NAH2_SCHPO - dbPTM
NAH2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NAH2_SCHPO
UniProt AC O14123
Protein Name Probable Na(+)/H(+) antiporter C3A11.09
Gene Name sod22
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 759
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Sodium export from cell, takes up external protons in exchange for internal sodium ions..
Protein Sequence MAWSQVEISKPHLAYAIIGGFTSLFMLCSLIIKEKLFLGEATMATATGLIFGPYVAKLFVPTSWGNTDYITEELARVLLVVEVFAAGAELPRAYMLRHWRSMFVMLLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGKGKFARRVPGHLRNMLLAESGCNDGMAIPFLYLAIYLIIEKPARHAGRDWVCIIILYECTFGCVLGAIIGVIARKMIKFSERRGLMDRESFLVFYFVLALFCGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDLLLNLSFFVYVGAIMPWPQFHMPHMDLSVWRLVVLAICILIARRIPAVLLFKSFVPDIINWREALFAGHFGPIGVGALYTCLVARAELEVHSTVPEPNDAIENPEIPNWYCIQVMWPVVCFLVLSSIIVHGSSIAFFMLGKRINTLALSFTRTRDSHFAFNLPRVRQGQSLPIKRVDALRSSANSIASSIRRRHPVNIQEDEDADISTVSLPEAAHLREERAESPRGGHYDAEEFPSEDYESRQPRRSNEEDREEEMNPGDETYLIGEDLVVEDSQGNIISHTSSRDANGPSIDEKLAQGDPKAKSFGRKFRSFLRRSYDTFQRNLHEPDDERQREPTLGHIESSIENHRPRYSRQNSESHLRENSVERRRREQVLTNIGDSESEDDNIPRPGIVPFYNENNESSSDTRNGLLSDNVSESRSRRPSRAPSAAVSSEGSPVEEDNEAQHRPNIRFLELTRAWE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
442PhosphorylationMLGKRINTLALSFTR
HHCCCCCEEEHHEEC		15.8428889911
446PhosphorylationRINTLALSFTRTRDS
CCCEEEHHEECCCCC		20.9728889911
448PhosphorylationNTLALSFTRTRDSHF
CEEEHHEECCCCCCC		27.9628889911
450PhosphorylationLALSFTRTRDSHFAF
EEHHEECCCCCCCCC		35.4525720772
453PhosphorylationSFTRTRDSHFAFNLP
HEECCCCCCCCCCCC		19.7428889911
467PhosphorylationPRVRQGQSLPIKRVD
CCCCCCCCCCCHHHH		42.8329996109
478PhosphorylationKRVDALRSSANSIAS
HHHHHHHHHHHHHHH		34.3525720772
479PhosphorylationRVDALRSSANSIASS
HHHHHHHHHHHHHHH		25.6525720772
482PhosphorylationALRSSANSIASSIRR
HHHHHHHHHHHHHHH		21.1725720772
485PhosphorylationSSANSIASSIRRRHP
HHHHHHHHHHHHHCC		25.3225720772
486PhosphorylationSANSIASSIRRRHPV
HHHHHHHHHHHHCCC		15.8725720772
504PhosphorylationEDEDADISTVSLPEA
CCCCCCCCCCCCHHH		24.2529996109
507PhosphorylationDADISTVSLPEAAHL
CCCCCCCCCHHHHHH		37.9929996109
534PhosphorylationYDAEEFPSEDYESRQ
CCHHHCCCCCCCCCC		48.7129996109
537PhosphorylationEEFPSEDYESRQPRR
HHCCCCCCCCCCCCC		16.2629996109
539PhosphorylationFPSEDYESRQPRRSN
CCCCCCCCCCCCCCC		29.9529996109
589PhosphorylationSRDANGPSIDEKLAQ
CCCCCCCCHHHHHHC		44.0325720772
610PhosphorylationSFGRKFRSFLRRSYD
HHHHHHHHHHHHHHH		31.5925720772
679PhosphorylationVLTNIGDSESEDDNI
HHHHCCCCCCCCCCC		37.5027738172
681PhosphorylationTNIGDSESEDDNIPR
HHCCCCCCCCCCCCC		50.7227738172
699N-linked_GlycosylationVPFYNENNESSSDTR
CCCCCCCCCCCCCCC		44.33-
711PhosphorylationDTRNGLLSDNVSESR
CCCCCCCCCCCCHHH		31.9825720772
713N-linked_GlycosylationRNGLLSDNVSESRSR
CCCCCCCCCCHHHCC		35.52-
715PhosphorylationGLLSDNVSESRSRRP
CCCCCCCCHHHCCCC		35.7929996109
717PhosphorylationLSDNVSESRSRRPSR
CCCCCCHHHCCCCCC		28.2225720772
719PhosphorylationDNVSESRSRRPSRAP
CCCCHHHCCCCCCCC		41.7525720772
727PhosphorylationRRPSRAPSAAVSSEG
CCCCCCCCCCCCCCC		28.0725720772
731PhosphorylationRAPSAAVSSEGSPVE
CCCCCCCCCCCCCCC		20.2525720772
732PhosphorylationAPSAAVSSEGSPVEE
CCCCCCCCCCCCCCC		39.1029996109
735PhosphorylationAAVSSEGSPVEEDNE
CCCCCCCCCCCCCCC		23.0128889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NAH2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NAH2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NAH2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NAH2_SCHPO !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NAH2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-442; SER-446; THR-448AND SER-735, AND MASS SPECTROMETRY.

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