KJ45_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KJ45_SCHPO
• UniProt AC: O74526
• Protein Name: Probable serine/threonine-protein kinase C70.05c
• Gene Name: SPCC70.05c
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 781
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MPSDKPVFDIGSQAPERSDSESPSSRSIGSGTPAPVRKGLSKFKNSFLSRKNSSQIKSPSDYKSSAHEQRVNHTTDSMAHVPGNNSPLQTPQKSPPRQKHTAPATPIPVSASRHHKPHHSGLKNLLEKAMHPGHKSNANSPTSESPSKGFGSFINNHILHKNTSSHPSSPVNGKSSDIHKSQSYQHLKNSPPNSRTARKPVPRRANSASHNLGSTKSPNGNAKESLSRSAELPSKAKPMEINNGYRKKPSPLSPNSSIRNREGGNGSYFDGPLTASPTPSSPTGTPNSMSKSPSLSSLASTGASYRPGPSKPLVSRVRDNYANTSYESWPHSTEFDMFTYAVSGSLKLTPQGTGFDCINPANPFSPGYSGKSSMKSDDNVGSSANTAPNSPTSANSSEGNQGNGPTTYPIKPPTNISEIPRKLKSGFIPPYAKRVVPRLSAKYKLVDETKDMGSGATAVIRIVTLKNPKENEKNLRFAVKAYRRKADDETDGQYIAKLASEWLVQCRMEHPNVVKSYDLCIDSHIFPLYSDTWCAVMDFCPRGDLLSLIEDRHDRLGKKDFECMIKQILRGLNYIHSQGIAHRDIKPENILISEYGVLRITDFGACDVLCNPGDDITAVESKSMGIFGSDPYMAPEILTPGSYNAFFADMWSTAIVLHCLYFRTYPFRKASQNDQLYAKYCKAWREYNLICDVQNIRISKTLPYFKPVNDLPMHMQRLFFCLANPTAEQRITAQEALNLPFVQEIECCSVDDCTCTHDAPEECLEWANPPVQKLSTPHNHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSDKPVFDI -----CCCCCCCCCC	57.90	21712547
12	Phosphorylation	KPVFDIGSQAPERSD CCCCCCCCCCCCCCC	24.41	29996109
18	Phosphorylation	GSQAPERSDSESPSS CCCCCCCCCCCCCCC	43.77	25720772
20	Phosphorylation	QAPERSDSESPSSRS CCCCCCCCCCCCCCC	41.02	21712547
22	Phosphorylation	PERSDSESPSSRSIG CCCCCCCCCCCCCCC	33.75	24763107
24	Phosphorylation	RSDSESPSSRSIGSG CCCCCCCCCCCCCCC	47.89	21712547
25	Phosphorylation	SDSESPSSRSIGSGT CCCCCCCCCCCCCCC	33.17	24763107
27	Phosphorylation	SESPSSRSIGSGTPA CCCCCCCCCCCCCCC	33.00	29996109
30	Phosphorylation	PSSRSIGSGTPAPVR CCCCCCCCCCCCCHH	37.51	29996109
32	Phosphorylation	SRSIGSGTPAPVRKG CCCCCCCCCCCHHHH	20.27	25720772
41	Phosphorylation	APVRKGLSKFKNSFL CCHHHHHHHHHHHHH	44.72	28889911
46	Phosphorylation	GLSKFKNSFLSRKNS HHHHHHHHHHHCCCH	28.31	21712547
49	Phosphorylation	KFKNSFLSRKNSSQI HHHHHHHHCCCHHCC	38.92	21712547
53	Phosphorylation	SFLSRKNSSQIKSPS HHHHCCCHHCCCCHH	27.01	24763107
54	Phosphorylation	FLSRKNSSQIKSPSD HHHCCCHHCCCCHHH	45.37	24763107
58	Phosphorylation	KNSSQIKSPSDYKSS CCHHCCCCHHHHCCC	31.12	29996109
75	Phosphorylation	EQRVNHTTDSMAHVP HHHCCCCCCCCCCCC	20.65	29996109
77	Phosphorylation	RVNHTTDSMAHVPGN HCCCCCCCCCCCCCC	18.77	21712547
86	Phosphorylation	AHVPGNNSPLQTPQK CCCCCCCCCCCCCCC	30.87	21712547
90	Phosphorylation	GNNSPLQTPQKSPPR CCCCCCCCCCCCCCC	35.06	28889911
94	Phosphorylation	PLQTPQKSPPRQKHT CCCCCCCCCCCCCCC	34.58	28889911
101	Phosphorylation	SPPRQKHTAPATPIP CCCCCCCCCCCCCCC	41.18	21712547
105	Phosphorylation	QKHTAPATPIPVSAS CCCCCCCCCCCCCCC	22.23	21712547
110	Phosphorylation	PATPIPVSASRHHKP CCCCCCCCCCCCCCC	18.38	21712547
112	Phosphorylation	TPIPVSASRHHKPHH CCCCCCCCCCCCCCC	25.33	21712547
136	Phosphorylation	AMHPGHKSNANSPTS HCCCCCCCCCCCCCC	35.18	29996109
140	Phosphorylation	GHKSNANSPTSESPS CCCCCCCCCCCCCCC	27.43	29996109
143	Phosphorylation	SNANSPTSESPSKGF CCCCCCCCCCCCCCC	39.19	29996109
