SSN2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SSN2_SCHPO
• UniProt AC: Q9HE02
• Protein Name: Mediator of RNA polymerase II transcription subunit 13
• Gene Name: srb9
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1225
• Subcellular Localization: Nucleus .
• Protein Description: Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex..
• Protein Sequence: MSYQVCFKKYVKMRQWPHVLSLRVYASYFLLYNNLPLSSAMVHDGVHLISIKTILTDQPCPNTIYYAKYQVQRKDNEDAASLLEDKEAYLRNQDCIVHAKNDLLFVYDFQAIPSIPEESSSFMLLNSGAFSRLALFQKDELALLLDLYINFLQGLKKTVLYWLCKEYNFVPIYGVLLPLKLHPSFDTQLWNIYGYPVVDLQLSVLSKGHIEFYLKPTRQTVYRLSEVDNLVKKLDTVIRLAPTGCLATLTSVHANASAQTVDALKHRYGFSLTTTSKWVGVTLESSALEFSWPLELCFLETSALRMNDDSLSSNLTDLNNLVLPSNVVNNKKELTEFANEEAEASDKRKEGFTEKEETADAVVTLVPSHSSSPVNYSINSAKSTPASIKVNEEILVADHNVSDDILMEEIDDVGITEADFDYFDLPNVEEKVEMIEPNFANTMTTLDNEEINTSISQSNTSPNLNTHENIPKQMEIQSDDRMVTEDLNPYNVEVDIPEISLNISDSKIPTSAYMPSYYSAVIFPSSISSIFQKYNYGGKYWCPSPSLSTEDLFESFSVAESVTSTDEDICSTNFIQQDFTMEYNHDFFSSSKTPTNISEQSNPDSNYDTLSLAHQVLMNESKSANFDFSFLKSLDLQPTITLGKNDLLNAILSQNLWFRSLPFWKSMTTSFMMSQDVLNFSSYMRKPIRDYLEKILLGESSAVFLSKSPENYLSSINNGHHALNDNPPSQVNFSETLVNFSQPPRVLLKYNEKKLSLDSSAPENWISLCLQPYGESKDFEVFLLSSKSPDVSSKAISFFYDVQLAYENCKLGKLNLSETSINERVMGFSTNINETDNYDDNETTQSDTATSYEQLASVCVNELSGKNVLFFYFLEDDSEKLLKACQHFICVKDSIKRLGDNKFEDKSLRICTIPNSIFDSPNSHTTNSNSFFTKVSLDIYNNDPLLMDGSLKRREPAFLLKKPLLSTLNYQLKDINPRSSALGEYALHVTYTTVEEHLLICNWNDSYGEFETERRYFLQDLEIEDALQQILEVTFTFLNSMHMDWIVIVMKIGEMSDAEYLFWDQAIIPENLQGNVSLTVGYCSAEHGPGSTSKVFSRIPYSASSTVIRNNSSHELSLVAFIREMAMPVPNDEFKKISTILARGYLALDEDESYLPLLSIHLLISRNHDPYLMLNLILKHYLSMIYLQFRTYVSFSSLPLHISTVLYQKQLLQFMASDITHPVTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1217	Phosphorylation	QLLQFMASDITHPVT HHHHHHHHCCCCCCC	20.12	25720772
1220	Phosphorylation	QFMASDITHPVTS-- HHHHHCCCCCCCC--	25.72	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SSN2_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SSN2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SSN2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MED7_SCHPO	med7	physical	12738880
MED17_SCHPO	srb4	physical	12738880
MED18_SCHPO	med18	physical	12738880
SRB8_SCHPO	srb8	physical	12738880
SSN3_SCHPO	srb10	physical	12738880
MED8_SCHPO	med8	physical	12738880
SRB11_SCHPO	srb11	physical	12738880
YEG5_SCHPO	mga2	genetic	19547744
EAF3_SCHPO	alp13	genetic	19547744
MED15_SCHPO	med15	physical	20622008
MED14_SCHPO	pmc1	physical	20622008
SRB8_SCHPO	srb8	physical	20622008
HRP1_SCHPO	hrp1	physical	20622008
MED17_SCHPO	srb4	physical	20622008
MED27_SCHPO	pmc3	physical	20622008
REB1_SCHPO	reb1	genetic	18818364
FKBP4_SCHPO	fkbp39	genetic	18818364
PNPP_SCHPO	pho2	genetic	18818364
PMP1_SCHPO	pmp1	genetic	18818364
HIR1_SCHPO	hip1	genetic	18818364
YG58_SCHPO	SPBC56F2.08c	genetic	18818364
RL16B_SCHPO	rpl1601	genetic	18818364
HPC2_SCHPO	hip4	genetic	18818364
DSC1_SCHPO	dsc1	genetic	18818364
RIK1_SCHPO	rik1	genetic	18818364
PP2C2_SCHPO	ptc2	genetic	18818364
CCR4_SCHPO	ccr4	genetic	18818364
VPH2_SCHPO	vph2	genetic	18818364
SSN3_SCHPO	srb10	genetic	25154415

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.