YFHH_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YFHH_SCHPO
• UniProt AC: O42854
• Protein Name: SH3 domain-containing protein C23A1.17
• Gene Name: SPAC23A1.17
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1611
• Subcellular Localization: Cytoplasm . Localizes at the cell tip and barrier septum.
• Protein Sequence: MSSFPTRVVALYPYRSSFSDDLEFDPGQVIDVVSNLDGDWYTGTYVDSDGNRKIGSFPKDFTEPAEDAVFVERASEMALHQPTPTSAVHSRNSSLGYAPSITRSIKSISNNTEHLGADTESYLSANDFIDSTSEALTKIVDVDTLSAPFGNDSNSRPHSLKNVEKLHTFSAPYTISEETPSCSTENDSLPLTATHTITGGEDAATGAAVTNTTTTHITTSTNTSTVIPSNPNSVFLVDCTHSQCPTDLPNIATTQHSLRYLDNASASAITVLERTHPAASSTMATESSHQSPSADSQAEELSKSQRVAKDDDPFVVSNTANSDEPASSSKPAKPLTDLNRAFSQRLNLDPQKPGKSQGEISEQEEDEYDDAESDEMHSPYSTHEPESEPEDQDEPSEKDDENKDVEEEQEQEQEEEQIDPEEAKRIALRERMAKMSGGIGMHVFGLPGLAAPIGRKNTLRRTPAKSSEEAKSTTNDSSPPKDSSSTSTQPTEQSNAQQAPSPKEEERPLPSEPSQNQPAEYRDTPDTPRNIMPLPGLMSADQPIKVTEPSNDADKAIVAEGPNNEEETKGPVIPETQETSEQQVHKTPSPEKQKVLSPPPIITNFDKETLASNEAHEAVPQKPSAPQVTRLMAPQDSSSVVTPSPTSLLDPARAVRKVIDGIDPPKEAGAGATADVESAANSPITPPRTWHSPDFTSKSFEPIERKLPSRISEVTEDSIDEDKQNEVDPSTSARALPPPGLRFGKVDTLASLAHDDLDDLPAVPRIFSPPPLPKTPSGEFGDNEFMFPKKSNRVRGHQSRPSTGSQLRNVVPVSIVTSGGRPALPDEMASPSSSIGHPLPSPPPADFNSLNVDFYEPHSYLESPAPEPQPSYEEESFNATVIHAPTPSTATFQGHPTISNVATPPLKQDVTESKASPVADASATHQSSTGLTQEITQLGSNMRLPTKLTRPSNDGRKASGPRPAAPPSIPPPLPVSNILSSPTSEPPKDHPPSAPLSKPVSTSPAAPLARVPPVPKLSSKAPPVPLPSADAPPIPVPSTAPPVPIPTSTPPVPKSSSGAPSAPPPVPAPSSEIPSIPAPSGAPPVPAPSGIPPVPKPSVAAPPVPKPSVAVPPVPAPSGAPPVPKPSVAAPPVPVPSGAPPVPKPSVAAPPVPAPSGAPPVPKPSVAAPPVPAPSSGIPPVPKPAAGVPPVPPPSEAPPVPKPSVGVPPVPPPSTAPPVPTPSAGLPPVPVPTAKAPPVPAPSSEAPSVSTPRSSVPSPHSNASPSPTSSSMASAAPARTSVSRSKSKAERHETSTSSRKSSKSGEHHHHHNEGHADSSSTRTSLAHQDSRKSLHRHLSRSSSRASKKPSIVSTTGPFNESFSAKPVEPCASEKWWLNSTAVPKSVVQMNDSVLYMIKEGITGQDKKYKSVHILFPDYSQTVLTATFNPHNQNITQLSQLQLAPPAQPSKARLDEEYACYGSTILKKARAYQGSMVGDGSAFTFVNSVMSILAHNLEPINKQTFGGVIYKNVGNVTVQQIGEIRPGDIVTFDKAKFSGQKGTLRSKYSLEVGKPMHYGIISEWDVSKLKIRVLEQGRESKKVSVASYKFGDLKSGEVTVWRVMRRSWLGWN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Phosphorylation	GSFPKDFTEPAEDAV CCCCCCCCCCHHHCC	51.71	28889911
85	Phosphorylation	ALHQPTPTSAVHSRN HHCCCCCCHHHCCCC	31.62	28889911
86	Phosphorylation	LHQPTPTSAVHSRNS HCCCCCCHHHCCCCC	29.51	25720772
