SGO2_SCHPO - dbPTM
SGO2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SGO2_SCHPO
UniProt AC O13734
Protein Name Shugoshin-2
Gene Name sgo2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 647
Subcellular Localization Chromosome, centromere . Localizes to the centromere. Bub1 is required for centromeric localization (PubMed:14730319). At the onset of anaphase I, Sgo1 decreases markedly (PubMed:14730319).
Protein Description Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis..
Protein Sequence MSKASLSPNVEDLKKKQIRQYKEIIRISKAQSIRIKELQLENERLLSENIDLRTTAINLEEQLETVQNENEENKTKLAALLNRFHEETDNFLSKLSLCQQEIQDTFKPVEANLAYDVDTDSEDLDEESVVKDTEEIIEQAQHDVSLRNLSGIEDENIIDDGETAINEQKKREANVFSDTQSAPQLKSGKALPADFENPYNLSNSKPVNNNNEDRVEAVTSENKSIDSAPQEKNHEYEIVSPKSLSNKINNQAAAQRRTEEDNANGVAQEENEGSQEAHFHSRIQSDTVIQSTPTKRKWDVDIQNKQINLASAATNVTGYVSETDSRPNRANSLDSAVLLVQSSNKSNRNGHHISDPNLNSSISLKFAPEDTAHNSLTSQENVGPQVTTTSLSNMTVAESPRTDTPREINGLVDSSVTNGNEKFSVEIMNDSNKIGLNPKSFTDEEREILTLFRNPPMRLSSEPPSSNGFSIAHPNNSPLRPPSLQGILNAEDRPYEIEPSRSSFATNDTGSYNNLELLSSVTNLKSPNENDRVTKTQSRRETKVKRRRKARIQETSEESTVVNEPNEKPDGRSRRERKKVNYALPGLRTKLRRNFDLPSDHVKAKKTRRAPKNSENDSATKTETANITSEAPTTSEVTLENSETLNL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSKASLSPN
------CCCCCCCCC		36.6124763107
5Phosphorylation---MSKASLSPNVED
---CCCCCCCCCHHH		32.8721712547
7Phosphorylation-MSKASLSPNVEDLK
-CCCCCCCCCHHHHH		16.3728889911
28PhosphorylationYKEIIRISKAQSIRI
HHHHHHHHHHHHCEE		16.4628889911
32PhosphorylationIRISKAQSIRIKELQ
HHHHHHHHCEEEEHH		20.7728889911
145PhosphorylationEQAQHDVSLRNLSGI
HHHHHHHHHHCCCCC		27.8929996109
150PhosphorylationDVSLRNLSGIEDENI
HHHHHCCCCCCCCCC		41.0729996109
240PhosphorylationNHEYEIVSPKSLSNK
CCCEEECCCHHHHHH		32.0728889911
285PhosphorylationHFHSRIQSDTVIQST
HHHHHHCCCCEEECC		32.6429996109
287PhosphorylationHSRIQSDTVIQSTPT
HHHHCCCCEEECCCC		25.4229996109
291PhosphorylationQSDTVIQSTPTKRKW
CCCCEEECCCCCCCC		25.8229996109
292PhosphorylationSDTVIQSTPTKRKWD
CCCEEECCCCCCCCC		20.7128889911
294PhosphorylationTVIQSTPTKRKWDVD
CEEECCCCCCCCCEE		43.5029996109
332PhosphorylationSRPNRANSLDSAVLL
CCCCCCCCCCEEEEE		32.3528889911
335PhosphorylationNRANSLDSAVLLVQS
CCCCCCCEEEEEEEC		26.1028889911
395PhosphorylationTTSLSNMTVAESPRT
EEECCCCEECCCCCC		22.3327738172
399PhosphorylationSNMTVAESPRTDTPR
CCCEECCCCCCCCCH		15.2229996109
402PhosphorylationTVAESPRTDTPREIN
EECCCCCCCCCHHHC		47.8327738172
519PhosphorylationYNNLELLSSVTNLKS
CCHHHHHHHHHCCCC		35.0729996109
520PhosphorylationNNLELLSSVTNLKSP
CHHHHHHHHHCCCCC		32.6929996109
522PhosphorylationLELLSSVTNLKSPNE
HHHHHHHHCCCCCCC		36.4629996109
526PhosphorylationSSVTNLKSPNENDRV
HHHHCCCCCCCCCCC		35.8024763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SGO2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SGO2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SGO2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BIR1_SCHPObir1physical
17301288
BIR1_SCHPObir1physical
17322402
BIR1_SCHPObir1physical
20739936
SWI6_SCHPOswi6genetic
18818364
ABP1_SCHPOcbp1genetic
18818364
BYR2_SCHPObyr2genetic
18818364
CLR4_SCHPOclr4genetic
18818364
TAS3_SCHPOtas3genetic
18818364
RIK1_SCHPOrik1genetic
18818364
SDC1_SCHPOsdc1genetic
18818364
AGO1_SCHPOago1genetic
18818364
ELP2_SCHPOelp2genetic
18818364
RAF2_SCHPOraf2genetic
18818364
COPE_SCHPOsec28genetic
18818364
RIK1_SCHPOrik1genetic
22681890
TPP1_SCHPOtpp1genetic
22681890
NU132_SCHPOnup132genetic
22681890
SWI6_SCHPOswi6genetic
22681890
RAF2_SCHPOraf2genetic
22681890
CLR4_SCHPOclr4genetic
22681890
YE08_SCHPOSPAC17H9.08genetic
22681890
MUG20_SCHPOmug20genetic
22681890
HASP_SCHPOhrk1genetic
22681890
POF3_SCHPOpof3genetic
22681890
RAF1_SCHPOraf1genetic
22681890
PDS5_SCHPOpds5genetic
22681890
PDS5_SCHPOpds5physical
20929775
SWI6_SCHPOswi6physical
20929775
SGO2_SCHPOsgo2physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SGO2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-240; THR-292;SER-332 AND SER-335, AND MASS SPECTROMETRY.

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