NUF2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NUF2_SCHPO
• UniProt AC: Q10173
• Protein Name: Kinetochore protein nuf2
• Gene Name: nuf2
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 441
• Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Associated with kinetochores.
• Protein Description: Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity..
• Protein Sequence: MARKHTFPSLKRAEILECIDGLGIPFTAKELDQPTSKAVIPLYEEFLDLFMGLTRQNLEEKVNSLQDSVENFEIIHESLRFTVFYQILSQFMQNICFHDFTIQDLLKPDRNRLQLILSAVINFAKLREERLQQFDDDIQKRESLLETYTLLDAQRKDLEEKVLLSQDRKLESEAIIKQNEERNEEMFQSLIEDKRLCSQVRTEYDRIRMEASELKIRYHNVDSLMASTLEEIEKLQSSIVHSPEKLKGKIADTSLRIQNDRSQQVELDKKSKILHTKLNSLQLIEGDLNACLKVLEECLVELDKLEHATVLLSTNQELCDQIEINKKKLEFRKEQLLKQLSNAQEKLEHEQHSRNQKLEAAKQRMDNIREEYKVITQERNKKIQETEKKNAMIEMTEQKIAGMREELESQISSITMEFEKLKSHVELYIAELLRNLRSSNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Phosphorylation	DDIQKRESLLETYTL HHHHHHHHHHHHHHH	42.14	28889911
237	Phosphorylation	EEIEKLQSSIVHSPE HHHHHHHHHCCCCHH	32.25	29996109
238	Phosphorylation	EIEKLQSSIVHSPEK HHHHHHHHCCCCHHH	18.70	25720772
242	Phosphorylation	LQSSIVHSPEKLKGK HHHHCCCCHHHHCCC	24.70	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NUF2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NUF2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NUF2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUF2_SCHPO	nuf2	physical	15728720
NDC80_SCHPO	ndc80	physical	15728720
SPC24_SCHPO	spc24	physical	16079914
MIS13_SCHPO	mis13	physical	16079914
SPC7_SCHPO	spc7	physical	16079914
MIS14_SCHPO	mis14	physical	16079914
MIS12_SCHPO	mis12	physical	16079914
SPC25_SCHPO	spc25	physical	16079914
NDC80_SCHPO	ndc80	physical	16079914
PHD1_SCHPO	hos2	genetic	17352737
BUB3_SCHPO	bub3	genetic	19846658
ALP7_SCHPO	alp7	physical	23770679

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-242, ANDMASS SPECTROMETRY.
PubMed: 18257517