PAN1_SCHPO - dbPTM
PAN1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PAN1_SCHPO
UniProt AC Q10172
Protein Name Actin cytoskeleton-regulatory complex protein pan1
Gene Name pan1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1794
Subcellular Localization Cell membrane
Peripheral membrane protein
Cytoplasmic side. Endosome membrane
Peripheral membrane protein
Cytoplasmic side. Cytoplasm, cytoskeleton, actin patch. Cytoplasmic and cortical actin patches..
Protein Description Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)..
Protein Sequence MSYPNQMNGSMYGYGANNGVQPGFDSYGMPINQGGMNYQQQTYPYQQPYQPDGYAGNTMLPFQQSQPATQFNNGFGYASQPTGSVADYGQQQQQMYGYNGMMPQTMNNTGFMQPQQTGAIPGFAPQPTGFVQPQPTGFMSQQPASFMQPQRTGGAGFIQPQRTGAMPAYQPQMNNFMQPQKTGGFAPQATGFMQTQPFGAAPSFAPQPTGFVQPQQTGVVMPPQPTGYLQAQPTGPFASFVQPQQTASFMPAAQPLKPQKTGQIHNSKAMDTRLSFVSAADQAKFEQLFKSAVGREEAMSSEIGKAILVRSKLPTVQLSKIWRLSDTTRSGRLLFPQFVLAMYLCNLGLTGKPIPDKVPDGILNEVNAMVDAISFSLDENYAKPTQPIPQAAAQQMAAQMFGGFQQAAGIPSQITGFQPQAMMPQRTGMQPQMTGFQQPMIPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPQMTGFQQPMMPQRTGLQPQMTGFQQPMVPQRTGMQPMMPGLQQPMAPQRTGMQPMMPQRTGMQPQMTGFQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMMPQRTGMQPQMPGMQQPMAPQRTGMQPMAPQRTGMQPQMTGGPMLPQRTGGMAPQPTGMPGQWGFINTPLSNLPGIEALGQQMMPNAPSGGLNNTFQQKKDIPWAISKEEKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSLDRDEFAVALHLIYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTSNRKPFGAENQSKLKKNSFYDNPSETTEKDATLYRHNDSDASAYVSSARRRDFKEEKIESAPPIINDIDSEIASLKKRIHEKSLVVNALEDKKLAATPANDVQNDSLIYRIKSVQDEINRLSTSNKSPEVASMNVRLEELSTRVSKMLSDINEVDHTIASLSLKLFQAEDTKNSYDQTSPEATQERNRTISSKLAEMEKQKNESKAALEQMKNYVTNIENNIRAKLLPSAANDDAWLSQNVVDESVTRVVKELPVPAPAAPQTLNPPSVSTVQQSKPIESNTHTPEVKATSESPSASSNLEDRAARIKAEAQRRMNERLAALGIKPRQKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPAVSASISTPPAVVPTVQHPQPTKQIPTAAVKDPSTTSTSFNTAPIPQQAPLENQFSKMSLEPPVRPAVPTSPKPQIPDSSNVHAPPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIEDETSTMPLKASQPTNPGAPSNHAPQVVPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAPPAPVSQLPPAVPNVPVPSMIPSVAQQPPSSVAPATAPSSTLPPSQSSFAHVPSPAPPAPQHPSAAALSSAPADNSMPHRSSPYAPQEPVQKPQAINNIAPATNLGTSQSFSPRMGPVNNSGSPLAMNAAGQPSLAVPAVPSAPSNHFNPFAKMQPPAPSPLQPSGHDSDNWSQHGDEEEEDSEDDIRSSKDAAALAAKLFGGMAPAHPVSTPPVRPQSAAPPQMSAPTPPPPPMSVPPPPSAPPMPAGPPSAPPPPLPASSAPSVPNPGDRSALLQQIHTGTRLKKTVTTDKSKPIAGRVLDASDGNSSAWYGNLS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
152PhosphorylationSFMQPQRTGGAGFIQ
CCCCCCCCCCCCCCC		34.4228889911
163PhosphorylationGFIQPQRTGAMPAYQ
CCCCCCCCCCCCCCC		24.8429996109
261PhosphorylationQPLKPQKTGQIHNSK
CCCCCCCCCCCCCCC		29.1324763107
