CDC15_SCHPO - dbPTM
CDC15_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CDC15_SCHPO
UniProt AC Q09822
Protein Name Cell division control protein 15
Gene Name cdc15
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 927
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability..
Protein Sequence MEVNGVSQSEAAPYVTKSSVKFRDNFWGSEDAGMDALMSRTKSSLSVLESIDEFYAKRASIEREYASKLQELAASSADIPEVGSTLNNILSMRTETGSMAKAHEEVSQQINTELRNKIREYIDQTEQQKVVAANAIEELYQKKTALEIDLSEKKDAYEYSCNKLNSYMRQTKKMTGRELDKYNLKIRQAALAVKKMDAEYRETNELLLTVTREWIDRWTEVCDAFQHIEEYRLEFLKTNMWAYANIISTACVKDDESCEKIRLTLENTNIDEDITQMIQNEGTGTTIPPLPEFNDYFKENGLNYDIDQLISKAPSYPYSSSRPSASASLASSPTRSAFRPKTSETVSSEVVSSPPTSPLHSPVKPVSNEQVEQVTEVELSIPVPSIQEAESQKPVLTGSSMRRPSVTSPTFEVAARPLTSMDVRSSHNAETEVQAIPAATDISPEVKEGKNSENAITKDNDDIILSSQLQPTATGSRSSRLSFSRHGHGSQTSLGSIKRKSIMERMGRPTSPFMGSSFSNMGSRSTSPTKEGFASNQHATGASVQSDELEDIDPRANVVLNVGPNMLSVGEAPVESTSKEEDKDVPDPIANAMAELSSSMRRRQSTSVDDEAPVSLSKTSSSTRLNGLGYHSRNTSIASDIDGVPKKSTLGAPPAAHTSAQMQRMSNSFASQTKQVFGEQRTENSARESLRHSRSNMSRSPSPMLSRRSSTLRPSFERSASSLSVRQSDVVSPAPSTRARGQSVSGQQRPSSSMSLYGEYNKSQPQLSMQRSVSPNPLGPNRRSSSVLQSQKSTSSNTSNRNNGGYSGSRPSSEMGHRYGSMSGRSMRQVSQRSTSRARSPEPTNRNSVQSKNVDPRATFTAEGEPILGYVIALYDYQAQIPEEISFQKGDTLMVLRTQEDGWWDGEIINVPNSKRGLFPSNFVQTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
41PhosphorylationMDALMSRTKSSLSVL
HHHHHHCCHHHHHHH		28.1525720772
43PhosphorylationALMSRTKSSLSVLES
HHHHCCHHHHHHHHH		35.5821712547
44PhosphorylationLMSRTKSSLSVLESI
HHHCCHHHHHHHHHH		26.6429996109
46PhosphorylationSRTKSSLSVLESIDE
HCCHHHHHHHHHHHH		26.9721712547
50PhosphorylationSSLSVLESIDEFYAK
HHHHHHHHHHHHHHH		31.0425720772
315PhosphorylationQLISKAPSYPYSSSR
HHHHHCCCCCCCCCC		43.5329996109
316PhosphorylationLISKAPSYPYSSSRP
HHHHCCCCCCCCCCC		12.7229996109
318PhosphorylationSKAPSYPYSSSRPSA
HHCCCCCCCCCCCCC		16.9829996109
319PhosphorylationKAPSYPYSSSRPSAS
HCCCCCCCCCCCCCC		19.8229996109
320PhosphorylationAPSYPYSSSRPSASA
CCCCCCCCCCCCCCH		25.2329996109
321PhosphorylationPSYPYSSSRPSASAS
CCCCCCCCCCCCCHH		42.1229996109
324PhosphorylationPYSSSRPSASASLAS
CCCCCCCCCCHHHCC		33.4725720772
326PhosphorylationSSSRPSASASLASSP
CCCCCCCCHHHCCCC		23.8021712547
328PhosphorylationSRPSASASLASSPTR
CCCCCCHHHCCCCCC		23.2125720772
331PhosphorylationSASASLASSPTRSAF
CCCHHHCCCCCCCCC		41.9928889911
332PhosphorylationASASLASSPTRSAFR
CCHHHCCCCCCCCCC		25.3628889911
334PhosphorylationASLASSPTRSAFRPK
HHHCCCCCCCCCCCC		38.9229996109
336PhosphorylationLASSPTRSAFRPKTS
HCCCCCCCCCCCCCC		33.9527738172
353PhosphorylationVSSEVVSSPPTSPLH
CCHHHCCCCCCCCCC		24.2424763107
357PhosphorylationVVSSPPTSPLHSPVK
HCCCCCCCCCCCCCC		31.1027738172
361PhosphorylationPPTSPLHSPVKPVSN
CCCCCCCCCCCCCCH		38.7921712547
405PhosphorylationGSSMRRPSVTSPTFE
CCCCCCCCCCCCCCE		35.8925720772
407PhosphorylationSMRRPSVTSPTFEVA
CCCCCCCCCCCCEEE		33.0725720772
408PhosphorylationMRRPSVTSPTFEVAA
