CYK3_SCHPO - dbPTM
CYK3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CYK3_SCHPO
UniProt AC O14302
Protein Name cytokinesis protein 3
Gene Name cyk3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 886
Subcellular Localization Cell tip . Cell septum .
Protein Description Involved in cytokinesis..
Protein Sequence MSIPKQLPCMVRALYAWPGEREGDLKFTEGDLIECLSIGDGKWWIGRHINTNTQGIFPSNFVHCLDIPTVRPGSSMSRTSASSFRYSSPQKSSIDTPITSSDQGLTPDLVGSSNALNKPTRESDSLKHQKSHPMLNSLGSSLSLKKSVSRPPSSMSRTNLDVSSRWDNTADNDSQIDAQDLSRSTPSPLRSAMENVLQSLNAMGKKSFSRANSPLLRLTKSTTTSKETDFIPVPPAHGSTSMTSRSKLDDSTDNSSKPRTSLQPGESPMKSSRDISRKPSMASSVLSPSDYFPQHRRFQSAPAPIPRPVSTLIPLTQVRTTASNVIKPRPQTTERPSTAQSFRKGGGFLKKTFKKLLRRGSSKRKPSLQPTPPVSYPAHNVPQKGVRPASPHTLKSVKDDLKRTKTYTKAEFAAKREEIFNKLSMPVYEPLKDLSECIGNVLADGEPVQFSVGTNIHNMNFSAIDKQIRSIIPQRVQVSPAVLAKNYLAPGQTTALAQMRAVFIYISERITFTNQTLDNDELRTSTQVISEGQGTPFEVALLVKEMLQALDLWCEVIEGYLKSPDDIYYTRDININHAWNVVTFDNEVRLIDASFASPTHPQQALKSSSSNDFYFLMKPNECIFTHVPENPDQQFIMPDLSMPIVMALPWVSSVYFTLGLKLRKFNTSILHLNDLEVLQIEFLAPKDIECVAEVDALSALAPTADVSQCYKYTLTQAFWETPDIRVMRVKAVMPANNRAAVLRIYAGRLGVSSPVRTAPHPMAMSLPFVHHGKNKALEFVTRHPVPHCPSVDLYINSPQCGTLHSGVEYKFNVSAYACQPSTSISNTRLAIQTPTGNIVRLREERSGNGVIFFSLSLTINETGEYRALILAEKIGRWVVYATWQAV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationNTQGIFPSNFVHCLD
CCCCCCCCCCEEEEE		31.9529996109
69PhosphorylationVHCLDIPTVRPGSSM
EEEEECCCCCCCCCC		29.4929996109
74PhosphorylationIPTVRPGSSMSRTSA
CCCCCCCCCCCCCCC		26.0829996109
75PhosphorylationPTVRPGSSMSRTSAS
CCCCCCCCCCCCCCC		27.0529996109
77PhosphorylationVRPGSSMSRTSASSF
CCCCCCCCCCCCCCC		34.0629996109
79PhosphorylationPGSSMSRTSASSFRY
CCCCCCCCCCCCCCC		22.7225720772
80PhosphorylationGSSMSRTSASSFRYS
CCCCCCCCCCCCCCC		25.6625720772
82PhosphorylationSMSRTSASSFRYSSP
CCCCCCCCCCCCCCC		29.7625720772
83PhosphorylationMSRTSASSFRYSSPQ
CCCCCCCCCCCCCCC		17.2925720772
93PhosphorylationYSSPQKSSIDTPITS
CCCCCCCCCCCCCCC		31.3629996109
101PhosphorylationIDTPITSSDQGLTPD
CCCCCCCCCCCCCHH		25.8829996109
106PhosphorylationTSSDQGLTPDLVGSS
CCCCCCCCHHHCCCC		22.9125720772
112PhosphorylationLTPDLVGSSNALNKP
CCHHHCCCCCCCCCC		16.9721712547
113PhosphorylationTPDLVGSSNALNKPT
CHHHCCCCCCCCCCC		21.8629996109
120PhosphorylationSNALNKPTRESDSLK
CCCCCCCCCCCHHHC		48.9921712547
123PhosphorylationLNKPTRESDSLKHQK
CCCCCCCCHHHCCHH		29.2521712547
125PhosphorylationKPTRESDSLKHQKSH
CCCCCCHHHCCHHCC		48.9021712547
131PhosphorylationDSLKHQKSHPMLNSL
HHHCCHHCCHHHHHH		26.6721712547
