MIP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIP1_SCHPO
• UniProt AC: P87141
• Protein Name: Target of rapamycin complex 1 subunit mip1 {ECO:0000305|PubMed:18076573}
• Gene Name: mip1 {ECO:0000303|PubMed:10648609}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1313
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2..
• Protein Sequence: MNDRISEVSGSSRARRSVLSYGTTETGSDRYTENSNIATENGVDTASSMIDGIQSGFPQPRHGFEEEYNNAEYINMLEQVFYMYYTDKRHRGVISKKNAEPTETIHDWRMRERLKTVSAALLVCLNIGVDPPDVIKPNPAAKYECWIDPFSLPASKALEAIGKNLQQQYETLSMRTRYRHYLDPAIEEVKKLCIGQRRNAKEERILFHYNGHGVPMPTASGEIWVFNKNYTQYIPVSLYDLQSWLGAPCIYVYDCSAAGNIIVNFNRFAEQRDKEALRIAKQNPNVLAMPSHTSCIQLAACGPKETLPMNPDLPADLFTSCLTSPIEISVRWYVLQNPFPNKLNLNMLLKIPGRLQDRRTPLGELNWIFTAITDTIAWNVFPKHLFRRLFRQDLMVAALFRNFLLAERIMLVHSCHPQSSPELPPTHDHPMWNSWDLAIDNCLSQLPDMLDAESKGIAYEYKHSTFFSEQLTAFEVWLSQGLISRKPPDQLPLVLQVLLSQVHRLRALILLSKFLDLGVWAVDLALSIGIFPYVLKLLQSPAIELKPVLVFIWARILAVDDSCQADLLKDNGYGYFVQILNPNSSIFPSSNISEHRAMCAFILSVFCRGFPQGQLACLNPQVLSHCLSHLNSPDSLLRQWACLCISQLWENYSEAKWSGTRDNAHVKLAEIIVDSVPEVRASVLTAFTTFLGFPEKTEEVVAVETYIAIAALAALSDASPLVRHELVIFLSHFVVNYKKQLMVVAYESSLADILEKKNHNSISASTIYETVWQAVLVLAADPSIEISLAAEAIINYVYQSMLNSELRESFLAFLLQHLPALHKASLSKDTDTNSVTSDPKPHPFVPSVSENKILNRSFSLTRSLKGLALSLAGSDRASELLSLNGENKPAESNLNHLTSAKVPGPPAFNELEYQSELDMPLTSYLFDWSRKYFTEPQMRPNEDDEPGSICYNQRLWRRNRNEKLIYRTRPLAEYSTNGRWNQQLMTFNNTIAPRKLMFHQFEDQLITLGDKDIIQVWDWRRNRCLNSFKTSASATTNVTDMQLLNEDDVALLMTGSSDGTIKLYRDYENEKVELVTSWNSLSDLVFGDRNASLLMSWQQNCGHLLVAGDVRVIRIWDASKEICYANLPVRSSNSITSLTSDLVGCNIIVAGFSDGVLRVYDKRLPARDSLTDVWKEHSSEIVNVEMQSSGMRELISASSDGEVKLWDIRMNHSLQTFSTDNSGLTSLTVHSHAPVYATGSSNQSIKIWDTLGQNINTFRENPRFLNQPKPSSLMCLKFHPHHLLLACGDNTDSRVNLYSCTKNEIHTDSPNEF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	RISEVSGSSRARRSV HHHHCCCCHHHHHHH	14.78	27738172
830	Phosphorylation	KASLSKDTDTNSVTS HHHCCCCCCCCCCCC	48.75	25720772
832	Phosphorylation	SLSKDTDTNSVTSDP HCCCCCCCCCCCCCC	31.33	24763107
834	Phosphorylation	SKDTDTNSVTSDPKP CCCCCCCCCCCCCCC	28.94	28889911
836	Phosphorylation	DTDTNSVTSDPKPHP CCCCCCCCCCCCCCC	27.51	21712547
837	Phosphorylation	TDTNSVTSDPKPHPF CCCCCCCCCCCCCCC	50.16	28889911
847	Phosphorylation	KPHPFVPSVSENKIL CCCCCCCCCCCCCCC	32.73	21712547
849	Phosphorylation	HPFVPSVSENKILNR CCCCCCCCCCCCCCC	39.53	21712547
857	Phosphorylation	ENKILNRSFSLTRSL CCCCCCCHHHHHHHH	20.36	21712547
859	Phosphorylation	KILNRSFSLTRSLKG CCCCCHHHHHHHHHH	30.03	21712547
861	Phosphorylation	LNRSFSLTRSLKGLA CCCHHHHHHHHHHHH	19.60	21712547
863	Phosphorylation	RSFSLTRSLKGLALS CHHHHHHHHHHHHHH	29.24	21712547
870	Phosphorylation	SLKGLALSLAGSDRA HHHHHHHHHHCCHHH	15.57	25720772
874	Phosphorylation	LALSLAGSDRASELL HHHHHHCCHHHHHHH	20.51	28889911
878	Phosphorylation	LAGSDRASELLSLNG HHCCHHHHHHHCCCC	29.66	29996109
882	Phosphorylation	DRASELLSLNGENKP HHHHHHHCCCCCCCC	32.20	18076573
1309	Phosphorylation	KNEIHTDSPNEF--- CCEECCCCCCCC---	30.68	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEI2_SCHPO	mei2	physical	10648609
STE11_SCHPO	ste11	physical	10648609
TOR2_SCHPO	tor2	physical	17046992
TOR2_SCHPO	tor2	physical	22762302

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-837, AND MASSSPECTROMETRY.
PubMed: 18257517