311PhosphorylationGKAILVRSKLPTVQL
HHHHHHHCCCCCEEH		30.9425720772
427PhosphorylationQAMMPQRTGMQPQMT
CCCCCCCCCCCCCCC		31.5825720772
434PhosphorylationTGMQPQMTGFQQPMI
CCCCCCCCCCCCCCC		29.6029996109
445PhosphorylationQPMIPQRTGMQPQMT
CCCCCCCCCCCCCCC		31.5829996109
452PhosphorylationTGMQPQMTGFQQPMM
CCCCCCCCCCCCCCC		29.6029996109
463PhosphorylationQPMMPQRTGLQPQMT
CCCCCCCCCCCCCCC		36.6829996109
470PhosphorylationTGLQPQMTGFQQPMV
CCCCCCCCCCCCCCC		29.6029996109
481PhosphorylationQPMVPQRTGMQPQMT
CCCCCCCCCCCCCCC		31.5827738172
499PhosphorylationQPMMPQRTGLQPQMT
CCCCCCCCCCCCCCC		36.6829996109
506PhosphorylationTGLQPQMTGFQQPMV
CCCCCCCCCCCCCCC		29.6029996109
517PhosphorylationQPMVPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5829996109
535PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
545PhosphorylationQPMMPQRTGMQPQMT
CCCCCCCCCCCCCCC		31.5829996109
552PhosphorylationTGMQPQMTGFQQPMA
CCCCCCCCCCCCCCC		29.6029996109
563PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
573PhosphorylationQPMMPQRTGMQPQMP
CCCCCCCCCCCCCCC		31.5829996109
591PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
601PhosphorylationQPMMPQRTGMQQPMA
CCCCCCCCCCCCCCC		31.5825720772
612PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
622PhosphorylationQPMMPQRTGMQPQMP
CCCCCCCCCCCCCCC		31.5829996109
640PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
650PhosphorylationQPMMPQRTGMQPQMP
CCCCCCCCCCCCCCC		31.5829996109
668PhosphorylationQPMAPQRTGMQPMAP
CCCCCCCCCCCCCCC		31.5825720772
678PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
688PhosphorylationQPMMPQRTGMQPQMP
CCCCCCCCCCCCCCC		31.5829996109
706PhosphorylationQPMAPQRTGMQPMMP
CCCCCCCCCCCCCCC		31.5828889911
716PhosphorylationQPMMPQRTGMQPQMP
CCCCCCCCCCCCCCC		31.5829996109
734PhosphorylationQPMAPQRTGMQPMAP
CCCCCCCCCCCCCCC		31.5825720772
744PhosphorylationQPMAPQRTGMQPQMT
CCCCCCCCCCCCCCC		31.5829996109
751PhosphorylationTGMQPQMTGGPMLPQ
CCCCCCCCCCCCCCC		33.4729996109
914PhosphorylationSTRNFTESLNQVKNL
CCCCHHHHHHHHHHH		29.5725720772
926PhosphorylationKNLIKNDTSNRKPFG
HHHHHCCCCCCCCCC		36.9824763107
944PhosphorylationQSKLKKNSFYDNPSE
HHHHCCCCCCCCCCC		33.7824763107
1023PhosphorylationEDKKLAATPANDVQN
CCCCCCCCCCCCCCC		19.8224763107
1039PhosphorylationSLIYRIKSVQDEINR
HHHHHHHHHHHHHHH		23.7324763107
1049PhosphorylationDEINRLSTSNKSPEV
HHHHHHHCCCCCHHH		40.6929996109
1050PhosphorylationEINRLSTSNKSPEVA
HHHHHHCCCCCHHHH		38.5929996109
1053PhosphorylationRLSTSNKSPEVASMN
HHHCCCCCHHHHHHH		30.4625720772
1101PhosphorylationAEDTKNSYDQTSPEA
HHHHCCCCCCCCHHH		22.8229996109
1104PhosphorylationTKNSYDQTSPEATQE
