SCW1_SCHPO - dbPTM
SCW1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SCW1_SCHPO
UniProt AC O74452
Protein Name Cell wall integrity protein scw1
Gene Name scw1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 561
Subcellular Localization Cytoplasm .
Protein Description Acts as a negative regulator of cell wall and septum deposition..
Protein Sequence MFVGSPSAIEKPLSLSSKTKVGDETEFTEDALRGSSLVPTGILNGDDECHALHMSPQAIHSQAGKAESDGLPTYASVEKSTTPIGRLLSNLNGGLASAPPKVGFGFPRYYALRIEDLPRDLTPREFLCTFLFATNVVSVELNPVSVDNEVAHGLAVFSSRDAAASARDTLLSSDVYSACSMIILDNYRKGSQTNLSDETEGSESSVSFNRLSRNHSPTRPLLGNRDLFRRSSNHVSASMPTANHSESAYRHSKTPLGDSTFQAPNNGGSLHSDRLWSSFPVSYPLTLANVLAKDEVGSPTWSPTPSKSSTNLRQDGVPPILRFNSLSINTNVARNYLSSEKGYSAHTQNSSAQSPHPRVFSANSAFSTTSPPPLTPSTSRDYPFSASTISPSTPFSAYSSSHGIHQRIPASTPTNTNPADQNPPCNTIYVGNLPPSTSEEELKVLFSTQVGYKRLCFRTKGNGPMCFVEFENIPYAMEALKNLQGVCLSSSIKGGIRLSFSKNPLGVRSSSSSHNNHNGNVRNLHSGSMNNYNTDSLLNHTGGHNEVHASPSWGNNLMYGK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MFVGSPSAIEKP
---CCCCCHHHCCCC		15.4724763107
7Phosphorylation-MFVGSPSAIEKPLS
-CCCCCHHHCCCCCC		43.5025720772
14PhosphorylationSAIEKPLSLSSKTKV
HHCCCCCCCCCCCCC		34.4329996109
16PhosphorylationIEKPLSLSSKTKVGD
CCCCCCCCCCCCCCC		26.8129996109
17PhosphorylationEKPLSLSSKTKVGDE
CCCCCCCCCCCCCCC		50.0329996109
28PhosphorylationVGDETEFTEDALRGS
CCCCCCCCHHHHCCC		27.0727738172
40PhosphorylationRGSSLVPTGILNGDD
CCCCCCCCCCCCCCC		29.4029996109
55PhosphorylationECHALHMSPQAIHSQ
CCEEHHCCHHHHHHH		11.7825720772
61PhosphorylationMSPQAIHSQAGKAES
CCHHHHHHHCCCCCC		18.6621712547
68PhosphorylationSQAGKAESDGLPTYA
HHCCCCCCCCCCCCC		41.6724763107
73PhosphorylationAESDGLPTYASVEKS
CCCCCCCCCCCCCCC		36.4425720772
74PhosphorylationESDGLPTYASVEKST
CCCCCCCCCCCCCCC		8.5725720772
76PhosphorylationDGLPTYASVEKSTTP
CCCCCCCCCCCCCCH		22.0124763107
80PhosphorylationTYASVEKSTTPIGRL
CCCCCCCCCCHHHHH		24.8124763107
81PhosphorylationYASVEKSTTPIGRLL
CCCCCCCCCHHHHHH		47.8921712547
82PhosphorylationASVEKSTTPIGRLLS
CCCCCCCCHHHHHHH		21.7221712547
89PhosphorylationTPIGRLLSNLNGGLA
CHHHHHHHHCCCCCC		43.8125720772
97PhosphorylationNLNGGLASAPPKVGF
HCCCCCCCCCCCCCC		46.4821712547
191PhosphorylationLDNYRKGSQTNLSDE
HHCCCCCCCCCCCCC		36.5528889911
193PhosphorylationNYRKGSQTNLSDETE
CCCCCCCCCCCCCCC		39.5628889911
196PhosphorylationKGSQTNLSDETEGSE
CCCCCCCCCCCCCCC		35.1628889911
199PhosphorylationQTNLSDETEGSESSV
CCCCCCCCCCCCCCH		51.1129996109
202PhosphorylationLSDETEGSESSVSFN
CCCCCCCCCCCHHHH		28.2425720772
204PhosphorylationDETEGSESSVSFNRL
CCCCCCCCCHHHHHH		37.4229996109
205PhosphorylationETEGSESSVSFNRLS
CCCCCCCCHHHHHHC		20.1025720772
207PhosphorylationEGSESSVSFNRLSRN
CCCCCCHHHHHHCCC		20.8225720772
212PhosphorylationSVSFNRLSRNHSPTR
CHHHHHHCCCCCCCC		28.0029996109
216PhosphorylationNRLSRNHSPTRPLLG
HHHCCCCCCCCCCCC		31.3628889911
218PhosphorylationLSRNHSPTRPLLGNR
HCCCCCCCCCCCCCH		48.1928889911
231PhosphorylationNRDLFRRSSNHVSAS
CHHHHHHHCCCCCCC		31.1028889911
232PhosphorylationRDLFRRSSNHVSASM
HHHHHHHCCCCCCCC		29.1929996109
236PhosphorylationRRSSNHVSASMPTAN
HHHCCCCCCCCCCCC		13.6929996109
238PhosphorylationSSNHVSASMPTANHS
HCCCCCCCCCCCCCC		20.1429996109
241PhosphorylationHVSASMPTANHSESA
