SIB1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIB1_SCHPO
• UniProt AC: Q9P7T1
• Protein Name: Hydroxamate-type ferrichrome siderophore peptide synthetase
• Gene Name: sib1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 4924
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in intracellular and extracellular ferrichrome siderophore biosynthesis..
• Protein Sequence: MKNSNEEDAFSTQISQLGPMRPSSDAPYHVLSLPFSHPYSAFLDAWSWLFCGITGGEVSFFFFPVSDDVIPNTNPKNCQCYLYHSTNSQLEPLEVFHLHKLHSAVFTSRRDPSFADDLFESSKPCLNQLLSYFSDITAFRSMDVVADIAFVCSPNFLTLKWNSSLFDDDLARLLFFMINSKITNYDLPFSILNSPCSDLCLNSSSLANYLHGCFYHNTLSHPYQDALKFIYEIGDDLEDTFRSFSFLELHSLAIKLSKLVTCKNEVVPIMVSHSPALFVGILAILYSGNAYCPIDVETRTERVHFISKDVDASFAIVSEEFVNRFPNNTIILKVPEYNESMEIKVDDEIPPFPFPESLDSVAYVLYTSGSTGNPKGVAISHRAATNSIKSHGYLYPMFGLERGDAWLQFANVTFDVSVFEIFGNWNNGLTLVTSKRQNLIGNLEYLIYDYKIAALELTPTVANVISLDENKELFTSVRMLITIGELLTNRIIDFWGERLVNAYGPTEAAIHVTLNPSKALTTVYLVGVPLQSATICVVSLPTEDSQPHVLHEGFLGEVCIAGPQLSSGYINRPEINAKAFVEVQYNEQTLSIYRTGDLGRIINGKLYIFGRIAGDMQIKIRGRRIEIGEIESKLAPSVDSLAIEKIGDNLVAFYVGDEMKLRKHAESHLASWMCPTKYVGLPGFPRLASGKTDRKALKIQFSASDKHSTDFSSFNQSELLVANVLHEICEKRFNSVVSISRFSSIFDLGLDSLDIVYFVRKIRSLGFEANPSIVLTSKVVFKIAESLILLKPNEVQSKNNFLNKCTPLQKGMLYESFSNNGNLYFNHTVFKIAASPEKVKLAWEKLLDTHTILSNGFALDENEGFTRFILEKKPPLYSYSKNCLECIQKHFTTKEFDEQFLNSGPLDAAVIYDSSNCYLSIVWHHALYDGWSIDIIMQQLFMLIHDRRLTIVPQFEDYVQELESLRRLNYKNCISFWKKYLKDFKFKSLSYQREKMGVVELSSNISLLSVENICKQLQTTPLSFFLTAWSTVLSSYLKTNDFLVGTVVSGRVNSLLPNVDYVIGPCMQTLPVRIKLDDELSYKNLCQNLFKELSFVLKHSVMAISDFQEELLVSNLFESILIYQQSGIPSVDESFISLIHSTDHVEQPLLIEIEKNKGYKFKLTGYLSSELLNNLLNDFDKILNFILYNIESKIQTHASFNVTITEHNHVESKARTGFSKREEKLVRSCLSKILGNTVLSADVFENLQNYGFDSLCAMRFFSLLRKSSGIGNLKIPNMKSNPTIASLCELLVLPTETLSADNEITFYEVSDIQHEANLDIESFQYFPCTPMQQALLASSEKNGVEYYYNKYLFETGKSSQEEIYLLFKTLLNNLPILRTCFFVTRSKKYPYCQVVLNEPNFYFQVLPYKGESLSKYNLAEIPLLDSKKVPIQIFFLQGENKNYVLFCIHHVLYDAWAFQLIMDDINHLLRKENPKGSQSMLKFISYLHRYNKNVDLEIWSKIFLGFKPSKFPELCKDINPEQRTYKCNLSISLSQIDDLCNGFSFTTSTFLQCCWAKTLSFLLNSRDICFGNIISGRDVPVDEVVSLVAPTFNSFPLRVLLDSKLSFAEVCGQLQRLKETLQEHQMTSVQSICKSLTVKSLFDTVFIIQPQLLSDRTGPWKLLNESSSMDMRFIIELLLGSDDSPLTLVGTGTGKSGKLVCNLYKTILKHYVHYGLSTSVPLYTSLEKHNLISRSPSSPPPIHTNFDTNADIITLFEKEANEHPSSIALHFVYNVDKENIYSYKFFSEYSIKASYWLHSIGIKKNDVVAVFIDKSLDYYSLMLGVLRIGAFFFPLEHCSSLNFAKENLLRTNVKLLIVDKFLPFEDVNQVEIDKFRQVVDKLPTVEIPNESRSSAFIFPSYELAEGLTMMESSSFMDSIISFIDSTCFPSSSRWFQYAPSSTACQMFDCFMCWFFGCTLISGPQLFLKNNLKPLLLATHASHLITTSSIAASLKGEDIPSIQRLYCYEGPINNYMIKSWGSRLSYIYAFKPLICSCVPATEYLESNIMMVGIPLKGLIFAVVNSDTNTLAPIGSSGELCIASVKKSGNTMMDSQRVFTFENRSYYRTGDIVRILAGGEFEYIKKKSFIFIDSMPLDIEGKINVDKLRDLLNDDNYIFKVDNDEFPKNDNILDGFQEKVILTISDFASIPFEKLSLNTKLSTIGIDSISAIQLSKDLREIFHLRISALDILNSSTINSLIRKLKRRRTESHTRNDKIHESIDQFFKDIRKQILIPQTLCDKIEQILPCLASQCSMLSRFYTNGGKDYLNYSVFHLQKYNDPLLLRSSWENVISNVSILRTKFQTTKHKRSPFCQVTYSKVDIPWSMELHAASVEKVLNEYLELQRRDLLQGKNVLPYSLIFVRTFSQETFLIIIMHHALYDESSLRKILGLVEKSLNSPIGKFNHEPIVRQIELLKANYEEAKAFWIKQLLSFQPTNFPSLTACRIDNEDRMLTKKPCALNYTNLTKWCNAHDVTLQVLGQLVWAKILASYCAENYAVFGTVLSGKSVLTDVDDNIFPTVTTIPCVVKLQGTVEDCLRQLQKFNLDANKFQFTSLLDIKKWLNLGPSEKLFSSLFSIYVDNDIPLKLFNDECKAQGFIEFPVALEMRFSESTSELTLNSAVNYIPQAHASLILDQFNAILTTIFNNPLQQIEILENSLPTQLLSIKPAIVGDYPTEIKYLHQFVEYFAQKSPNSCALEFALDINQDSVQLIRLTYSELNERANKLAHNLKSYGFRVGSIIAVYFDKCIEAFISMLAILKAGCCFLALDVSAPTERIRYIVTDSTAVLVMSTGELYTKLLNASINVTILDASDPGNYSNNIENPYTKDFEDSNLAYVLYTSGSTGKPKGCCLTHHNVVQCMLAFQDQFAGEWDTNSRFLAFASFHFDVSVLEQYFSWSTGITLVAAPQSLILQDLPTAISALKITHVDLTPSLASILTPKTAPLLRVFITGGEQIKQELLNIWGDTRVLYNFWGPTELTIGASAFRKVPKNAKVSNIGPPFPNCSTYILSKETKVPVLLGGLGEICMGGNQVAKGYLNLPEQTDAKFYFDRRFNDRIYHTGDLGRLLKDNNSLEFCGRTDDQIKLRGQRIEIGEINAVIKSSSEKILGVYTLAVVHPVLRKQQLVAFIHVKGISASHLIVHDHKDPSLIGFINSACKASLAKYMVPSFYVFISSVPLTPTNKFDKKKVIEEFSRLSLGQLSSFAPAREENDNEGSNVVEPKLLKIIADFSDVKVTDISPQTSVFELGLDSISAVALSGLLRKSGYDNANPSLILTSSTISNLGFALNTQTNEELEDSIKVNSIIKLPSCSQFPFHQYIELINPCLPLVEGLLFELERSNNENYYNSFFFLFEKREQADQFINNFKLLRKQYEVLRSSFLKSDGEYFQVVWKSDFIAEVDVLNNDSLIKTVRYSLKCEKGFFLVTVTLFHGIYDGWSLDLLLNDLARLCSRKTLAPRPRYSKIVRQLLINTSLKKDTKEYWLNLFRSKNIYVPIFQGKLDMAITLGHKLSISSAKLSTICRSVLKASVNSALLTSWICFLNSIGAINCVGIVVSGRSEISMDCLEVMGPLFNTIPFPLFLEKDESFDCLVRRCQLTLASMIPYHQTSLREIKKWLRRSELFNVLFTYNLHPSVIKQCEFPWSFSSESTDTGYPLALEIEEDVDGTMNLHLSSNFKYIGQTEIIGLLDSYDCYLSSLLETSNAKISSRPNVLMPNQPEVKQYIPNVWNDVLKKLITILSPKVIITKLDFERDTFVHEFGIDSIDLIWLASKVSEAGIGKLDIGLLMEKPTFYRILQLLCETSANHSTSLKHEFGTLNTLLSKYLTDQDAEDCYPATPIQSGLLLETMNQKNLYQNDVLFSLDAEISLEKLQNSWKRLCQKNAILRTHFAISEDSSEPMVIQIVDKFEARSCLNQIKILPSRFTNIEDTLRFLRHDEEAKRFLDPFKNPPYYVQFFEIGAKNYMFVQMHHSLYDGWSLSLMYDELMQLYRDEQGNSRKPFKDYIIQLYSLKYDYDFWFKYFENLSIPKPLPFLSNNGKFMSSMMSTVSLPSVRLACQLYGVSIQSLVFFTWGYYIASVLNCPDIVFHTVLSGRTYIEGAETVMGPCMNTIPVRIKFEGALQTLKKTSRMLINLAKQQHTPLSWIYKTYGNVAAIPMESILVYQHLPDSSQSETFLNVVTDNSAVDYPIAIQFEIQGDTLNWLTSLDLARVDGDVANQLLQTIDKIFSNLTKGSFEKLTFNFSNFVKYRQYQINLKDFRENLLLTEEAISDCDLLIIDERVLVVFILFPEPDAKFPYLVLNEEIIRMLKSYIKKFRLTLSSAMVPDILVPVSYLPRSLDHSENEGKLLNIYNSISADNLKILSAVHEIHLNETEKILLEGFSKIICLPQDSVDISNNFFQLGMDSIRSIHLCSYLRNKGLNVSVSDILQHSSIEKLAHYLQYEKKESSSSFDIASFQLDEYLNTLPSNIPINLVQKILPCSAGQMYALNAWYNTEKKKYFHTFFYTTEEKIELLKLKLAWAKLVKSSDILRTTFIRSSSPCYPLLQIVLKSFECPWEHYITDNLHDTCLKIQKRELVTNTTLQEVPLRIATIETSGKFVFCLTIHHALYDGWSLDIMINYLSKMYYDDSLTIVQQNSQLFLSTVLDPAVGLSRKKFWNNYLTNYKPYTFLEKPSASQEITLFFPKLFSLDTVYSSVRSRGLTVQSVSFAVFARLLANEVKQEDVVFGIYVSGRTLDVDNIDELLFPTFNVVPLRVTDTFRPLGEIALEIQSFLNEISGNLQYISLLDLPVHGMMDIAVNFLSTGDNNEPSKVFSVYPLKLNNAELKINEVETTIDGCEILFGNKPKLDFELAIRDGYLEIGLFCQSSIFSKREASVFINNFVTIIKEIEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
752	O-(pantetheine 4'-phosphoryl)serine	IFDLGLDSLDIVYFV HHCCCCCCCCHHHHH	32.74	-
752	Phosphorylation	IFDLGLDSLDIVYFV HHCCCCCCCCHHHHH	32.74	-
1254	O-(pantetheine 4'-phosphoryl)serine	LQNYGFDSLCAMRFF HHHCCHHHHHHHHHH	24.08	-
2206	O-(pantetheine 4'-phosphoryl)serine	LSTIGIDSISAIQLS CEECCCCHHHHHHCC	19.27	-
2206	Phosphorylation	LSTIGIDSISAIQLS CEECCCCHHHHHHCC	19.27	-
3288	O-(pantetheine 4'-phosphoryl)serine	VFELGLDSISAVALS EEECCHHHHHHHHHH	24.40	-
3288	Phosphorylation	VFELGLDSISAVALS EEECCHHHHHHHHHH	24.40	-
3798	O-(pantetheine 4'-phosphoryl)serine	VHEFGIDSIDLIWLA CHHCCCCHHHHHHHH	18.97	-
4439	O-(pantetheine 4'-phosphoryl)serine	FFQLGMDSIRSIHLC HHHCCHHHHHHHHHH	15.82	-
4439	Phosphorylation	FFQLGMDSIRSIHLC HHHCCHHHHHHHHHH	15.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIB1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIB1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIB1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of SIB1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.