CCCCCCCCCCCEEEC		21.5625720772
410PhosphorylationRPSVTSPTFEVAARP
CCCCCCCCCEEECEE		31.9929996109
419PhosphorylationEVAARPLTSMDVRSS
EEECEECCCCCCCCC		25.3725720772
420PhosphorylationVAARPLTSMDVRSSH
EECEECCCCCCCCCC		22.2229996109
425PhosphorylationLTSMDVRSSHNAETE
CCCCCCCCCCCCHHH		35.4825720772
426PhosphorylationTSMDVRSSHNAETEV
CCCCCCCCCCCHHHE		15.3628889911
431PhosphorylationRSSHNAETEVQAIPA
CCCCCCHHHEEECCC		38.7625720772
440PhosphorylationVQAIPAATDISPEVK
EEECCCCCCCCHHHH		35.6529996109
443PhosphorylationIPAATDISPEVKEGK
CCCCCCCCHHHHCCC		20.1628889911
466PhosphorylationDNDDIILSSQLQPTA
CCCCEEEECCCCCCC		12.9629996109
472PhosphorylationLSSQLQPTATGSRSS
EECCCCCCCCCCCCC		24.7229996109
474PhosphorylationSQLQPTATGSRSSRL
CCCCCCCCCCCCCCC		37.8628889911
476PhosphorylationLQPTATGSRSSRLSF
CCCCCCCCCCCCCCE		25.3225720772
478PhosphorylationPTATGSRSSRLSFSR
CCCCCCCCCCCCEEC		22.8525720772
479PhosphorylationTATGSRSSRLSFSRH
CCCCCCCCCCCEECC		35.8125720772
482PhosphorylationGSRSSRLSFSRHGHG
CCCCCCCCEECCCCC		21.7729996109
484PhosphorylationRSSRLSFSRHGHGSQ
CCCCCCEECCCCCCC		21.7129996109
490PhosphorylationFSRHGHGSQTSLGSI
EECCCCCCCCCCHHH		25.3028889911
492PhosphorylationRHGHGSQTSLGSIKR
CCCCCCCCCCHHHCH		27.8429996109
493PhosphorylationHGHGSQTSLGSIKRK
CCCCCCCCCHHHCHH		24.0928889911
496PhosphorylationGSQTSLGSIKRKSIM
CCCCCCHHHCHHHHH		30.1729996109
501PhosphorylationLGSIKRKSIMERMGR
CHHHCHHHHHHHHCC		31.0621712547
510PhosphorylationMERMGRPTSPFMGSS
HHHHCCCCCCCCCCC		47.9025720772
511PhosphorylationERMGRPTSPFMGSSF
HHHCCCCCCCCCCCC		20.8725720772
516PhosphorylationPTSPFMGSSFSNMGS
CCCCCCCCCCCCCCC		19.2029996109
517PhosphorylationTSPFMGSSFSNMGSR
CCCCCCCCCCCCCCC		27.2821712547
519PhosphorylationPFMGSSFSNMGSRST
CCCCCCCCCCCCCCC		28.0529996109
523PhosphorylationSSFSNMGSRSTSPTK
CCCCCCCCCCCCCCC		16.5825720772
525PhosphorylationFSNMGSRSTSPTKEG
CCCCCCCCCCCCCCC		34.6325720772
526PhosphorylationSNMGSRSTSPTKEGF
CCCCCCCCCCCCCCC		37.3028889911
527PhosphorylationNMGSRSTSPTKEGFA
CCCCCCCCCCCCCCC		31.6425720772
529PhosphorylationGSRSTSPTKEGFASN
CCCCCCCCCCCCCCC		41.3128889911
535PhosphorylationPTKEGFASNQHATGA
CCCCCCCCCCCCCCC		34.4629996109
540PhosphorylationFASNQHATGASVQSD
CCCCCCCCCCCCCCC		31.0229996109
543PhosphorylationNQHATGASVQSDELE
CCCCCCCCCCCCCCC		23.2629996109
546PhosphorylationATGASVQSDELEDID
CCCCCCCCCCCCCCC		30.7829996109
597PhosphorylationANAMAELSSSMRRRQ
HHHHHHHHHHHHHCC		16.3327738172
605PhosphorylationSSMRRRQSTSVDDEA
HHHHHCCCCCCCCCC		22.3421712547
606PhosphorylationSMRRRQSTSVDDEAP
HHHHCCCCCCCCCCC		25.1629996109
607PhosphorylationMRRRQSTSVDDEAPV
HHHCCCCCCCCCCCC		28.8825720772
615PhosphorylationVDDEAPVSLSKTSSS
CCCCCCCCCCCCCCC		26.3528889911
617PhosphorylationDEAPVSLSKTSSSTR
CCCCCCCCCCCCCCC		26.7828889911
619PhosphorylationAPVSLSKTSSSTRLN
CCCCCCCCCCCCCCC		30.3921712547
620PhosphorylationPVSLSKTSSSTRLNG