CCCCCCCCCCCCHHH		31.3029996109
245PhosphorylationSMPTANHSESAYRHS
CCCCCCCCHHHHHCC		32.8129996109
247PhosphorylationPTANHSESAYRHSKT
CCCCCCHHHHHCCCC		33.3529996109
252PhosphorylationSESAYRHSKTPLGDS
CHHHHHCCCCCCCCC		29.2629996109
254PhosphorylationSAYRHSKTPLGDSTF
HHHHCCCCCCCCCCC		27.1028889911
259PhosphorylationSKTPLGDSTFQAPNN
CCCCCCCCCCCCCCC		29.3529996109
260PhosphorylationKTPLGDSTFQAPNNG
CCCCCCCCCCCCCCC		25.2229996109
269PhosphorylationQAPNNGGSLHSDRLW
CCCCCCCCCCCCCCH		25.0629996109
272PhosphorylationNNGGSLHSDRLWSSF
CCCCCCCCCCCHHHC		29.7129996109
298PhosphorylationLAKDEVGSPTWSPTP
HHCCCCCCCCCCCCC		25.0828889911
300PhosphorylationKDEVGSPTWSPTPSK
CCCCCCCCCCCCCCC		40.0328889911
302PhosphorylationEVGSPTWSPTPSKSS
CCCCCCCCCCCCCCC		22.7528889911
304PhosphorylationGSPTWSPTPSKSSTN
CCCCCCCCCCCCCCC		34.3824763107
306PhosphorylationPTWSPTPSKSSTNLR
CCCCCCCCCCCCCCC		47.8821712547
308PhosphorylationWSPTPSKSSTNLRQD
CCCCCCCCCCCCCCC		46.8921712547
310PhosphorylationPTPSKSSTNLRQDGV
CCCCCCCCCCCCCCC		45.4225720772
325PhosphorylationPPILRFNSLSINTNV
CCEEEEEEEEECHHH		22.3028889911
327PhosphorylationILRFNSLSINTNVAR
EEEEEEEEECHHHHH		17.3925720772
330PhosphorylationFNSLSINTNVARNYL
EEEEEECHHHHHHHH		29.4221712547
344PhosphorylationLSSEKGYSAHTQNSS
HHCCCCCCCCCCCCC		23.4229996109
347PhosphorylationEKGYSAHTQNSSAQS
CCCCCCCCCCCCCCC		29.2129996109
350PhosphorylationYSAHTQNSSAQSPHP
CCCCCCCCCCCCCCC		19.7529996109
351PhosphorylationSAHTQNSSAQSPHPR
CCCCCCCCCCCCCCC		37.5729996109
354PhosphorylationTQNSSAQSPHPRVFS
CCCCCCCCCCCCEEC		25.5428889911
361PhosphorylationSPHPRVFSANSAFST
CCCCCEECCCCCCCC		24.5529996109
364PhosphorylationPRVFSANSAFSTTSP
CCEECCCCCCCCCCC		30.3329996109
367PhosphorylationFSANSAFSTTSPPPL
ECCCCCCCCCCCCCC		30.4129996109
368PhosphorylationSANSAFSTTSPPPLT
CCCCCCCCCCCCCCC		25.4925720772
369PhosphorylationANSAFSTTSPPPLTP
CCCCCCCCCCCCCCC		37.7329996109
370PhosphorylationNSAFSTTSPPPLTPS
CCCCCCCCCCCCCCC		35.1828889911
375PhosphorylationTTSPPPLTPSTSRDY
CCCCCCCCCCCCCCC		22.4429996109
377PhosphorylationSPPPLTPSTSRDYPF
CCCCCCCCCCCCCCC		33.5129996109
388PhosphorylationDYPFSASTISPSTPF
CCCCCCCCCCCCCCC		25.7829996109
390PhosphorylationPFSASTISPSTPFSA
CCCCCCCCCCCCCCC		16.9429996109
392PhosphorylationSASTISPSTPFSAYS
CCCCCCCCCCCCCCC		41.7529996109
393PhosphorylationASTISPSTPFSAYSS
CCCCCCCCCCCCCCC		31.5629996109
396PhosphorylationISPSTPFSAYSSSHG
CCCCCCCCCCCCCCC		27.7429996109
398PhosphorylationPSTPFSAYSSSHGIH
CCCCCCCCCCCCCCC		14.1129996109
550PhosphorylationGHNEVHASPSWGNNL
CCCCCCCCCCCCCCC		12.4629996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SCW1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SCW1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SCW1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SPN1_SCHPOspn1genetic
20739711
MID2_SCHPOmid2genetic
20739711
MYO2_SCHPOmyo2genetic
20739711
MLR4_SCHPOcdc4genetic
20739711
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SCW1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-191; THR-193; SER-196;SER-216; THR-218; SER-231; SER-298; SER-302; SER-325 AND SER-370, ANDMASS SPECTROMETRY.

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