90	Phosphorylation	TPTSAVHSRNSSLGY CCCHHHCCCCCCCCC	26.93	25720772
93	Phosphorylation	SAVHSRNSSLGYAPS HHHCCCCCCCCCCCH	26.32	25720772
94	Phosphorylation	AVHSRNSSLGYAPSI HHCCCCCCCCCCCHH	29.39	28889911
97	Phosphorylation	SRNSSLGYAPSITRS CCCCCCCCCCHHHHH	22.19	25720772
100	Phosphorylation	SSLGYAPSITRSIKS CCCCCCCHHHHHHHH	28.55	25720772
102	Phosphorylation	LGYAPSITRSIKSIS CCCCCHHHHHHHHHC	23.77	25720772
109	Phosphorylation	TRSIKSISNNTEHLG HHHHHHHCCCCCCCC	30.99	21712547
144	Phosphorylation	TKIVDVDTLSAPFGN HHCCCCCCCCCCCCC	23.59	21712547
146	Phosphorylation	IVDVDTLSAPFGNDS CCCCCCCCCCCCCCC	35.67	24763107
153	Phosphorylation	SAPFGNDSNSRPHSL CCCCCCCCCCCCCCC	40.48	25720772
155	Phosphorylation	PFGNDSNSRPHSLKN CCCCCCCCCCCCCCC	51.66	25720772
159	Phosphorylation	DSNSRPHSLKNVEKL CCCCCCCCCCCHHHE	43.66	21712547
265	Phosphorylation	LRYLDNASASAITVL HHHHHCCCCCCEEEE	29.07	25720772
267	Phosphorylation	YLDNASASAITVLER HHHCCCCCCEEEECC	20.08	25720772
270	Phosphorylation	NASASAITVLERTHP CCCCCCEEEECCCCC	20.82	25720772
319	Phosphorylation	DPFVVSNTANSDEPA CCCEEECCCCCCCCC	21.51	29996109
322	Phosphorylation	VVSNTANSDEPASSS EEECCCCCCCCCCCC	40.67	21712547
336	Phosphorylation	SKPAKPLTDLNRAFS CCCCCCCHHHHHHHH	47.14	21712547
343	Phosphorylation	TDLNRAFSQRLNLDP HHHHHHHHHHCCCCC	17.26	24763107
458	Phosphorylation	APIGRKNTLRRTPAK CCCCCCCCCCCCCCC	25.36	24763107
477	Phosphorylation	AKSTTNDSSPPKDSS HHHCCCCCCCCCCCC	46.98	25720772
478	Phosphorylation	KSTTNDSSPPKDSSS HHCCCCCCCCCCCCC	48.35	25720772
483	Phosphorylation	DSSPPKDSSSTSTQP CCCCCCCCCCCCCCC	32.11	25720772
484	Phosphorylation	SSPPKDSSSTSTQPT CCCCCCCCCCCCCCC	48.01	25720772
501	Phosphorylation	SNAQQAPSPKEEERP CCCCCCCCCCCCCCC	52.17	28889911
521	Phosphorylation	SQNQPAEYRDTPDTP CCCCCCCCCCCCCCC	18.85	29996109
524	Phosphorylation	QPAEYRDTPDTPRNI CCCCCCCCCCCCCCC	17.67	29996109
576	Phosphorylation	KGPVIPETQETSEQQ CCCCCCCCHHCCHHH	26.76	21712547
579	Phosphorylation	VIPETQETSEQQVHK CCCCCHHCCHHHCCC	27.96	21712547
580	Phosphorylation	IPETQETSEQQVHKT CCCCHHCCHHHCCCC	32.43	21712547
587	Phosphorylation	SEQQVHKTPSPEKQK CHHHCCCCCCHHHHH	17.70	24763107
589	Phosphorylation	QQVHKTPSPEKQKVL HHCCCCCCHHHHHCC	51.42	21712547
597	Phosphorylation	PEKQKVLSPPPIITN HHHHHCCCCCCEECC	38.05	28889911
