RNG2_SCHPO - dbPTM
RNG2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNG2_SCHPO
UniProt AC O14188
Protein Name Ras GTPase-activating-like protein rng2
Gene Name rng2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1489
Subcellular Localization Cytoplasm, cytoskeleton. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Localized to the F-actin ring and spindle pole body during interphase and mitosis. Also found in septum.
Protein Description Required for cytokinesis. Component of the contractile F-actin ring; required for its construction following assembly of F-actin at the division site..
Protein Sequence MDVNVGLSRLQSQAGAPVGTKGSNTRLAAKQRETLQAYDYLCRVDEAKKWIEECLGTDLGPTSTFEQSLRNGVVLALLVQKFQPDKLIKIFYSNELQFRHSDNINKFLDFIHGIGLPEIFHFELTDIYEGKNLPKVIYCIHALSYFLSMQDLAPPLIKSDENLSFTDEDVSIIVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHARFQTLNSSDSASIYSSPYTSPTLEFSKKDASARSDILKMHRRTKSATPSLEQFNEPYKQTLPSHSIEFEDSFFQPPSQKGHMQRSFLTTFSAPTRRREALFSTTSGLSQRSPVDEKIVNAIQACGRGVLVRLRLVDMLQSLVEQSSSVVLLQAVIRGYISRNTYRIRKKAYDELVNWVTSIQSISRAYLIRAQYRKVVLQEEATKSIQTLQSIIRGGFYRRKYHSLIERLDLFTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIPLFNRMQSILRANMFRNEWSNFLDSVQSFPVSFHSICKGRLIRDSINRLNGSLLGELDNFIKLQNLSRGFMIRRAFKEKLEKLKASTSSFIALQAIVRAFLLRKNLESIYDSFQKSHLSVIKAQSLYRGFITRTKIDYCNDYLLKRLPDIVFMQSAVRAILLRDDVNYTEVQLDSFIPEIVLLQSLIRGYLSRNKFSRKLQNFHKNMENPIVAKSIFRGRQEGLAYRELATAKNPPVMTVKNFVHLLDDTNFDFEEEVLLEKMRKEIVQQVRDNEEIEVHINELDVKIALLVKNKISLDDVLKHHNKYKFGKQSTEYLKINTLSMKSLNNSSRKFLELYQCFFYVLQTNEMYLANYFQALKTEGTSSVKIRHAVYLVLQIFGHGSNRREEVLLLRFISQVIKLEAALVNSSQDLLSDDCVWKLLFTGYRGDVREVKLWKTILGRIHKVLVADNHLDFEINPLTLFKSFNPEVASQTDSPKLTLSLAMQHPPTRNLYVSRLRELRKLCQSFLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEEIFGVIGKFVYWAYVAPVLVSPDNFKLVDGSITALQRKNLYTLSSILSEIFSIESCDSKQLGFFRPLSEFIEVSKQDTMLMLERLVDVVDPEVYFEFDAFEDLVNTKRPVIYMKRDDILGIYSSIAYVIDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCTIENPVAQERTLIVQTKRYILFIIRIQNGLNLLEILVKPVTDSDEAAWQNLLAEESEKNARNYDLFDDSIFSMSFAELKYTALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKSRRRMQRQRELDAGHQSLLNLREKRAFLDSQLKSYNEYIEQAMETLQSKKGKKKLIPFSKQYFHMRDLRKSGRVPRFGSFKYPALKLYDRGVLVSISHMPQKEKLYITISADEVGKFILEATSPTVKVSSPRCELHLDDLLSAQYNKVLTLDVLDGRLKLNTNMFLHLIFSKFYS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20PhosphorylationQAGAPVGTKGSNTRL
CCCCCCCCCCHHHHH		32.2521712547
23PhosphorylationAPVGTKGSNTRLAAK
CCCCCCCHHHHHHHH		36.2628889911
25PhosphorylationVGTKGSNTRLAAKQR
CCCCCHHHHHHHHHH		28.8524763107
199PhosphorylationADFMLRASPVSSRTP
CCEEHHCCCCCCCCC		21.2825720772
202PhosphorylationMLRASPVSSRTPSPT
EHHCCCCCCCCCCCC		19.9325720772
203PhosphorylationLRASPVSSRTPSPTR
HHCCCCCCCCCCCCC		40.1725720772
205PhosphorylationASPVSSRTPSPTRFP
CCCCCCCCCCCCCCC		30.0225720772
207PhosphorylationPVSSRTPSPTRFPKH
CCCCCCCCCCCCCCC		37.9929996109
209PhosphorylationSSRTPSPTRFPKHAR
CCCCCCCCCCCCCCC		49.6425720772
230PhosphorylationSDSASIYSSPYTSPT
CCCCCCCCCCCCCCC		24.1421712547
235PhosphorylationIYSSPYTSPTLEFSK
CCCCCCCCCCEECCC		15.2821712547
258PhosphorylationILKMHRRTKSATPSL
HHHHHHHCCCCCCCH		29.3425720772
260PhosphorylationKMHRRTKSATPSLEQ
HHHHHCCCCCCCHHH		36.4425720772
262PhosphorylationHRRTKSATPSLEQFN
HHHCCCCCCCHHHHC		22.0929996109
264PhosphorylationRTKSATPSLEQFNEP
HCCCCCCCHHHHCCC		39.9429996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNG2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNG2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNG2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CALM_SCHPOcam1physical
9635188
MLR4_SCHPOcdc4genetic
9635188
MYO2_SCHPOmyo2genetic
9635188
FIMB_SCHPOfim1physical
19713940
MLR4_SCHPOcdc4physical
20603077
CDC15_SCHPOcdc15physical
20603077
RAD24_SCHPOrad24physical
20603077
TOM70_SCHPOtom70physical
20603077
ODPX_SCHPOpdx1physical
20603077
RIR1_SCHPOcdc22physical
20603077
NOG1_SCHPOnog1physical
20603077
GRN1_SCHPOgrn1physical
20603077
SYNC_SCHPOnrs1physical
20603077
SAR1_SCHPOsar1physical
20603077
SYG_SCHPOgrs1physical
20603077
SYA_SCHPOala1physical
20603077
YNY5_SCHPOSPBC1711.05physical
20603077
DYR_SCHPOdfr1physical
20603077
ELF1_SCHPOelf1physical
20603077
PRS7_SCHPOrpt1physical
20603077
RS26B_SCHPOrps2602physical
20603077
RRS1_SCHPOrrs1physical
20603077
ARF1_SCHPOarf1physical
20603077
EIF3M_SCHPOSPAC1751.03physical
20603077
NOG2_SCHPOSPAC6F6.03cphysical
20603077
GCN1_SCHPOSPAC18G6.05cphysical
20603077
MS116_SCHPOSPBC691.04physical
20603077
MID1_SCHPOmid1physical
21376600
MID1_SCHPOmid1physical
21376595
MID1_SCHPOmid1physical
21422229
MYO2_SCHPOmyo2physical
21422229
MLR4_SCHPOcdc4physical
21422229
MID1_SCHPOmid1physical
22427686
MOB1_SCHPOmob1genetic
10769201
MLR4_SCHPOcdc4physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNG2_SCHPO

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Related Literatures of Post-Translational Modification

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