145	Phosphorylation	ANSPTSESPSKGFGS CCCCCCCCCCCCCHH	33.95	29996109
147	Phosphorylation	SPTSESPSKGFGSFI CCCCCCCCCCCHHHH	55.48	29996109
152	Phosphorylation	SPSKGFGSFINNHIL CCCCCCHHHHHHCEE	22.23	25720772
163	Phosphorylation	NHILHKNTSSHPSSP HCEECCCCCCCCCCC	36.09	21712547
164	Phosphorylation	HILHKNTSSHPSSPV CEECCCCCCCCCCCC	35.72	21712547
165	Phosphorylation	ILHKNTSSHPSSPVN EECCCCCCCCCCCCC	37.06	21712547
168	Phosphorylation	KNTSSHPSSPVNGKS CCCCCCCCCCCCCCC	41.68	24763107
169	Phosphorylation	NTSSHPSSPVNGKSS CCCCCCCCCCCCCCC	37.00	21712547
181	Phosphorylation	KSSDIHKSQSYQHLK CCCCCCHHHHHHHHH	15.36	21712547
183	Phosphorylation	SDIHKSQSYQHLKNS CCCCHHHHHHHHHCC	33.57	24763107
184	Phosphorylation	DIHKSQSYQHLKNSP CCCHHHHHHHHHCCC	7.72	29996109
190	Phosphorylation	SYQHLKNSPPNSRTA HHHHHHCCCCCCCCC	39.90	28889911
194	Phosphorylation	LKNSPPNSRTARKPV HHCCCCCCCCCCCCC	36.46	25720772
207	Phosphorylation	PVPRRANSASHNLGS CCCCCCCCCCCCCCC	30.11	29996109
209	Phosphorylation	PRRANSASHNLGSTK CCCCCCCCCCCCCCC	16.84	29996109
214	Phosphorylation	SASHNLGSTKSPNGN CCCCCCCCCCCCCCC	35.51	29996109
215	Phosphorylation	ASHNLGSTKSPNGNA CCCCCCCCCCCCCCH	33.47	29996109
217	Phosphorylation	HNLGSTKSPNGNAKE CCCCCCCCCCCCHHH	24.56	29996109
225	Phosphorylation	PNGNAKESLSRSAEL CCCCHHHHHHHCCCC	30.82	24763107
227	Phosphorylation	GNAKESLSRSAELPS CCHHHHHHHCCCCCC	33.21	21712547
229	Phosphorylation	AKESLSRSAELPSKA HHHHHHHCCCCCCCC	23.79	21712547
250	Phosphorylation	NGYRKKPSPLSPNSS CCCCCCCCCCCCCCC	47.56	28889911
253	Phosphorylation	RKKPSPLSPNSSIRN CCCCCCCCCCCCCCC	25.97	28889911
256	Phosphorylation	PSPLSPNSSIRNREG CCCCCCCCCCCCCCC	30.44	25720772
257	Phosphorylation	SPLSPNSSIRNREGG CCCCCCCCCCCCCCC	32.01	29996109
276	Phosphorylation	FDGPLTASPTPSSPT CCCCCCCCCCCCCCC	24.87	21712547
292	Phosphorylation	TPNSMSKSPSLSSLA CCCCCCCCCCHHHHH	16.65	24763107
294	Phosphorylation	NSMSKSPSLSSLAST CCCCCCCCHHHHHHC	48.23	24763107
296	Phosphorylation	MSKSPSLSSLASTGA CCCCCCHHHHHHCCC	27.87	24763107
297	Phosphorylation	SKSPSLSSLASTGAS CCCCCHHHHHHCCCC	32.99	24763107
300	Phosphorylation	PSLSSLASTGASYRP CCHHHHHHCCCCCCC	32.44	21712547
301	Phosphorylation	SLSSLASTGASYRPG CHHHHHHCCCCCCCC	31.03	25720772
304	Phosphorylation	SLASTGASYRPGPSK HHHHCCCCCCCCCCC	24.03	25720772
305	Phosphorylation	LASTGASYRPGPSKP HHHCCCCCCCCCCCC	21.94	24763107
310	Phosphorylation	ASYRPGPSKPLVSRV CCCCCCCCCCCHHHH	53.47	24763107
376	Phosphorylation	SGKSSMKSDDNVGSS CCCCCCCCCCCCCCC	41.37	27738172
383	Phosphorylation	SDDNVGSSANTAPNS CCCCCCCCCCCCCCC	21.43	27738172
392	Phosphorylation	NTAPNSPTSANSSEG CCCCCCCCCCCCCCC	40.05	27738172
396	Phosphorylation	NSPTSANSSEGNQGN CCCCCCCCCCCCCCC	29.50	27738172
425	Phosphorylation	EIPRKLKSGFIPPYA HCCHHHHCCCCCHHH	49.74	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KJ45_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KJ45_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KJ45_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of KJ45_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-94 AND SER-253, AND MASSSPECTROMETRY.
PubMed: 18257517