137PhosphorylationKSHPMLNSLGSSLSL
HCCHHHHHHHHHHHH		30.1029996109
140PhosphorylationPMLNSLGSSLSLKKS
HHHHHHHHHHHHHCC		33.1421712547
141PhosphorylationMLNSLGSSLSLKKSV
HHHHHHHHHHHHCCC		21.8525720772
143PhosphorylationNSLGSSLSLKKSVSR
HHHHHHHHHHCCCCC		39.8424763107
147PhosphorylationSSLSLKKSVSRPPSS
HHHHHHCCCCCCCCC		24.6029996109
149PhosphorylationLSLKKSVSRPPSSMS
HHHHCCCCCCCCCCC		46.2729996109
153PhosphorylationKSVSRPPSSMSRTNL
CCCCCCCCCCCCCCC		41.1629996109
154PhosphorylationSVSRPPSSMSRTNLD
CCCCCCCCCCCCCCC		26.9325720772
156PhosphorylationSRPPSSMSRTNLDVS
CCCCCCCCCCCCCHH		37.5925720772
158PhosphorylationPPSSMSRTNLDVSSR
CCCCCCCCCCCHHHC		32.5925720772
163PhosphorylationSRTNLDVSSRWDNTA
CCCCCCHHHCCCCCC		17.5329996109
169PhosphorylationVSSRWDNTADNDSQI
HHHCCCCCCCCCCCC		32.6829996109
174PhosphorylationDNTADNDSQIDAQDL
CCCCCCCCCCCHHHH		34.9829996109
182PhosphorylationQIDAQDLSRSTPSPL
CCCHHHHHCCCCHHH		32.2625720772
184PhosphorylationDAQDLSRSTPSPLRS
CHHHHHCCCCHHHHH		41.0929996109
185PhosphorylationAQDLSRSTPSPLRSA
HHHHHCCCCHHHHHH		27.0325720772
187PhosphorylationDLSRSTPSPLRSAME
HHHCCCCHHHHHHHH		36.3329996109
191PhosphorylationSTPSPLRSAMENVLQ
CCCHHHHHHHHHHHH		39.3825720772
199PhosphorylationAMENVLQSLNAMGKK
HHHHHHHHHHHHCCH		21.3029996109
207PhosphorylationLNAMGKKSFSRANSP
HHHHCCHHHHCCCCC		31.7521712547
209PhosphorylationAMGKKSFSRANSPLL
HHCCHHHHCCCCCCE		37.2624763107
213PhosphorylationKSFSRANSPLLRLTK
HHHHCCCCCCEEEEC		18.8828889911
219PhosphorylationNSPLLRLTKSTTTSK
CCCCEEEECCCCCCC		19.2621712547
239PhosphorylationPVPPAHGSTSMTSRS
ECCCCCCCCCCCCHH		13.8721712547
243PhosphorylationAHGSTSMTSRSKLDD
CCCCCCCCCHHHCCC		22.2821712547
244PhosphorylationHGSTSMTSRSKLDDS
CCCCCCCCHHHCCCC		26.3929996109
246PhosphorylationSTSMTSRSKLDDSTD
CCCCCCHHHCCCCCC		37.0229996109
252PhosphorylationRSKLDDSTDNSSKPR
HHHCCCCCCCCCCCC		46.3121712547
256PhosphorylationDDSTDNSSKPRTSLQ
CCCCCCCCCCCCCCC		53.5921712547
260PhosphorylationDNSSKPRTSLQPGES
CCCCCCCCCCCCCCC		42.1721712547
261PhosphorylationNSSKPRTSLQPGESP
CCCCCCCCCCCCCCC		26.7024763107
267PhosphorylationTSLQPGESPMKSSRD
CCCCCCCCCCCCCCC		35.8924763107
271PhosphorylationPGESPMKSSRDISRK
CCCCCCCCCCCCCCC		25.1025720772
272PhosphorylationGESPMKSSRDISRKP
CCCCCCCCCCCCCCC		28.5825720772
276PhosphorylationMKSSRDISRKPSMAS
CCCCCCCCCCCCHHH		38.2425720772
280PhosphorylationRDISRKPSMASSVLS
CCCCCCCCHHHHCCC		29.9829996109
283PhosphorylationSRKPSMASSVLSPSD
CCCCCHHHHCCCHHH		16.6129996109
284PhosphorylationRKPSMASSVLSPSDY
