KCC1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCC1_SCHPO
• UniProt AC: Q9P7I2
• Protein Name: Calcium/calmodulin-dependent protein kinase type I
• Gene Name: cmk1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 335
• Subcellular Localization: Cytoplasm .
• Protein Description: Important in cell cycle regulation..
• Protein Sequence: MQQTYKPNTSALKDGAPKATVDQKQLLPCKYRVGRVLGGGTYATVREAVHIETNKMYAAKIMNKKMMEKKQDFVKNEIAILKRVSYEHPNILHLVDFFETVNNLYLITELATGGELFDRICAKGSFYEADAAALMRTTTSAVKYLHDNGIVHRDLKPENLLYRSKDPNSDLLIADFGLSHFYEDSQYYMLMTACGTPEYMAPEVFRRTGYGKPVDMWAIGVITYFLLSGYTPFARPSQVEVIEAILANEYTFNDPCWSGISETAKDFIKKCLENDPSKRLTAADALKHPFLSEKRPATSNLLPNVRENFNARKTFRTAYNAVRAFNTWKKLENKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	SQYYMLMTACGTPEY CCCHHHHHCCCCCHH	18.16	10617667

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
192	T	Phosphorylation	Kinase	CMK1	Q9P7I2	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCC1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCC1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRZ1_SCHPO	prz1	physical	25081204
PRZ1_SCHPO	prz1	genetic	25081204
PP2B_SCHPO	ppb1	genetic	25081204
MPIP_SCHPO	cdc25	genetic	25081204

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Cloning of a calmodulin kinase I homologue from Schizosaccharomycespombe.";
Rasmussen C.D.;
J. Biol. Chem. 275:685-690(2000).
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, PHOSPHORYLATION ATTHR-192, AND MUTAGENESIS OF THR-192.
PubMed: 10617667