CCCCCCCCCCCCCCC		26.4825720772
621PhosphorylationVSLSKTSSSTRLNGL
CCCCCCCCCCCCCCC		40.7425720772
622PhosphorylationSLSKTSSSTRLNGLG
CCCCCCCCCCCCCCC		19.8125720772
630PhosphorylationTRLNGLGYHSRNTSI
CCCCCCCCCCCCCCC		11.1521712547
632PhosphorylationLNGLGYHSRNTSIAS
CCCCCCCCCCCCCCC		20.8128889911
635PhosphorylationLGYHSRNTSIASDID
CCCCCCCCCCCCCCC		22.0221712547
636PhosphorylationGYHSRNTSIASDIDG
CCCCCCCCCCCCCCC		21.5028889911
639PhosphorylationSRNTSIASDIDGVPK
CCCCCCCCCCCCCCC		33.1728889911
658PhosphorylationGAPPAAHTSAQMQRM
CCCCCCCCHHHHHHH		22.4924763107
666PhosphorylationSAQMQRMSNSFASQT
HHHHHHHHHHHHHHH		31.3521712547
668PhosphorylationQMQRMSNSFASQTKQ
HHHHHHHHHHHHHHH		18.1925720772
671PhosphorylationRMSNSFASQTKQVFG
HHHHHHHHHHHHHHC		36.0525720772
695PhosphorylationESLRHSRSNMSRSPS
HHHHHHHHHCCCCCC		39.6425720772
698PhosphorylationRHSRSNMSRSPSPML
HHHHHHCCCCCCHHH		33.5825720772
700PhosphorylationSRSNMSRSPSPMLSR
HHHHCCCCCCHHHCC		23.5628889911
702PhosphorylationSNMSRSPSPMLSRRS
HHCCCCCCHHHCCCC		24.9628889911
709PhosphorylationSPMLSRRSSTLRPSF
CHHHCCCCCCCCCCH		26.9429996109
710PhosphorylationPMLSRRSSTLRPSFE
HHHCCCCCCCCCCHH		29.6529996109
711PhosphorylationMLSRRSSTLRPSFER
HHCCCCCCCCCCHHH		28.2125720772
715PhosphorylationRSSTLRPSFERSASS
CCCCCCCCHHHCCCC		33.0529996109
719PhosphorylationLRPSFERSASSLSVR
CCCCHHHCCCCCEEE		25.8825720772
721PhosphorylationPSFERSASSLSVRQS
CCHHHCCCCCEEEHH		32.8129996109
722PhosphorylationSFERSASSLSVRQSD
CHHHCCCCCEEEHHH		25.1229996109
724PhosphorylationERSASSLSVRQSDVV
HHCCCCCEEEHHHCC		19.7329996109
728PhosphorylationSSLSVRQSDVVSPAP
CCCEEEHHHCCCCCC		23.0829996109
732PhosphorylationVRQSDVVSPAPSTRA
EEHHHCCCCCCCCCC		18.3928889911
736PhosphorylationDVVSPAPSTRARGQS
HCCCCCCCCCCCCCC		32.4125720772
737PhosphorylationVVSPAPSTRARGQSV
CCCCCCCCCCCCCCC		27.5629996109
743PhosphorylationSTRARGQSVSGQQRP
CCCCCCCCCCCCCCC		22.5228889911
745PhosphorylationRARGQSVSGQQRPSS
CCCCCCCCCCCCCCC		35.8129996109
751PhosphorylationVSGQQRPSSSMSLYG
CCCCCCCCCCCHHHC		36.9128889911
752PhosphorylationSGQQRPSSSMSLYGE
CCCCCCCCCCHHHCC		32.5129996109
753PhosphorylationGQQRPSSSMSLYGEY
CCCCCCCCCHHHCCC		19.4125720772
755PhosphorylationQRPSSSMSLYGEYNK
CCCCCCCHHHCCCCC		22.0125720772
757PhosphorylationPSSSMSLYGEYNKSQ
CCCCCHHHCCCCCCC		10.7025720772
763PhosphorylationLYGEYNKSQPQLSMQ
HHCCCCCCCCCHHCC		43.3828889911
768PhosphorylationNKSQPQLSMQRSVSP
CCCCCCHHCCCCCCC		13.9721712547
772PhosphorylationPQLSMQRSVSPNPLG
CCHHCCCCCCCCCCC		15.2825720772
774PhosphorylationLSMQRSVSPNPLGPN
HHCCCCCCCCCCCCC		21.8728889911
784PhosphorylationPLGPNRRSSSVLQSQ
CCCCCCCCHHHHHHC		24.5925720772
785PhosphorylationLGPNRRSSSVLQSQK
CCCCCCCHHHHHHCC		23.7429996109
786PhosphorylationGPNRRSSSVLQSQKS
CCCCCCHHHHHHCCC		28.2625720772
806PhosphorylationSNRNNGGYSGSRPSS
CCCCCCCCCCCCCCC		15.9729996109
807PhosphorylationNRNNGGYSGSRPSSE
