MED15_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED15_SCHPO
• UniProt AC: Q9Y808
• Protein Name: Mediator of RNA polymerase II transcription subunit 15
• Gene Name: med15
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 1063
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Component of a med15-hrp1 subcomplex, linking the Mediator complex to the chromatin-remodeling activity of hrp1 at a distinct subset of hrp1-bound gene promoters..
• Protein Sequence: MNRNVDKGWQAQIRPNERQSIALQIAQTLRIISPSISEVQLMNMALSFERQAFDGASSKNEYLTTCGKKTAQLRDQIRDTLQATQMKQMPSVYNNAGNVGALPTAGPNRLANNPRVMPRLQNQNVPMQAGMQQFARNMKLTPQQRQFLLQQSQIQQQRQQQQQQSQQPQQTQQPQASSPTAPNTEANQQRSGSVPGRIVPALTQQQLNNLCNQITALLARNGNPPIPMQKLQSMPPARLISIYQNQIQKFRSLQHMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQKQAPQNAFFPNPQGNVGAQSLQSMSPQDQPSTQQQQPQRTAAPPNNPNVNATNNNRINIEMLNIPVPKQLFDQIPNLPPNVKIWRDVLELGQSQRLPPEQLKLIGMLYRKHLQIILQHRQQQLNKIQNARMNSQNAPNTNKLGNPQPDNTGNPQAFSQQAFAQQQQQQQQQLHRTSNPTSASVTSQNGQQPINTKLSANAAKTNYQSYLTNKARNATQPTQPPVSQVDYSNNLPPNLDTSSTFRSSASPPSAFTKAGNEALSVPLSGARNTAASRPTNLAAGNSSASIVQQLLECGGTMGQQKMTSRIRELTERVMHSLMRPVPLDLPHDQKVMIASLIKSAYPMFSRTNQLICLFYCLTGNEEATIQLIQMRHIFKLQLEGLQQGVFTCAPQTLAKIKEKTSRYFAFVKAQLLRLHHEVNNNNMSIQNALAHISSLRTASINQQQQPQPQSQQQQQASQFPQAPSVSSNVRPINGSIPNAQPSVPGQAQPAAKANSVGNTSFPVDSKLAFQSLDVSQPDLQAKQKIASQVMKHGLKPEDLKLPPSKKKKIENLSTVQKPKDSVVNTPDVIMSSVDEIPSSVSPGTIAKEEGMAKAREEAIANPLKYAIDAFVAVDHEEEVSAIKSSQTPSSILKTPQSFFIPPSTPDLSFTDNKNSLSPSNILSLDGKFSFNDDSELWADLGNEINSEIGFLKEPDTMNLALDADKDKTKMQNKLTQINFDESCFLDPAIDDKDPWNEMLHEKKVLLKQLQVGNEDEDNIAFPTSTNIWQVVI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
528	Phosphorylation	NLPPNLDTSSTFRSS CCCCCCCCCHHCCCC		27738172
534	Phosphorylation	DTSSTFRSSASPPSA CCCHHCCCCCCCCHH		25720772
535	Phosphorylation	TSSTFRSSASPPSAF CCHHCCCCCCCCHHH		29996109
537	Phosphorylation	STFRSSASPPSAFTK HHCCCCCCCCHHHHC		25720772
786	Phosphorylation	QPAAKANSVGNTSFP CCCHHCCCCCCCCCC		25720772
856	Phosphorylation	PKDSVVNTPDVIMSS CCCCCCCCCCEEECC		29996109
869	Phosphorylation	SSVDEIPSSVSPGTI CCCCCCCCCCCCCCH		27738172
872	Phosphorylation	DEIPSSVSPGTIAKE CCCCCCCCCCCHHHH		29996109
875	Phosphorylation	PSSVSPGTIAKEEGM CCCCCCCCHHHHHCH		25720772
918	Phosphorylation	SAIKSSQTPSSILKT HHHHCCCCCHHHHCC		28889911
920	Phosphorylation	IKSSQTPSSILKTPQ HHCCCCCHHHHCCCC		29996109
921	Phosphorylation	KSSQTPSSILKTPQS HCCCCCHHHHCCCCC		29996109
928	Phosphorylation	SILKTPQSFFIPPST HHHCCCCCCCCCCCC		21712547
934	Phosphorylation	QSFFIPPSTPDLSFT CCCCCCCCCCCCCCC		25720772
935	Phosphorylation	SFFIPPSTPDLSFTD CCCCCCCCCCCCCCC		25720772
939	Phosphorylation	PPSTPDLSFTDNKNS CCCCCCCCCCCCCCC		25720772
941	Phosphorylation	STPDLSFTDNKNSLS CCCCCCCCCCCCCCC		25720772
946	Phosphorylation	SFTDNKNSLSPSNIL CCCCCCCCCCHHHCE		21712547
948	Phosphorylation	TDNKNSLSPSNILSL CCCCCCCCHHHCEEE		28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED15_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED15_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED15_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HRP1_SCHPO	hrp1	physical	20622008
CUT1_SCHPO	cut1	genetic	15507118
HRP1_SCHPO	hrp1	genetic	20622008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.