| UniProt ID | U2AF2_SCHPO | |
|---|---|---|
| UniProt AC | P36629 | |
| Protein Name | Splicing factor U2AF 59 kDa subunit | |
| Gene Name | prp2 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 517 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.. | |
| Protein Sequence | MDLSSRLSSGSSRIPKRHRDYRDEEPRRERGSGGIGREDPRGHYGSERPRRRRRDESDFRRHRESRERSYREDERPRRERRYDDYEPRSLRYSSVGRSRSPPPSRERSVRSIEQELEQLRDVTPINQWKRKRSLWDIKPPGYELVTADQAKMSGVFPLPGAPRAAVTDPEKLLEFARSAEGSIIAPPPPLQPGASRQARRLVVTGIPNEFVEDAFVSFIEDLFISTTYHKPETKHFSSVNVCKEENFAILEVATPEDATFLWGLQSESYSNDVFLKFQRIQNYIVPQITPEVSQKRSDDYAKNDVLDSKDKIYISNLPLNLGEDQVVELLKPFGDLLSFQLIKNIADGSSKGFCFCEFKNPSDAEVAISGLDGKDTYGNKLHAQFACVGLNQAMIDKSNGMAILTELAKASSQSIPTRVLQLHNLITGDEIMDVQEYEDIYESVKTQFSNYGPLIDIKIPRSIGTRNSGLGTGKVFVRYSDIRSAEVAMEEMKGCKFNDRTIVIAFYGEDCYKANAW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 8 | Phosphorylation | MDLSSRLSSGSSRIP CCHHHHCCCCCCCCC | 31.38 | 21712547 | |
| 9 | Phosphorylation | DLSSRLSSGSSRIPK CHHHHCCCCCCCCCH | 47.49 | 24763107 | |
| 93 | Phosphorylation | EPRSLRYSSVGRSRS CCCCCCCCCCCCCCC | 16.47 | 25720772 | |
| 94 | Phosphorylation | PRSLRYSSVGRSRSP CCCCCCCCCCCCCCC | 21.47 | 25720772 | |
| 98 | Phosphorylation | RYSSVGRSRSPPPSR CCCCCCCCCCCCCCC | 31.05 | 25720772 | |
| 100 | Phosphorylation | SSVGRSRSPPPSRER CCCCCCCCCCCCCHH | 42.90 | 25720772 | |
| 111 | Phosphorylation | SRERSVRSIEQELEQ CCHHHHHHHHHHHHH | 28.46 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of U2AF2_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of U2AF2_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of U2AF2_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DSK1_SCHPO | dsk1 | genetic | 10629038 | |
| SF3B1_SCHPO | prp10 | genetic | 9837997 | |
| WAT1_SCHPO | pop3 | physical | 11686295 | |
| U2AF1_SCHPO | uaf2 | physical | 15548596 | |
| YOI5_SCHPO | SPBC1778.05c | genetic | 22681890 | |
| RICTR_SCHPO | ste20 | genetic | 22681890 | |
| YIDH_SCHPO | SPAC227.17c | genetic | 22681890 | |
| SRP2_SCHPO | srp2 | genetic | 26302002 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