CCCCHHHHCCCHHHC		19.9625720772
287PhosphorylationSMASSVLSPSDYFPQ
CHHHHCCCHHHCCCC		21.8729996109
300PhosphorylationPQHRRFQSAPAPIPR
CCCCCCCCCCCCCCC		33.2429996109
310PhosphorylationAPIPRPVSTLIPLTQ
CCCCCCCCCCEEEEE		21.8525720772
311PhosphorylationPIPRPVSTLIPLTQV
CCCCCCCCCEEEEEE		29.0129996109
320PhosphorylationIPLTQVRTTASNVIK
EEEEEEEECCCCCCC		28.0525720772
321PhosphorylationPLTQVRTTASNVIKP
EEEEEEECCCCCCCC		19.9529996109
323PhosphorylationTQVRTTASNVIKPRP
EEEEECCCCCCCCCC		29.5429996109
332PhosphorylationVIKPRPQTTERPSTA
CCCCCCCCCCCCCHH		33.0524763107
333PhosphorylationIKPRPQTTERPSTAQ
CCCCCCCCCCCCHHH		25.4229996109
337PhosphorylationPQTTERPSTAQSFRK
CCCCCCCCHHHHHHH		42.4725720772
338PhosphorylationQTTERPSTAQSFRKG
CCCCCCCHHHHHHHC		31.2525720772
341PhosphorylationERPSTAQSFRKGGGF
CCCCHHHHHHHCCCH		25.2624763107
390PhosphorylationQKGVRPASPHTLKSV
CCCCCCCCCCCHHHH		21.6428889911
393PhosphorylationVRPASPHTLKSVKDD
CCCCCCCCHHHHHHH		38.9921712547
406PhosphorylationDDLKRTKTYTKAEFA
HHHHHCCCCCHHHHH		35.4925720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CYK3_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CYK3_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CYK3_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC15_SCHPOcdc15physical
20603077
COPG_SCHPOsec21physical
20603077
RAD24_SCHPOrad24physical
20603077
RAD25_SCHPOrad25physical
20603077
ACON_SCHPOSPAC24C9.06cphysical
20603077
EIF3M_SCHPOSPAC1751.03physical
20603077
PAN1_SCHPOpan1physical
20603077
EIF3H_SCHPOSPAC821.05physical
20603077
GLYM_SCHPOshm2physical
20603077
NOG1_SCHPOnog1physical
20603077
AP1B1_SCHPOapl2physical
20603077
MYO1_SCHPOmyo1physical
20603077
RS26B_SCHPOrps2602physical
20603077
US107_SCHPOusp107physical
20603077
MUG64_SCHPOmug64physical
20603077
CCR4_SCHPOccr4physical
20603077
GPD1_SCHPOgpd1physical
20603077
SYA_SCHPOala1physical
20603077
MS116_SCHPOSPBC691.04physical
20603077
RIR1_SCHPOcdc22physical
20603077
YFHH_SCHPOSPAC23A1.17physical
20603077
SYNC_SCHPOnrs1physical
20603077
NOG2_SCHPOSPAC6F6.03cphysical
20603077
MLR4_SCHPOcdc4genetic
22573890
MYO2_SCHPOmyo2genetic
22573890
CHS2_SCHPOchs2genetic
22573890
CDC12_SCHPOcdc12genetic
22573890
CDC15_SCHPOcdc15genetic
22573890
INN1_SCHPOfic1physical
23093943
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CYK3_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-213, AND MASSSPECTROMETRY.

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