RRN5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRN5_SCHPO
• UniProt AC: O14013
• Protein Name: RNA polymerase I-specific transcription initiation factor rrn5
• Gene Name: rrn5
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 556
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level..
• Protein Sequence: MSSSINGLNESEGSTPLSTASIIGSSEQLYMTHDERYLDVLQQYEVETENKRDFDLEEEQWGVLSGSCVDGTYWSAEEKELFFQAVARNGKRDLDLIAYSIPSKSAVQIERYINALENELRWLRNHVDASVRSQCLLKYEDIPIAMEMSQNWIDWEEKIAERLLEGSNISGVETSHYNAQSVKNKTSNEDLFDTNEMRKISERFYHFDRQAPFPSNPLSAGATEFLLQIIKSKLKELIGTSIFLAESRFRKLEANNAFHRKPIIKNRDVVLSGKFLRFHRFNIPGFWKYLPTRQKMNVYKRNKRLKFQNYIHIMESDERQSKLKLGRVRARKTKNNENTMFFDSKEHSTDESDGNLGEHDVKRKVDSVPADETSINGFKKSVNQAEYPDNAQMFMDESVAEESLVEIDDSVEAYDMIQSKNYESFVWKYVLHLTDEMSTEDALFETIPLSNLLAQKRMKDKLKGSDVFTTLKITSKSLHNIDEHSDSDDEVQPICYYYKDPVVSHAPGAAEVVSELESGYVGLISYDLSNLPNSTEDPERKLAKPVSSWELSLPLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
99	Phosphorylation	RDLDLIAYSIPSKSA CCCEEEEEECCCCCH	10.51	21712547
100	Phosphorylation	DLDLIAYSIPSKSAV CCEEEEEECCCCCHH	20.99	21712547
103	Phosphorylation	LIAYSIPSKSAVQIE EEEEECCCCCHHHHH	37.26	21712547
348	Phosphorylation	FFDSKEHSTDESDGN CEECCCCCCCCCCCC	38.35	21712547
349	Phosphorylation	FDSKEHSTDESDGNL EECCCCCCCCCCCCC	45.77	21712547
352	Phosphorylation	KEHSTDESDGNLGEH CCCCCCCCCCCCCHH	54.34	21712547
485	Phosphorylation	LHNIDEHSDSDDEVQ HCCCCCCCCCCCCCC	36.44	21712547
487	Phosphorylation	NIDEHSDSDDEVQPI CCCCCCCCCCCCCEE	50.40	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRN5_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRN5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRN5_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of RRN5_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.