642	Phosphorylation	QDSSSVVTPSPTSLL CCCCCCCCCCCHHHC	18.85	29996109
644	Phosphorylation	SSSVVTPSPTSLLDP CCCCCCCCCHHHCCH	31.29	29996109
646	Phosphorylation	SVVTPSPTSLLDPAR CCCCCCCHHHCCHHH	36.02	29996109
647	Phosphorylation	VVTPSPTSLLDPARA CCCCCCHHHCCHHHH	30.25	29996109
673	Phosphorylation	KEAGAGATADVESAA HHCCCCCCCCHHHHH	23.60	24763107
678	Phosphorylation	GATADVESAANSPIT CCCCCHHHHHCCCCC	32.31	21712547
682	Phosphorylation	DVESAANSPITPPRT CHHHHHCCCCCCCCC	16.98	24763107
685	Phosphorylation	SAANSPITPPRTWHS HHHCCCCCCCCCCCC	30.53	24763107
692	Phosphorylation	TPPRTWHSPDFTSKS CCCCCCCCCCCCCCC	20.09	28889911
699	Phosphorylation	SPDFTSKSFEPIERK CCCCCCCCCHHHHHH	34.31	24763107
709	Phosphorylation	PIERKLPSRISEVTE HHHHHCCHHHHHCCC	53.32	21712547
712	Phosphorylation	RKLPSRISEVTEDSI HHCCHHHHHCCCCCC	25.55	24763107
715	Phosphorylation	PSRISEVTEDSIDED CHHHHHCCCCCCCHH	29.98	24763107
718	Phosphorylation	ISEVTEDSIDEDKQN HHHCCCCCCCHHHHC	26.21	24763107
748	Phosphorylation	LRFGKVDTLASLAHD CCCCCHHHHHHHCCC	27.49	21712547
751	Phosphorylation	GKVDTLASLAHDDLD CCHHHHHHHCCCCHH	29.24	29996109
768	Phosphorylation	PAVPRIFSPPPLPKT CCCCCCCCCCCCCCC	33.84	28889911
775	Phosphorylation	SPPPLPKTPSGEFGD CCCCCCCCCCCCCCC	22.28	24763107
777	Phosphorylation	PPLPKTPSGEFGDNE CCCCCCCCCCCCCCC	57.07	28889911
799	Phosphorylation	NRVRGHQSRPSTGSQ CCCCCCCCCCCCCCC	40.25	28889911
802	Phosphorylation	RGHQSRPSTGSQLRN CCCCCCCCCCCCCCC	44.27	29996109
803	Phosphorylation	GHQSRPSTGSQLRNV CCCCCCCCCCCCCCE	43.46	25720772
805	Phosphorylation	QSRPSTGSQLRNVVP CCCCCCCCCCCCEEE	26.57	29996109
911	Phosphorylation	PPLKQDVTESKASPV CCCCCCCCCCCCCCC	42.71	21712547
916	Phosphorylation	DVTESKASPVADASA CCCCCCCCCCCCHHH	24.52	24763107
922	Phosphorylation	ASPVADASATHQSST CCCCCCHHHCCCCCC	33.96	29996109
924	Phosphorylation	PVADASATHQSSTGL CCCCHHHCCCCCCCC	20.25	21712547
927	Phosphorylation	DASATHQSSTGLTQE CHHHCCCCCCCCHHH	23.43	21712547
959	Phosphorylation	SNDGRKASGPRPAAP CCCCCCCCCCCCCCC	52.98	24763107
968	Phosphorylation	PRPAAPPSIPPPLPV CCCCCCCCCCCCCCH	46.82	29996109
976	Phosphorylation	IPPPLPVSNILSSPT CCCCCCHHHCCCCCC	19.06	21712547
980	Phosphorylation	LPVSNILSSPTSEPP CCHHHCCCCCCCCCC	30.40	21712547
981	Phosphorylation	PVSNILSSPTSEPPK CHHHCCCCCCCCCCC	28.84	21712547