HCCCCCCCCHHHHHH		43.2721712547
1105PhosphorylationKNSYDQTSPEATQER
CCCCCCCCHHHHHHH		18.3425720772
1206PhosphorylationQQSKPIESNTHTPEV
CCCCCCCCCCCCCCC		47.9921712547
1210PhosphorylationPIESNTHTPEVKATS
CCCCCCCCCCCEEEC		21.0721712547
1216PhosphorylationHTPEVKATSESPSAS
CCCCCEEECCCCCCC		27.5821712547
1217PhosphorylationTPEVKATSESPSASS
CCCCEEECCCCCCCC		40.7221712547
1219PhosphorylationEVKATSESPSASSNL
CCEEECCCCCCCCCH		24.7528889911
1221PhosphorylationKATSESPSASSNLED
EEECCCCCCCCCHHH		50.4928889911
1224PhosphorylationSESPSASSNLEDRAA
CCCCCCCCCHHHHHH		45.1921712547
1259PhosphorylationPRQKGTPSPAPVNSA
CCCCCCCCCCCCCCC		33.2728889911
1301PhosphorylationAVSASISTPPAVVPT
CEEEECCCCCCCCCC		31.4627738172
1372PhosphorylationPKPQIPDSSNVHAPP
CCCCCCCCCCCCCCC		20.6127738172
1406PhosphorylationSAPERRDSFGSVSSG
CCCCHHHCCCCCCCC		29.6928889911
1409PhosphorylationERRDSFGSVSSGSNV
CHHHCCCCCCCCCCC		19.4728889911
1411PhosphorylationRDSFGSVSSGSNVSS
HHCCCCCCCCCCCCC		30.5825720772
1412PhosphorylationDSFGSVSSGSNVSSI
HCCCCCCCCCCCCCC		44.0528889911
1414PhosphorylationFGSVSSGSNVSSIED
CCCCCCCCCCCCCCC		35.6928889911
1417PhosphorylationVSSGSNVSSIEDETS
CCCCCCCCCCCCCCC		29.8328889911
1580PhosphorylationINNIAPATNLGTSQS
HHCCCCCCCCCCCCC		29.8929996109
1585PhosphorylationPATNLGTSQSFSPRM
CCCCCCCCCCCCCCC		23.2527738172
1587PhosphorylationTNLGTSQSFSPRMGP
CCCCCCCCCCCCCCC		27.7129996109
1589PhosphorylationLGTSQSFSPRMGPVN
CCCCCCCCCCCCCCC		19.4929996109
1598PhosphorylationRMGPVNNSGSPLAMN
CCCCCCCCCCCCCCC		35.1329996109
1600PhosphorylationGPVNNSGSPLAMNAA
CCCCCCCCCCCCCCC		19.3029996109
1637PhosphorylationKMQPPAPSPLQPSGH
CCCCCCCCCCCCCCC		40.1127738172
1646PhosphorylationLQPSGHDSDNWSQHG
CCCCCCCCCCHHHCC		27.4621712547
1650PhosphorylationGHDSDNWSQHGDEEE
CCCCCCHHHCCCCCC		20.6727738172
1660PhosphorylationGDEEEEDSEDDIRSS
CCCCCCCCHHHHHHH		46.3221712547
1750PhosphorylationVPNPGDRSALLQQIH
CCCCCCHHHHHHHHH		28.1929996109
1758PhosphorylationALLQQIHTGTRLKKT
HHHHHHHHCCCCEEE		41.7129996109
1760PhosphorylationLQQIHTGTRLKKTVT
HHHHHHCCCCEEEEC		33.7029996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PAN1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PAN1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PAN1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SLA2_SCHPOend4genetic
23727096
PAN1_SCHPOpan1physical
26771498
FFT2_SCHPOfft2physical
26771498
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PAN1_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-152; THR-706; SER-1219;SER-1221; SER-1406; SER-1409; SER-1412 AND SER-1414, AND MASSSPECTROMETRY.

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