SAK1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SAK1_SCHPO
• UniProt AC: P48383
• Protein Name: Protein sak1
• Gene Name: sak1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 766
• Subcellular Localization: Nucleus .
• Protein Description: Positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle..
• Protein Sequence: MNPSDLPGQIPLSRSDMNVQDQLDPVQRFDTHFMLPQEENFLNRPSITSESAHPRGSDLEQETELKRLALEHEHYSLESLAEKLRMDHVSANSEKFRQVFGICWLKRACEEQQDAAVQRNQIYAHYVEICNSLHIKPLNSASFGKLVRLLFPSIKTRRLGMRGHSKYHYCGIKLRGQDSFRRLRTFSDSSLSPVSCSSFPKPIPNHFENDVSSIQNTNQRVESSPASVNAAAIVRKSAVTPSSDPYNSPPPSIPLLGSQTNLQLAPSFAAPQAHPLPSHLSQSNVPPQLSHSSVPSPAPPRSVSQPTYFSQPMPQFSSSFVPGTSSIVPTLHPASAQEDFNLQHSLFFKLKLKFLPPHKLPWIPSLDVSSFSLPPIDYYLNGPYDNVEAKSALMNIYSSHCITLIESVRYMHLKQFLSEISNFPNSLSPSLLALLSSPYFTKWIERSDTVMYREILKLLFPMTLQVVPPPVLVLLRHLAENLVNHISSIYASHSSCLLQVKSETAAIFSNLLSRLLRVNDTAHAAARFLANPADRHLICNDWERFVSTRFIVHRELMCNDKEAVAALDEWYSILSTCSNPSELLDPLKDKHEASDTSMNRVELRQIDGVLDRMADFFLELPSRFPSCSPRMFLLCLGALQTSVLREITVSGGEAFGALWVIRCWVDEYMTWVAEIGGYLDDSYDELEQHHANFHNKAGISQSNIPPHLQEHRQSQQHFQQDIEALQSQQQQQATKNSLMEAAYQNAQKQKEDDYISIVFDTNGACS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	TFSDSSLSPVSCSSF CCCCCCCCCCCCCCC	25.79	27738172
217	Phosphorylation	DVSSIQNTNQRVESS CHHHHHCCCCHHHCC	19.16	21712547
223	Phosphorylation	NTNQRVESSPASVNA CCCCHHHCCCCHHHH	38.47	28889911
224	Phosphorylation	TNQRVESSPASVNAA CCCHHHCCCCHHHHH	15.81	28889911
227	Phosphorylation	RVESSPASVNAAAIV HHHCCCCHHHHHHHH	21.20	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SAK1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SAK1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SAK1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUT1_SCHPO	cut1	genetic	15507118
SECU_SCHPO	cut2	genetic	15507118
SSB1_SCHPO	sks2	genetic	15507118
SAK1_SCHPO	sak1	physical	26771498
YOG8_SCHPO	SPBC15D4.08c	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-223; SER-224 ANDSER-227, AND MASS SPECTROMETRY.
PubMed: 18257517