dbPTM

ODPX_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ODPX_SCHPO
UniProt AC	O94709
Protein Name	Probable pyruvate dehydrogenase protein X component, mitochondrial
Gene Name	SPCC1259.09c
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	456
Subcellular Localization	Mitochondrion matrix .
Protein Description	Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity)..
Protein Sequence	MLKHYIHQCVKASSCKHSLSVKQRYFHCSALNGVASMFRMPALSPTMEEGNITKWHFKEGDSFKSGDILLEVETDKATMDVEVQDNGILAKVLIEKGSNIPVGKNIAIVADAEDNLKDLELPKDEASSEEQSFSSSKEEVKPIVQDRETKSNVEHKSTSQANDAVNKSFLPSVSYLIHQYKIENPWSIPATGPHGRLLKGDVLAHVGKIDKGVPSSLQKFVRNLEVLDFSGVEPKKPSYTEDSVPVRKSTMIETLKTVPMKDEYITFERSISLEKLKSLLAKRKEKDAFGIDEVVSAMIGDALSISELSKVEPNSIESAYDLLLGAPIVKLKSSVSNFQPKLFPKNNNTKDLHKYIRDSMIGLPSNLSDYVKLNFSSVTKSSSNNVEFLDDVYDMLLGSNSDSIDSRINRHEEPSTTEDLTLTLSIKDNISKSRAIKFVDCLKSNFENPEFVLSRW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	N6-lipoyllysine	LLEVETDKATMDVEV EEEEECCCCEEEEEE	53.85	-
76	Lipoylation	LLEVETDKATMDVEV EEEEECCCCEEEEEE	53.85	-
76	Lipoylation	LLEVETDKATMDVEV EEEEECCCCEEEEEE	53.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ODPX_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ODPX_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ODPX_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARF6_SCHPO	arf6	genetic	22681890
GLRX5_SCHPO	grx5	genetic	22681890
LIZ1_SCHPO	liz1	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ODPX_SCHPO

Related Literatures of Post-Translational Modification