KAPR_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAPR_SCHPO
• UniProt AC: P36600
• Protein Name: cAMP-dependent protein kinase regulatory subunit
• Gene Name: cgs1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 412
• Protein Sequence: MSFEEVYEELKALVDEQNPSDVLQFCYDFFGEKLKAERSVFRRGDTITESFSDGDESDFLSELNDMVAGPEAIGPDAKYVPELGGLKEMNVSYPQNYNLLRRQSVSTESMNPSAFALETKRTFPPKDPEDLKRLKRSVAGNFLFKNLDEEHYNEVLNAMTEKRIGEAGVAVIVQGAVGDYFYIVEQGEFDVYKRPELNITPEEVLSSGYGNYITTISPGEYFGELALMYNAPRAASVVSKTPNNVIYALDRTSFRRIVFENAYRQRMLYESLLEEVPILSSLDKYQRQKIADALQTVVYQAGSIVIRQGDIGNQFYLIEDGEAEVVKNGKGVVVTLTKGDYFGELALIHETVRNATVQAKTRLKLATFDKPTFNRLLGNAIDLMRNQPRARMGMDNEYGDQSLHRSPPSTKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFEEVYEE ------CCHHHHHHH	41.17	19547744
50	Phosphorylation	RGDTITESFSDGDES CCCCEEECCCCCCHH	22.77	29996109
52	Phosphorylation	DTITESFSDGDESDF CCEEECCCCCCHHHH	50.38	29996109
57	Phosphorylation	SFSDGDESDFLSELN CCCCCCHHHHHHHHH	38.10	29996109
61	Phosphorylation	GDESDFLSELNDMVA CCHHHHHHHHHHHHC	39.78	29996109
104	Phosphorylation	YNLLRRQSVSTESMN CCCCCCCCCCCCCCC	19.07	28889911
106	Phosphorylation	LLRRQSVSTESMNPS CCCCCCCCCCCCCHH	31.53	29996109
107	Phosphorylation	LRRQSVSTESMNPSA CCCCCCCCCCCCHHH	29.89	29996109
109	Phosphorylation	RQSVSTESMNPSAFA CCCCCCCCCCHHHHH	24.77	29996109
113	Phosphorylation	STESMNPSAFALETK CCCCCCHHHHHHHCC	30.89	28889911
406	Phosphorylation	GDQSLHRSPPSTKA- CCCCCCCCCCCCCC-	30.34	25720772
409	Phosphorylation	SLHRSPPSTKA---- CCCCCCCCCCC----	46.02	25720772
410	Phosphorylation	LHRSPPSTKA----- CCCCCCCCCC-----	36.44	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAPR_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAPR_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAPR_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEI3_SCHPO	mei3	genetic	12664134
NU184_SCHPO	nup184	genetic	10388805
TUP12_SCHPO	tup12	genetic	11238405
HAP5_SCHPO	php5	genetic	11238405
PYP1_SCHPO	pyp1	genetic	20453258
KAPB_SCHPO	pka1	physical	21869531
KAPB_SCHPO	pka1	physical	21879336
SAK1_SCHPO	sak1	genetic	7862141
RST2_SCHPO	rst2	genetic	10982411
STE11_SCHPO	ste11	genetic	10982411
KAPR_SCHPO	cgs1	physical	23695164
KAPR_SCHPO	cgs1	physical	26771498
IMA2_SCHPO	imp1	physical	26771498
YNY5_SCHPO	SPBC1711.05	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASSSPECTROMETRY.
PubMed: 18257517