8129996109
455PhosphorylationLDFIPSLTPSKNYPS
HCCCCCCCCCCCCCC		29.8329996109
457PhosphorylationFIPSLTPSKNYPSKI
CCCCCCCCCCCCCCC		28.4429996109
466PhosphorylationNYPSKIYSPNKNLDF
CCCCCCCCCCCCCCC		26.0129996109
529PhosphorylationAKRRPEDSNISPTNP
CCCCCCCCCCCCCCC		34.1121712547
532PhosphorylationRPEDSNISPTNPKKL
CCCCCCCCCCCCCCC		29.8924763107
534PhosphorylationEDSNISPTNPKKLHT
CCCCCCCCCCCCCCC		58.3125720772
541PhosphorylationTNPKKLHTLPRSPQY
CCCCCCCCCCCCCCC		49.2224763107
545PhosphorylationKLHTLPRSPQYSTVD
CCCCCCCCCCCCCCC		17.8928889911
548PhosphorylationTLPRSPQYSTVDSNS
CCCCCCCCCCCCCCC		15.0821712547
549PhosphorylationLPRSPQYSTVDSNSV
CCCCCCCCCCCCCCC		19.3921712547
550PhosphorylationPRSPQYSTVDSNSVL
CCCCCCCCCCCCCCC		24.3315525673
553PhosphorylationPQYSTVDSNSVLSPA
CCCCCCCCCCCCCCC		27.0321712547
558PhosphorylationVDSNSVLSPAMPKGY
CCCCCCCCCCCCCCE		14.4124763107
600PhosphorylationKHDFGQLSPIEHKPF
CCCCCCCCCCCCCCC		18.8824763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BUB1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BUB1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BUB1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KLP5_SCHPOklp5genetic
11870212
KLP6_SCHPOklp6genetic
11870212
SWI6_SCHPOswi6genetic
9864354
BGS1_SCHPObgs1genetic
15146064
SWI6_SCHPOswi6genetic
14730319
SGO2_SCHPOsgo2genetic
14730319
BUB3_SCHPObub3physical
15509783
MAD3_SCHPOmad3physical
15525673
BUB3_SCHPObub3physical
15525673
DAD2_SCHPOdad2genetic
18632983
TBG_SCHPOgtb1genetic
17277378
YK12_SCHPOscm3genetic
12719471
SIM3_SCHPOsim3genetic
12719471
ARPC3_SCHPOarc3genetic
20668161
MPH1L_SCHPOmph1genetic
22281223
BUB3_SCHPObub3physical
22660415
MPH1L_SCHPOmph1genetic
22825872
MAD1_SCHPOmad1physical
22825872
MAD2_SCHPOmad2physical
22825872
MAD3_SCHPOmad3physical
22825872
BUB3_SCHPObub3physical
22825872
MAD3_SCHPOmad3physical
23695164
BUB1_SCHPObub1physical
23695164
POT1_SCHPOpot1genetic
24469396
BUB1_SCHPObub1physical
26771498
MAD3_SCHPOmad3physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BUB1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-550, AND MASSSPECTROMETRY.

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