MYO2_SCHPO - dbPTM
MYO2_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MYO2_SCHPO
UniProt AC Q9USI6
Protein Name Myosin type-2 heavy chain 1
Gene Name myo2
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1526
Subcellular Localization
Protein Description Required for cell division. It is a component of the cdc12 'spot', a structure thought to mark the site of septation. May work in conjunction with myo3..
Protein Sequence MTEVISNKITAKDGATSLKDIDDKRWVWISDPETAFTKAWIKEDLPDKKYVVRYNNSRDEKIVGEDEIDPVNPAKFDRVNDMAELTYLNEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGLPIYTKDIIQLYKDKTQERKLPHVFAIADLAYNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIASSTTVGSSQVEEQIIKTNPVLESFGNARTVRNNNSSRFGKFIKVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYHVFYQLLSGADTALKNKLLLTDNCNDYRYLKDSVHIIDGVDDKEEFKTLLAAFKTLGFDDKENFDLFNILSIILHMGNIDVGADRSGIARLLNPDEIDKLCHLLGVSPELFSQNLVRPRIKAGHEWVISARSQTQVISSIEALAKAIYERNFGWLVKRLNTSLNHSNAQSYFIGILDIAGFEIFEKNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYMKEEIVWDFIDFGHDLQPTIDLIEKANPIGILSCLDEECVMPKATDATFTSKLDALWRNKSLKYKPFKFADQGFILTHYAADVPYSTEGWLEKNTDPLNENVAKLLAQSTNKHVATLFSDYQETETKTVRGRTKKGLFRTVAQRHKEQLNQLMNQFNSTQPHFIRCIVPNEEKKMHTFNRPLVLGQLRCNGVLEGIRITRAGFPNRLPFNDFRVRYEIMAHLPTGTYVESRRASVMILEELKIDEASYRIGVSKIFFKAGVLAELEERRVATLQRLMTMLQTRIRGFLQRKIFQKRLKDIQAIKLLQANLQVYNEFRTFPWAKLFFNLRPLLSSTQNDKQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTAVENLLTTERAIALDKEEILRRTQERLANIEDSFSETKQQNENLQRESASLKQINNELESELLEKTSKVETLLSEQNELKEKLSLEEKDLLDTKGELESLRENNATVLSEKAEFNEQCKSLQETIVTKDAELDKLTKYISDYKTEIQEMRLTNQKMNEKSIQQEGSLSESLKRVKKLERENSTLISDVSILKQQKEELSVLKGVQELTINNLEEKVNYLEADVKQLPKLKKELESLNDKDQLYQLQATKNKELEAKVKECLNNIKSLTKELENKEEKCQNLSDASLKYIELQEIHENLLLKVSDLENYKKKYEGLQLDLEGLKDVDTNFQELSKKHRDLTFNHESLLRQSASYKEKLSLASSENKDLSNKVSSLTKQVNELSPKASKVPELERKITNLMHEYSQLGKTFEDEKRKALIASRDNEELRSLKSELESKRKLEVEYQKVLEEVKTTRSLRSEVTLLRNKVADHESIRSKLSEVEMKLVDTRKELNSALDSCKKREAEIHRLKEHRPSGKENNIPAVKTTEPVLKNIPQRKTIFDLQQRNANQALYENLKRDYDRLNLEKHNLEKQVNELKGAEVSPQPTGQSLQHVNLAHAIELKALKDQINSEKAKMFSVQVQYEKREQELQKRIASLEKVNKDSLIDVRALRDRIASLEDELRAA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationTAKDGATSLKDIDDK
ECCCCCCCCCCCCCC		32.6525720772
400PhosphorylationEWVISARSQTQVISS
EEEEECCCHHHHHHH		36.9825720772
402PhosphorylationVISARSQTQVISSIE
EEECCCHHHHHHHHH		26.5025720772
1044PhosphorylationKKLERENSTLISDVS
HHHHHHHCCCHHHHH		21.6028889911
1045PhosphorylationKLERENSTLISDVSI
HHHHHHCCCHHHHHH		39.4328889911
1444PhosphorylationELKGAEVSPQPTGQS
HHCCCCCCCCCCCCC		14.8824763107
1448PhosphorylationAEVSPQPTGQSLQHV
CCCCCCCCCCCCCCC		42.4821712547
1451PhosphorylationSPQPTGQSLQHVNLA
CCCCCCCCCCCCCHH		31.2021712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MYO2_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MYO2_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MYO2_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MYO3_SCHPOmyp2genetic
10769212
SID2_SCHPOsid2genetic
11739799
CDC7_SCHPOcdc7genetic
11739799
CDC16_SCHPOcdc16genetic
11739799
CDC11_SCHPOcdc11genetic
11739799
SID4_SCHPOsid4genetic
11739799
SPG1_SCHPOspg1genetic
11739799
MLR4_SCHPOcdc4genetic
10022828
MLR4_SCHPOcdc4physical
10769212
MLR4_SCHPOcdc4physical
10022828
MLR1_SCHPOrlc1physical
11069761
MLR4_SCHPOcdc4physical
15504913
MLR1_SCHPOrlc1physical
15504913
CAM2_SCHPOcam2physical
15504913
RNG3_SCHPOrng3physical
15755919
HSP90_SCHPOhsp90physical
15755919
MLR1_SCHPOrlc1genetic
19570908
MLR1_SCHPOrlc1physical
19570908
MYO1_SCHPOmyo1physical
19805578
RNG2_SCHPOrng2physical
19805578
MYO3_SCHPOmyp2physical
19805578
MYO2_SCHPOmyo2physical
19805578
MYO52_SCHPOmyo52physical
19805578
CHS2_SCHPOchs2genetic
16772338
MYO3_SCHPOmyp2genetic
16772338
MID1_SCHPOmid1physical
21422229
MYO3_SCHPOmyp2genetic
22275432
MID1_SCHPOmid1physical
22427686
MOB1_SCHPOmob1genetic
10769201
MYO51_SCHPOmyo51genetic
23185032
DNT1_SCHPOdnt1genetic
17538026
RRN5_SCHPOrrn5genetic
17538026
RPA1_SCHPOnuc1genetic
17538026
MLR4_SCHPOcdc4physical
11056543
MYO3_SCHPOmyp2genetic
23770677
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MYO2_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1044, AND MASSSPECTROMETRY.

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