DNT1_SCHPO - dbPTM
DNT1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DNT1_SCHPO
UniProt AC O74354
Protein Name Nucleolar protein dnt1
Gene Name dnt1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 599
Subcellular Localization Cytoplasm. Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. In late anaphase, localizes to the ends of the mitotic spindle.
Protein Description Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1..
Protein Sequence MRTTLRLHIIKDGEQDNQFMILFDPSSSISLLKEKVQETYKSLYPFESNINIRNIKNEESYDIPNEYLVGEIFPTNSKVIVESFSSPLKKLDGTMINFKEKNIQHDLDGVENDFATVQSASNGVHAINGKRTHPDESENPRKLPKKNFVEAIDANSPGFVYRPTSIRDRAYSISSNHDNESTLTEGIALKEIESPDKDRKADGIVNLSVTQEEDDNHQSFNSSLTPSQPTTYNRANFFSINDASSDSSSDAPLRTLSSPSRLRMKDNDRKYLVEHSPAALIKESETIDGIDDKSLRSSTREVSVESPNEDSVNDDSSSDVSDEKETEAKHEIRAPAIIVRETSSHPSTAVPSENDTTESENDTLSESSTTSISSSPSENSDTSDDLTKVDSPNKSLVNDNVSAKHDKESENGKSKFPPPSQTLVTTSTISAAGNEPSDEIGSENDSDSDSDSDSSVPLSQLQKKSQQRNSVSHEIQNRGTKGSPKEPKAKPSTERPETHRTLSYSRLSELSKTFSPEIREPSLTKKTAVSMQESKEEGRSDESSESEESGSSSDESDNSEKEDRSNPIPVEKRASTVLNTKKKRKAKRNSALAGLAALV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
86PhosphorylationVIVESFSSPLKKLDG
EEEEECCCCHHHCCC		32.0429996109
119PhosphorylationNDFATVQSASNGVHA
CCHHHHHHHCCCEEE		29.3621712547
156PhosphorylationVEAIDANSPGFVYRP
HHHCCCCCCCEEECC		28.2821712547
161PhosphorylationANSPGFVYRPTSIRD
CCCCCEEECCCCHHH		14.4921712547
171PhosphorylationTSIRDRAYSISSNHD
CCHHHCCEECCCCCC		13.8729996109
172PhosphorylationSIRDRAYSISSNHDN
CHHHCCEECCCCCCC		18.2728889911
174PhosphorylationRDRAYSISSNHDNES
HHCCEECCCCCCCCC		21.1028889911
175PhosphorylationDRAYSISSNHDNEST
HCCEECCCCCCCCCC		36.1929996109
181PhosphorylationSSNHDNESTLTEGIA
CCCCCCCCCCCCCEE		34.6621712547
182PhosphorylationSNHDNESTLTEGIAL
CCCCCCCCCCCCEEE		31.3629996109
184PhosphorylationHDNESTLTEGIALKE
CCCCCCCCCCEEEEE		32.0529996109
194PhosphorylationIALKEIESPDKDRKA
EEEEECCCCCCCCCC		44.0221712547
210PhosphorylationGIVNLSVTQEEDDNH
CEEEEEEECCCCCCC		27.2129996109
219PhosphorylationEEDDNHQSFNSSLTP
CCCCCCCCCCCCCCC		20.8829996109
223PhosphorylationNHQSFNSSLTPSQPT
CCCCCCCCCCCCCCC		37.0529996109
225PhosphorylationQSFNSSLTPSQPTTY
CCCCCCCCCCCCCCC		23.8929996109
244PhosphorylationFFSINDASSDSSSDA
CEECCCCCCCCCCCC		37.2325720772
245PhosphorylationFSINDASSDSSSDAP
EECCCCCCCCCCCCC		43.1428889911
247PhosphorylationINDASSDSSSDAPLR
CCCCCCCCCCCCCCC		33.4225720772
248PhosphorylationNDASSDSSSDAPLRT
CCCCCCCCCCCCCCC		36.9125720772
249PhosphorylationDASSDSSSDAPLRTL
CCCCCCCCCCCCCCC		41.5728889911
255PhosphorylationSSDAPLRTLSSPSRL
CCCCCCCCCCCCCCE		38.3825720772
257PhosphorylationDAPLRTLSSPSRLRM
CCCCCCCCCCCCEEC		39.3225720772
258PhosphorylationAPLRTLSSPSRLRMK
CCCCCCCCCCCEECC		29.9725720772
260PhosphorylationLRTLSSPSRLRMKDN
CCCCCCCCCEECCCC		45.9925720772
276PhosphorylationRKYLVEHSPAALIKE
CCHHEECCHHHHHCC		11.6128889911
294PhosphorylationIDGIDDKSLRSSTRE
CCCCCCHHHHCCCCE		35.6925720772
297PhosphorylationIDDKSLRSSTREVSV
CCCHHHHCCCCEEEE		41.1625720772
306PhosphorylationTREVSVESPNEDSVN
CCEEEECCCCCCCCC		30.7628889911
311PhosphorylationVESPNEDSVNDDSSS
ECCCCCCCCCCCCCC		19.3525720772
316PhosphorylationEDSVNDDSSSDVSDE
CCCCCCCCCCCCCCH		34.3125720772
317PhosphorylationDSVNDDSSSDVSDEK
CCCCCCCCCCCCCHH		37.2425720772
318PhosphorylationSVNDDSSSDVSDEKE
CCCCCCCCCCCCHHH		46.0827738172
391PhosphorylationDDLTKVDSPNKSLVN
CCCCCCCCCCCCCCC		33.1029996109
395PhosphorylationKVDSPNKSLVNDNVS
CCCCCCCCCCCCCCC		44.1624763107
470PhosphorylationKKSQQRNSVSHEIQN
HHHHHHHHHHHHHHH		27.4729996109
472PhosphorylationSQQRNSVSHEIQNRG
HHHHHHHHHHHHHCC		18.4129996109
501PhosphorylationERPETHRTLSYSRLS
CCCCHHHCCCHHHHH		16.6725720772
503PhosphorylationPETHRTLSYSRLSEL
CCHHHCCCHHHHHHH		22.0528889911
504PhosphorylationETHRTLSYSRLSELS
CHHHCCCHHHHHHHH		10.8325720772
505PhosphorylationTHRTLSYSRLSELSK
HHHCCCHHHHHHHHH		24.3028889911
508PhosphorylationTLSYSRLSELSKTFS
CCCHHHHHHHHHHCC		35.0725720772
513PhosphorylationRLSELSKTFSPEIRE
HHHHHHHHCCHHHCC		26.4328889911
515PhosphorylationSELSKTFSPEIREPS
HHHHHHCCHHHCCCC		27.1928889911
522PhosphorylationSPEIREPSLTKKTAV
CHHHCCCCCCHHHEE		43.8721712547
575PhosphorylationIPVEKRASTVLNTKK
CCHHHHHHHHHCHHH		24.0721712547
590PhosphorylationKRKAKRNSALAGLAA
HHHHHHHHHHHHHHH		28.7924763107
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DNT1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DNT1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DNT1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RRN5_SCHPOrrn5genetic
17538026
RPA1_SCHPOnuc1genetic
17538026
DMA1_SCHPOdma1physical
22809626
DMA1_SCHPOdma1genetic
22809626
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DNT1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-174; SER-306 ANDTHR-513, AND MASS SPECTROMETRY.

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