| UniProt ID | SID4_SCHPO | |
|---|---|---|
| UniProt AC | O60187 | |
| Protein Name | Septation initiation protein sid4 | |
| Gene Name | sid4 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 660 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body . | |
| Protein Description | Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach.. | |
| Protein Sequence | MDEAFGDSLSTDYRWLGHSHFDSHPSAGDSIYFDSLDEDADPSRTARIDRIAELLDGLNDEQISELVNGVNSTTIKENTKKEISNPNDSTRLPLEQIPGSNNLFLDPRHQLGDNSQNAQRHHEPSFNSEKASYTSTPYKNVAPKVIDSPSARHMHSNSPSFPPSQSHTSSYDQSPKGQLRDNISVPNQQDGLDPEVFNQQSKETKKSLQVPPSRNVPPPVTRPNQYNPEPNFSLSSGYPQQHFSQPELQNRNVHLETVPESYPVPPSGYPLTSSTCVSSISQPIQSTDCQKAQENLSNNKQMSSNDQDIDPFKQAITDLPPSFVNIVLEMNATIQSLSNQCQQRDKQIENITKQLLMNQQDYCPTTMSTTVSTPLCPPKRFPKSTKDFKEQKPDTKQVRSATISNDFNLKGNGRYNEKSQIAVPSEIRVQLSTLDAILLQFEHLRKELTQARKEIQILRHTSQNGDQESNESSKNAITTKTTDKGNNKENTMLNDGSTAPAKNDIRNVINTNNLDAKLSDESELMIEKNKSYSTPASSTIPTFHTSQPLTSLNMPDSRFNLAKEKQLYYRLGLQHIDQQCSVETANMLKTVLVQLNIPFAIFPSTIGQVRRQLQQGRRLYQWARNIHYLIYEENMRDGLVSKQCLADMLKKIRELKKRSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 89 | Phosphorylation | EISNPNDSTRLPLEQ CCCCCCCCCCCCHHH | 23.28 | 29996109 | |
| 90 | Phosphorylation | ISNPNDSTRLPLEQI CCCCCCCCCCCHHHC | 38.80 | 29996109 | |
| 115 | Phosphorylation | RHQLGDNSQNAQRHH CHHCCCCCHHHHHHC | 29.56 | 29996109 | |
| 125 | Phosphorylation | AQRHHEPSFNSEKAS HHHHCCCCCCCCCCC | 33.79 | 29996109 | |
| 128 | Phosphorylation | HHEPSFNSEKASYTS HCCCCCCCCCCCCCC | 38.16 | 29996109 | |
| 148 | Phosphorylation | VAPKVIDSPSARHMH CCCCEECCCCHHCCC | 15.05 | 29996109 | |
| 402 | Phosphorylation | TKQVRSATISNDFNL CHHHHHEEECCCCCC | 26.61 | 29996109 | |
| 522 | Phosphorylation | DAKLSDESELMIEKN CCCCCCHHHHHHHCC | 40.81 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SID4_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SID4_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SID4_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SPG1_SCHPO | spg1 | genetic | 9649519 | |
| SID2_SCHPO | sid2 | genetic | 9649519 | |
| SCW1_SCHPO | scw1 | genetic | 12796296 | |
| ZFS1_SCHPO | zfs1 | genetic | 10462526 | |
| SCW1_SCHPO | scw1 | genetic | 12242222 | |
| PPC89_SCHPO | ppc89 | physical | 16775007 | |
| SID4_SCHPO | sid4 | physical | 16775007 | |
| CDC11_SCHPO | cdc11 | physical | 11676915 | |
| SID4_SCHPO | sid4 | physical | 10805785 | |
| PLO1_SCHPO | plo1 | physical | 15062098 | |
| SID4_SCHPO | sid4 | physical | 11950932 | |
| CDC11_SCHPO | cdc11 | physical | 11950932 | |
| ACE2_SCHPO | ace2 | genetic | 16415366 | |
| ORB6_SCHPO | orb6 | genetic | 20805322 | |
| DMA1_SCHPO | dma1 | physical | 12479804 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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