| UniProt ID | SIM3_SCHPO | |
|---|---|---|
| UniProt AC | Q9USQ4 | |
| Protein Name | NASP-related protein sim3 | |
| Gene Name | sim3 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 396 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Histone H3 and H3-like CENP-A-specific chaperone. Promotes delivery and incorporation of CENP-A in centromeric chromatin, probably by escorting nascent CENP-A to CENP-A chromatin assembly factors. Required for central core silencing and normal chromosome segregation.. | |
| Protein Sequence | MSSDTKTLENSKGNSATDADTKNPSSSDSRAIEQLVTQGNMAYAQKNYEEAVDKYGQALMQSESIHGSESLENRNVLWLYGKSLFQIAIENSQVLGNALGAKESVSQATESFEEPEAIGSFTFSGQKIENKYTVNEENSSIAHPEKESEEKETNEASPASEEDEDDFNVAWEVLDLTRVMQSKAVDAYPDSKDEKIRLADIYDLLGELSLEIENFSQASQDLKTALEWKEKVYNVSNNTLLSEAHYKLALALEFTNPEDPSNKSRACEHVEKAAEILKNVLNERENEVTDKKGKGKQKAEESTLTSDLENLREMLSELEQKTLDLKHGAPSLEEAVMSKMHESSLLSKDSSSLAQAVAEAVKNANDLGGLVKRKRTKQEVTSSSQKEGPKDKKKKD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 109 | Phosphorylation | KESVSQATESFEEPE HHHHHHHCCCCCCCC | 25.24 | 25720772 | |
| 120 | Phosphorylation | EEPEAIGSFTFSGQK CCCCCCEEEEECCCE | 18.26 | 27738172 | |
| 132 | Phosphorylation | GQKIENKYTVNEENS CCEEECEEECCCCCC | 27.74 | 24763107 | |
| 133 | Phosphorylation | QKIENKYTVNEENSS CEEECEEECCCCCCC | 20.61 | 24763107 | |
| 140 | Phosphorylation | TVNEENSSIAHPEKE ECCCCCCCCCCCCHH | 35.06 | 21712547 | |
| 153 | Phosphorylation | KESEEKETNEASPAS HHCCCCCCCCCCCCC | 49.80 | 21712547 | |
| 157 | Phosphorylation | EKETNEASPASEEDE CCCCCCCCCCCCCCC | 18.15 | 21712547 | |
| 160 | Phosphorylation | TNEASPASEEDEDDF CCCCCCCCCCCCCCH | 44.92 | 21712547 | |
| 343 | Phosphorylation | VMSKMHESSLLSKDS HHHHHHHHHHCCCCH | 16.17 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SIM3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SIM3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SIM3_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SIM4_SCHPO | sim4 | genetic | 12719471 | |
| MIS6_SCHPO | mis6 | genetic | 12719471 | |
| YK12_SCHPO | scm3 | genetic | 12719471 | |
| CENPA_SCHPO | cnp1 | genetic | 12719471 | |
| CENPA_SCHPO | cnp1 | physical | 18158900 | |
| H31_SCHPO | hht3 | physical | 18158900 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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