997	Phosphorylation	HPPSAPLSKPVSTSP CCCCCCCCCCCCCCC	33.58	21712547
1001	Phosphorylation	APLSKPVSTSPAAPL CCCCCCCCCCCCCCH	31.52	21712547
1002	Phosphorylation	PLSKPVSTSPAAPLA CCCCCCCCCCCCCHH	38.68	24763107
1003	Phosphorylation	LSKPVSTSPAAPLAR CCCCCCCCCCCCHHC	12.68	21712547
1047	Phosphorylation	APPVPIPTSTPPVPK CCCCCCCCCCCCCCC	46.05	29996109
1048	Phosphorylation	PPVPIPTSTPPVPKS CCCCCCCCCCCCCCC	33.30	29996109
1049	Phosphorylation	PVPIPTSTPPVPKSS CCCCCCCCCCCCCCC	33.81	29996109
1243	Phosphorylation	APPVPAPSSEAPSVS CCCCCCCCCCCCCCC	42.80	28889911
1244	Phosphorylation	PPVPAPSSEAPSVST CCCCCCCCCCCCCCC	36.40	28889911
1248	Phosphorylation	APSSEAPSVSTPRSS CCCCCCCCCCCCCCC	35.43	25720772
1251	Phosphorylation	SEAPSVSTPRSSVPS CCCCCCCCCCCCCCC	22.14	28889911
1254	Phosphorylation	PSVSTPRSSVPSPHS CCCCCCCCCCCCCCC	36.57	25720772
1255	Phosphorylation	SVSTPRSSVPSPHSN CCCCCCCCCCCCCCC	39.05	28889911
1258	Phosphorylation	TPRSSVPSPHSNASP CCCCCCCCCCCCCCC	32.84	28889911
1261	Phosphorylation	SSVPSPHSNASPSPT CCCCCCCCCCCCCCC	37.16	28889911
1264	Phosphorylation	PSPHSNASPSPTSSS CCCCCCCCCCCCCHH	30.11	29996109
1266	Phosphorylation	PHSNASPSPTSSSMA CCCCCCCCCCCHHHH	38.01	28889911
1268	Phosphorylation	SNASPSPTSSSMASA CCCCCCCCCHHHHHH	45.65	25720772
1269	Phosphorylation	NASPSPTSSSMASAA CCCCCCCCHHHHHHC	24.65	25720772
1270	Phosphorylation	ASPSPTSSSMASAAP CCCCCCCHHHHHHCC	26.98	25720772
1274	Phosphorylation	PTSSSMASAAPARTS CCCHHHHHHCCCCCC	19.13	25720772
1281	Phosphorylation	SAAPARTSVSRSKSK HHCCCCCCCCCCHHH	16.73	27738172
1324	Phosphorylation	DSSSTRTSLAHQDSR CCCCCHHHHHCHHHH	21.92	29996109
1330	Phosphorylation	TSLAHQDSRKSLHRH HHHHCHHHHHHHHHH	34.73	29996109
1333	Phosphorylation	AHQDSRKSLHRHLSR HCHHHHHHHHHHHHH	28.44	25720772
1379	Phosphorylation	SEKWWLNSTAVPKSV CCCCCCCCCCCCHHH	18.64	28889911
1380	Phosphorylation	EKWWLNSTAVPKSVV CCCCCCCCCCCHHHE	30.51	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YFHH_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YFHH_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YFHH_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELP3_SCHPO	elp3	genetic	19547744

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1258; SER-1261;SER-1266; SER-1379 AND THR-1380, AND MASS SPECTROMETRY.
PubMed: 18257517