CCCCCCCCCCCCCCH		33.3028889911
809PhosphorylationNNGGYSGSRPSSEMG
CCCCCCCCCCCCHHH		34.7729996109
812PhosphorylationGYSGSRPSSEMGHRY
CCCCCCCCCHHHHCC		37.5128889911
813PhosphorylationYSGSRPSSEMGHRYG
CCCCCCCCHHHHCCC		33.9928889911
821PhosphorylationEMGHRYGSMSGRSMR
HHHHCCCCCCCHHHH		10.8027738172
823PhosphorylationGHRYGSMSGRSMRQV
HHCCCCCCCHHHHHH		32.5227738172
836PhosphorylationQVSQRSTSRARSPEP
HHHHHHCCCCCCCCC		25.7825720772
840PhosphorylationRSTSRARSPEPTNRN
HHCCCCCCCCCCCCC		32.4129996109
844PhosphorylationRARSPEPTNRNSVQS
CCCCCCCCCCCCCCC		45.1929996109
848PhosphorylationPEPTNRNSVQSKNVD
CCCCCCCCCCCCCCC		20.4929996109
851PhosphorylationTNRNSVQSKNVDPRA
CCCCCCCCCCCCCCC		24.8425720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CDC15_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CDC15_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CDC15_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC16_SCHPOcdc16genetic
16687577
IMP2_SCHPOimp2genetic
9786952
CDC12_SCHPOcdc12genetic
12939254
MYO1_SCHPOmyo1physical
12939254
CDC12_SCHPOcdc12physical
12939254
ETD1_SCHPOetd1physical
15933715
CDC16_SCHPOcdc16genetic
1527180
CDC12_SCHPOcdc12physical
20603077
CYK3_SCHPOcyk3physical
20603077
RNG2_SCHPOrng2physical
20603077
RAD24_SCHPOrad24physical
20603077
IMP2_SCHPOimp2genetic
20603077
MYO2_SCHPOmyo2genetic
20603077
AIN1_SCHPOain1genetic
20603077
MLR4_SCHPOcdc4genetic
20603077
RNG2_SCHPOrng2genetic
20603077
SID2_SCHPOsid2genetic
20603077
CDC12_SCHPOcdc12genetic
20603077
MID1_SCHPOmid1genetic
20603077
SID4_SCHPOsid4genetic
20603077
FLP1_SCHPOclp1genetic
20603077
CDC16_SCHPOcdc16genetic
20805322
MID1_SCHPOmid1physical
21422229
CDC15_SCHPOcdc15physical
21422229
MLR4_SCHPOcdc4genetic
19139265
FLP1_SCHPOclp1genetic
19139265
IMP2_SCHPOimp2genetic
19139265
MYO2_SCHPOmyo2genetic
19139265
MYO3_SCHPOmyp2genetic
19139265
PP2B_SCHPOppb1genetic
19139265
RNG2_SCHPOrng2genetic
19139265
SID2_SCHPOsid2genetic
19139265
SID4_SCHPOsid4genetic
19139265
CDC12_SCHPOcdc12genetic
19139265
AIN1_SCHPOain1genetic
19139265
MID1_SCHPOmid1genetic
19139265
MLR1_SCHPOrlc1genetic
19139265
INN1_SCHPOfic1physical
19139265
YOCC_SCHPOpxl1physical
19139265
MYO1_SCHPOmyo1genetic
21885283
SET3_SCHPOset3genetic
22347452
YDBJ_SCHPOsnt1genetic
22347452
HIF2_SCHPOhif2genetic
22347452
MID1_SCHPOmid1physical
22427686
PLO1_SCHPOplo1genetic
10924454
CDC7_SCHPOcdc7genetic
10924454
SPG1_SCHPOspg1genetic
10924454
INN1_SCHPOfic1physical
23093943
CHR4_SCHPOchr4physical
22905165
ATP10_SCHPOatp10genetic
22681890
YDEA_SCHPOnod1physical
23966468
CDC15_SCHPOcdc15physical
26702831
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CDC15_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-331; SER-332; THR-529;SER-636; SER-639; SER-700 AND SER-774, AND MASS SPECTROMETRY.

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