DYR_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DYR_SCHPO
• UniProt AC: P36591
• Protein Name: Dihydrofolate reductase
• Gene Name: dfr1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 461
• Protein Description: Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)..
• Protein Sequence: MSKPLKVLCLHGWIQSGPVFSKKMGSVQKYLSKYAELHFPTGPVVADEEADPNDEEEKKRLAALGGEQNGGKFGWFEVEDFKNTYGSWDESLECINQYMQEKGPFDGLIGFSQGAGIGAMLAQMLQPGQPPNPYVQHPPFKFVVFVGGFRAEKPEFDHFYNPKLTTPSLHIAGTSDTLVPLARSKQLVERCENAHVLLHPGQHIVPQQAVYKTGIRDFMFSAPTKEPTKHPRDLTMIVAVSSPNLGIGKKNSMPWHIKQEMAYFANVTSSTESSGQLEEGKSKIMNVVIMGRSCYDSLPKKNRPLKDRINIVITRNSNYNFGLTKKEKMPENLYAADCIDSALDLVAEKYGADSDIQVGKVFIIGGSFLYGSALYHPLTKNLLFTRIHKEYPCDSFFPFEPAESSDWVRKAHPELEKFVGIPVEEGRLKAASSNKEEVEIEFELYGKNDDVNVALEKLSIC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	FDGLIGFSQGAGIGA CCCCCCCCCCCCHHH	23.61	29996109
293	Phosphorylation	NVVIMGRSCYDSLPK EEEEECCHHHHCCCC	15.99	25720772
459	Phosphorylation	NVALEKLSIC----- CHHHHHCCCC-----	32.74	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DYR_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DYR_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DYR_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of DYR_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.