WAT1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WAT1_SCHPO
• UniProt AC: O74184
• Protein Name: Target of rapamycin complex subunit wat1 {ECO:0000305|PubMed:18076573}
• Gene Name: pop3 {ECO:0000303|PubMed:11686295}
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 314
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: component of both TORC1 and TORC2, which regulate multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11 and the meiosis-promoting RNA-binding protein mei2. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. [PubMed: 17046992]
• Protein Sequence: MSVQYPPQHSVLLVSSGYDHTIRFWEALSGICSRTIQHADSQVNRLCISPDKKFLAAAGNPHVRLYDINTSSQMPLMTFEGHTNNVTAIAFHCDGKWLATSSEDGTVKVWDMRAPSVQRNYDHKSPVNDLLIHPNQGELLSCDQSGRVRAWDLGENSCTHELIPEEDVPMSSITVGSDGSMLIAGNNKGNCYVWRMLNHQGASLLQPVVKFQAHQRYITRCVLSPDVKHLATCSADATVNIWSTEDMSFMLERRLQGHQRWVWDCAFSADSTYLVTASSDHVARLWELSSGETIRQYSGHHKAAVCVALNDYQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
141	Phosphorylation	PNQGELLSCDQSGRV CCCCCCEEECCCCCE	28.42	18076573

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WAT1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WAT1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WAT1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUT1_SCHPO	cut1	genetic	15507118
U2AF2_SCHPO	prp2	physical	11686295
TOR2_SCHPO	tor2	physical	17046992
TOR1_SCHPO	tor1	physical	17046992
YN25_SCHPO	prt1	physical	26771498
YQ65_SCHPO	SPCC191.05c	physical	26771498
TOR1_SCHPO	tor1	physical	28264193

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.