| UniProt ID | CCR4_SCHPO | |
|---|---|---|
| UniProt AC | O74874 | |
| Protein Name | Glucose-repressible alcohol dehydrogenase transcriptional effector | |
| Gene Name | ccr4 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 690 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity).. | |
| Protein Sequence | MFNPRYTQGTIYPGAHPGLLTPDHQHAAILSVQNSPALENSNISEHWKQQIALATQSRSFSSPHQRAHNAAALARSGGPGFSMNYNARTGAFTGGPNAAGLSSLGGKYNTSSTTTTLTTSTTLNTSSGTTLNSTSKTTTSSVAVDDQKSKSDSKKERRDWTCLDLGGIGLRNVSTDLFKFSFLTELYINHNNLTRLPPEIGKLKNLVILDASGNSIKTIPPELGLLTELREVLLFDNMISVIPAELGTLFQLKILGIEGNPLQDVYKNQIMESGTAGLIAALRDGCPVGPPPPERGWEKLVSDDDDDVNDNVSTSVRDLTAADSNKPSTTSKNLKFTIMSYNVLCERYATSTLYGYTPSWALSWSYRKDLIMQELGGYNADIICLQEVDVENYDTFFAPQMSLKGYKGVHFPKSRVRTMNEVERRIVDGCATFFKTSKYVMHEKMVIEYNQAPSLRRQDIKLTSNMYNRVMTKDNISVITLLENKENGSRLIVANCHIHWDPQFRDVKVIQVAMLMDEIAQVATKFRNMPSKIPSDQLKDERPTYPEYLKIPILICGDFNSVQGSGVYDFLSSGSISQNHEDFMNNDYGEYTVNGRSHAFNLKSAYGESEALSFTNYTPGFKGAIDHIWYTGNSLEVTGLLKGVDKDYLSGVVGFPNAHFPSDHICLLAEFKVKQEKTPLPSSKFNNDKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MFNPRYTQGTIYPG -CCCCCCCCCCCCCC | 23.08 | 29996109 | |
| 10 | Phosphorylation | NPRYTQGTIYPGAHP CCCCCCCCCCCCCCC | 13.91 | 29996109 | |
| 12 | Phosphorylation | RYTQGTIYPGAHPGL CCCCCCCCCCCCCCC | 8.75 | 29996109 | |
| 21 | Phosphorylation | GAHPGLLTPDHQHAA CCCCCCCCCCCCCEE | 31.54 | 21712547 | |
| 31 | Phosphorylation | HQHAAILSVQNSPAL CCCEEEEEECCCHHH | 18.62 | 21712547 | |
| 35 | Phosphorylation | AILSVQNSPALENSN EEEEECCCHHHCCCC | 8.41 | 21712547 | |
| 61 | Phosphorylation | ATQSRSFSSPHQRAH HHHCCCCCCHHHHHH | 44.18 | 29996109 | |
| 62 | Phosphorylation | TQSRSFSSPHQRAHN HHCCCCCCHHHHHHH | 25.13 | 29996109 | |
| 302 | Phosphorylation | RGWEKLVSDDDDDVN CCHHHHCCCCCCCCC | 45.84 | 28889911 | |
| 313 | Phosphorylation | DDVNDNVSTSVRDLT CCCCCCCCHHHHHHH | 22.63 | 21712547 | |
| 472 | Phosphorylation | NMYNRVMTKDNISVI HHHHHHCCCCCEEEE | 32.18 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCR4_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCR4_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCR4_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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