dbPTM

MIS12_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MIS12_SCHPO
UniProt AC	Q9Y738
Protein Name	Centromere protein mis12
Gene Name	mis12
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	259
Subcellular Localization	Chromosome, centromere . Chromosome, centromere, kinetochore .
Protein Description	Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Required for correct segregation of chromosomes and for maintaining the inner centromere structure..
Protein Sequence	MLVELLEFTPLSFIDDVINITNQLLYKGVNGVDKAFSQTRFAKKAPQEIEEGLHKFEVLFESVVDRYYDGFEVYTLRNIFSYPPELKGYMRTFGKDVDYSITTEQDAAMDQAIQEAAEKLVVKMQLRRDLRMRLSRKREKKTEIEKHLERISFLNKVPENWQVTLPETTDFLLDQLGNLQHAVKRVVEASPTVHSREVDERITYLEKGYERLSNPIDQQKDFWSHHLSKLESTANTETANNIHKLLLSSEKDVGHTDEP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
190	Phosphorylation	VKRVVEASPTVHSRE HHHHHHHCCCCCCHH	13.96	28889911
192	Phosphorylation	RVVEASPTVHSREVD HHHHHCCCCCCHHHH	28.49	28889911
213	Phosphorylation	EKGYERLSNPIDQQK HHHHHHCCCCCHHHH	46.94	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MIS12_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MIS12_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MIS12_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EKC1_SCHPO	ekc1	genetic	12773390
PPE1_SCHPO	ppe1	genetic	12773390
GSK3_SCHPO	gsk3	genetic	12773390
AMS2_SCHPO	ams2	genetic	12535531
SPC7_SCHPO	spc7	genetic	15502821
MIS13_SCHPO	mis13	genetic	15502821
NST1_SCHPO	SPAC29E6.10c	genetic	15502821
GSK3_SCHPO	gsk3	genetic	15502821
MIS14_SCHPO	mis14	genetic	15502821
MIS14_SCHPO	mis14	genetic	15369671
ABP1_SCHPO	cbp1	genetic	17004072
NUF2_SCHPO	nuf2	physical	15728720
NUF2_SCHPO	nuf2	physical	16079914
SPC24_SCHPO	spc24	physical	16079914
MIS13_SCHPO	mis13	physical	16079914
SPC7_SCHPO	spc7	physical	16079914
MIS14_SCHPO	mis14	physical	16079914
SPC25_SCHPO	spc25	physical	16079914
NDC80_SCHPO	ndc80	physical	16079914
MSC1_SCHPO	msc1	genetic	17947424
H2AZ_SCHPO	pht1	genetic	17947424
PHD1_SCHPO	hos2	genetic	17352737
YK12_SCHPO	scm3	genetic	12719471
CENPA_SCHPO	cnp1	genetic	12719471
SIM3_SCHPO	sim3	genetic	12719471
SIM4_SCHPO	sim4	genetic	12719471
YGI4_SCHPO	san1	genetic	21324894
NDC80_SCHPO	ndc80	physical	21445296
FTA2_SCHPO	fta2	physical	21445296
MIS6_SCHPO	mis6	physical	21445296
MIS17_SCHPO	mis17	physical	21445296
DAD1_SCHPO	dad1	physical	21445296
SAR1_SCHPO	sar1	physical	21445296
PRP19_SCHPO	prp19	physical	21445296
MIS15_SCHPO	mis15	physical	21445296
FTA7_SCHPO	fta7	physical	21445296
FTA6_SCHPO	fta6	physical	21445296
FTA4_SCHPO	fta4	physical	21445296
DIS1_SCHPO	dis1	genetic	16920624
SOS7_SCHPO	sos7	genetic	22711988

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MIS12_SCHPO

Related Literatures of Post-Translational Modification