CHR4_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHR4_SCHPO
• UniProt AC: O94614
• Protein Name: Chitin synthase regulatory factor 4
• Gene Name: chr4
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 633
• Subcellular Localization: Cytoplasm . Localizes to the cell tips and septum during vegetative growth.
• Protein Description: Involved in septum formation. Required for the proper localization of chs2 at the septum..
• Protein Sequence: MDSASSMRNRSPLGVPEFSYSSQSVNNIRGIKSRNRSSIGHSITDPQVASRINAFYLSNVQSSIPFETDAIGPAYGIGDMIAPEMNDTQSLSASVTNMKKENFYSRPNVSSSSILLTIKRATSSQETKRDRPLPNIRNSAPSATRSHSTPCVAPGYLRTSNEAADVVFPHEEAHFSNHNPKPNNGSPLQKQVVADLPFPLPVSDEEQLDWIRANEDLVHSQDIDEALEWAEYVLRFTQSHLPYLQTYESENLHEINYLESMCENALYKIREFSELENAKAMYFDAYVYETGAFDVESDIQRAWDLYSSSANLGYTRSLYRLGVLLEDQGNLEEAVEYFEKGVSENDSACCWRLSLLILEGMLDGVGEYAHRHASGLELLERSADTADADVPSGLYSHALVNLHEHPGLVDLGSENIRVPIDEATALKSFAKAAFLGHSSAQLRMGAVYEFGKYGCPVVPRYSLFYYSAAAKRGETEADLAVAKWYLNGSDGIPVDEDLAFMHAERASMAGNANAQFLMGYLFDTRGNTEQATYWYNEAAKAGHSEAIERLALLENQIQEPEPENITSSQYPNQDVIKEIPVTASETSPPHAPAVSSTPVTSAPPVSQTKVTKVSVPKKTSKKFLIKHNKCIIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSASSMRNR -----CCCHHHHCCC	28.84	21712547
5	Phosphorylation	---MDSASSMRNRSP ---CCCHHHHCCCCC	28.72	21712547
11	Phosphorylation	ASSMRNRSPLGVPEF HHHHCCCCCCCCCCC	28.20	29996109
19	Phosphorylation	PLGVPEFSYSSQSVN CCCCCCCCCCCCCHH	23.57	21712547
20	Phosphorylation	LGVPEFSYSSQSVNN CCCCCCCCCCCCHHC	20.05	21712547
21	Phosphorylation	GVPEFSYSSQSVNNI CCCCCCCCCCCHHCC	22.24	29996109
22	Phosphorylation	VPEFSYSSQSVNNIR CCCCCCCCCCHHCCC	20.45	25720772
24	Phosphorylation	EFSYSSQSVNNIRGI CCCCCCCCHHCCCCC	28.85	25720772
37	Phosphorylation	GIKSRNRSSIGHSIT CCCCCCCCCCCCCCC	29.83	29996109
38	Phosphorylation	IKSRNRSSIGHSITD CCCCCCCCCCCCCCC	29.38	29996109
42	Phosphorylation	NRSSIGHSITDPQVA CCCCCCCCCCCHHHH	23.21	29996109
44	Phosphorylation	SSIGHSITDPQVASR CCCCCCCCCHHHHHH	44.64	29996109
104	Phosphorylation	NMKKENFYSRPNVSS HHCCCCCCCCCCCCH	18.49	25720772
105	Phosphorylation	MKKENFYSRPNVSSS HCCCCCCCCCCCCHH	36.80	21712547
110	Phosphorylation	FYSRPNVSSSSILLT CCCCCCCCHHHEEEE	31.01	29996109
111	Phosphorylation	YSRPNVSSSSILLTI CCCCCCCHHHEEEEE	24.67	24763107
112	Phosphorylation	SRPNVSSSSILLTIK CCCCCCHHHEEEEEE	17.56	24763107
113	Phosphorylation	RPNVSSSSILLTIKR CCCCCHHHEEEEEEH	21.14	24763107
117	Phosphorylation	SSSSILLTIKRATSS CHHHEEEEEEHHCCC	22.47	21712547
122	Phosphorylation	LLTIKRATSSQETKR EEEEEHHCCCCCCCC	32.70	21712547
123	Phosphorylation	LTIKRATSSQETKRD EEEEHHCCCCCCCCC	29.10	21712547
124	Phosphorylation	TIKRATSSQETKRDR EEEHHCCCCCCCCCC	27.90	25720772
127	Phosphorylation	RATSSQETKRDRPLP HHCCCCCCCCCCCCC	24.60	21712547
139	Phosphorylation	PLPNIRNSAPSATRS CCCCCCCCCCCCCCC	31.54	29996109
146	Phosphorylation	SAPSATRSHSTPCVA CCCCCCCCCCCCCCC	19.89	29996109
148	Phosphorylation	PSATRSHSTPCVAPG CCCCCCCCCCCCCCC	34.98	28889911
149	Phosphorylation	SATRSHSTPCVAPGY CCCCCCCCCCCCCCE	18.45	25720772
374	Phosphorylation	EYAHRHASGLELLER HHHHHHHHHHHHHHH	37.47	25720772
584	Phosphorylation	KEIPVTASETSPPHA CCCCCCCCCCCCCCC	31.85	29996109
586	Phosphorylation	IPVTASETSPPHAPA CCCCCCCCCCCCCCC	44.00	27738172
587	Phosphorylation	PVTASETSPPHAPAV CCCCCCCCCCCCCCC	32.17	27738172
597	Phosphorylation	HAPAVSSTPVTSAPP CCCCCCCCCCCCCCC	17.80	27738172
600	Phosphorylation	AVSSTPVTSAPPVSQ CCCCCCCCCCCCCCC	22.00	29996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHR4_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHR4_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHR4_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACT_SCHPO	act1	genetic	22905165
CDC15_SCHPO	cdc15	genetic	22905165
IMP2_SCHPO	imp2	genetic	22905165

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-148, AND MASSSPECTROMETRY.
PubMed: 18257517