| UniProt ID | SF3B1_SCHPO | |
|---|---|---|
| UniProt AC | Q10178 | |
| Protein Name | U2 snRNP component prp10 | |
| Gene Name | prp10 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 1205 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly.. | |
| Protein Sequence | MSTGTYPYKMFKMDVTNLNKVEDVEIERLRAERELLRRQKEAAKNSSTNGSVNIEGTQDSNDLQYNAHLFKSSNPKEEYDSAIDVRNDISQDEDDYKRTNDVNDSYRLVRQYEAPKELLNEYADESYDPMQERQSKKQIQDRESDYQKQRYDRQLTPTRVDAFQPDGTQSNGRSYAEVMRQVELEKEERRVHMELNQRRREGTLKEVEEEESISDKKRELELNNTEISQKPKRSRWDQAPPSVTQVSTTKRRSRWDKAPENFTISEHVIENGISEDLINKEVNVVEEKLRPPVRLLTEEELNELLPSEGYAILEPPPGYLESIHPELLQKGTTLDTYHVPQEQELPLEKELPAALPTEIPGVGDLAFFKQEDVKYFGKLLKVEDEAKLTIAELRERKILRLLLKVKNGTPPMRKSALRQLTDQARDFGAAALFNQILPLLMERTLEDQERHLLVKVIDRILYKLDDLVRPFTHKILVVIEPLLIDEDYYARAEGREIISNLAKASGLAHMIATMRPDIDHVDEYVRNTTARAFSVVASALGVPALLPFLKAVCRSKKSWQARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLEDEQQKVRIMTALSLSALAEAATPYGIEAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPYLPQIVSTILYRLNNKSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYPEVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPILRNRHEKVQENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTPEMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESPHVINAVREGIDGIRNCIGVGPIMAYLVQGLFHPSRKVRNTYWTSYNSAYVQSADAMVPYYPHVDDDQFNNYDMKTLHICI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 73 | Phosphorylation | NAHLFKSSNPKEEYD EEEECCCCCCHHHHC | 58.71 | 28889911 | |
| 90 | Phosphorylation | IDVRNDISQDEDDYK CCCCCCCCCCCCHHH | 34.15 | 28889911 | |
| 156 | Phosphorylation | QRYDRQLTPTRVDAF HHHHHCCCCCCCCCC | 17.80 | 28889911 | |
| 158 | Phosphorylation | YDRQLTPTRVDAFQP HHHCCCCCCCCCCCC | 37.78 | 29996109 | |
| 948 | Phosphorylation | GKIADRGSEYVSARE HHHCCCCCCCCCHHH | 27.01 | 25720772 | |
| 950 | Phosphorylation | IADRGSEYVSAREWM HCCCCCCCCCHHHHH | 11.03 | 25720772 | |
| 952 | Phosphorylation | DRGSEYVSAREWMRI CCCCCCCCHHHHHHH | 22.25 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SF3B1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SF3B1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SF3B1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| U2AF2_SCHPO | prp2 | physical | 10923022 | |
| U2AF2_SCHPO | prp2 | physical | 14730023 | |
| RSE1_SCHPO | prp12 | genetic | 11350031 | |
| NUP85_SCHPO | nup85 | genetic | 22240020 | |
| REXO3_SCHPO | rex3 | genetic | 22681890 | |
| SPP1_SCHPO | spf1 | genetic | 22681890 | |
| THP3_SCHPO | iss9 | genetic | 22681890 | |
| CYB51_SCHPO | SPBC29A10.16c | genetic | 22681890 | |
| SPF31_SCHPO | spf31 | genetic | 22681890 | |
| YJC7_SCHPO | SPCC736.07c | genetic | 22681890 | |
| UAP2_SCHPO | uap2 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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