| UniProt ID | DSK1_SCHPO | |
|---|---|---|
| UniProt AC | P36616 | |
| Protein Name | Protein kinase dsk1 | |
| Gene Name | dsk1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 544 | |
| Subcellular Localization | Cytoplasm . Nucleus . Enriched in the nucleus in mitotically arrested mutant and wild-type mitotic cells but cytoplasmic enriched in cells at other cell-cycle stages. | |
| Protein Description | May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle.. | |
| Protein Sequence | MGSDGSSLSPKVSQPGHTEIVDHVSEKVITNGKNVNKKVNAEVDGKSMVEKVKTHEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLAYDRAAKRRVALKVVRSAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVCMVFEVLGENLLSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDALQHIEAPATTSSPTSNTSSSKTRNNTGYTAKAPIIKRGQSVDNSAQERKTFAKNPTKNSKPAGQVIPSSPFTSTLSRFPSLEGAVSEISLRDSQKHNSHPNSPFSSGDNSLILDGVNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSFACIIFELLTGDYLFDPRNGNSYSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIHKLKFWPLKDVLEQKYHFSAELAQQISDFLSPMLCFDPAKRTNAGYMSNSPWLREVADPTFKIETTGATGEDVPGWATEIR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MGSDGSSLSPKVSQ -CCCCCCCCCCCCCC | 38.09 | 21712547 | |
| 9 | Phosphorylation | GSDGSSLSPKVSQPG CCCCCCCCCCCCCCC | 25.31 | 21712547 | |
| 25 | Phosphorylation | TEIVDHVSEKVITNG CEEHHHCCHHEECCC | 28.42 | 21712547 | |
| 47 | Phosphorylation | NAEVDGKSMVEKVKT CEEECCHHHHHHHHC | 33.32 | 25720772 | |
| 268 | Phosphorylation | PIIKRGQSVDNSAQE CEEECCCCCCCHHHH | 33.97 | 24763107 | |
| 272 | Phosphorylation | RGQSVDNSAQERKTF CCCCCCCHHHHHHHH | 27.19 | 21712547 | |
| 296 | Phosphorylation | PAGQVIPSSPFTSTL CCCCCCCCCCCCCHH | 39.25 | 21712547 | |
| 297 | Phosphorylation | AGQVIPSSPFTSTLS CCCCCCCCCCCCHHH | 20.76 | 29996109 | |
| 308 | Phosphorylation | STLSRFPSLEGAVSE CHHHCCCCCCCCEEE | 36.02 | 25720772 | |
| 314 | Phosphorylation | PSLEGAVSEISLRDS CCCCCCEEEEECCCH | 28.78 | 25720772 | |
| 317 | Phosphorylation | EGAVSEISLRDSQKH CCCEEEEECCCHHHC | 17.19 | 25720772 | |
| 321 | Phosphorylation | SEISLRDSQKHNSHP EEEECCCHHHCCCCC | 34.39 | 25720772 | |
| 326 | Phosphorylation | RDSQKHNSHPNSPFS CCHHHCCCCCCCCCC | 39.79 | 28889911 | |
| 330 | Phosphorylation | KHNSHPNSPFSSGDN HCCCCCCCCCCCCCC | 31.60 | 28889911 | |
| 333 | Phosphorylation | SHPNSPFSSGDNSLI CCCCCCCCCCCCCEE | 36.47 | 21712547 | |
| 334 | Phosphorylation | HPNSPFSSGDNSLIL CCCCCCCCCCCCEEE | 51.01 | 21712547 | |
| 338 | Phosphorylation | PFSSGDNSLILDGVN CCCCCCCCEEEECCC | 22.87 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DSK1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DSK1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DSK1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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