| UniProt ID | EAF3_SCHPO | |
|---|---|---|
| UniProt AC | O13953 | |
| Protein Name | Chromatin modification-related protein eaf3 | |
| Gene Name | alp13 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 337 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Also involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains.. | |
| Protein Sequence | MAVSYKVNERVLCFHGPLLYEAKIVDTEMKGDVTTYLIHYKGWKNSWDEWVEQDRILQWTEENLKTQKELKNAAISTRQKPTSKKSASSTSKHDSTGVKTSGKRSRESSTVTVDGDSHELPSRIKTQKSESPIPQQVKRDGTTDAKNEETTKPENNEKDDFEEEPPLPKHKISVPDVLKLWLVDDWENITKNQQLIAIPRNPTVRAAIAAFRESKISHLNNEIDVDVFEQAMAGLVIYFNKCLGNMLLYRFERQQYLEIRQQYPDTEMCDLYGVEHLIRLFVSLPELIDRTNMDSQSIECLLNYIEEFLKYLVLHKDEYFIKEYQNAPPNYRSLVGV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 105 | Phosphorylation | VKTSGKRSRESSTVT CCCCCCCCCCCCEEE | 43.83 | 28889911 | |
| 108 | Phosphorylation | SGKRSRESSTVTVDG CCCCCCCCCEEEECC | 30.14 | 29996109 | |
| 109 | Phosphorylation | GKRSRESSTVTVDGD CCCCCCCCEEEECCC | 23.34 | 25720772 | |
| 110 | Phosphorylation | KRSRESSTVTVDGDS CCCCCCCEEEECCCC | 29.49 | 25720772 | |
| 112 | Phosphorylation | SRESSTVTVDGDSHE CCCCCEEEECCCCCC | 16.99 | 29996109 | |
| 126 | Phosphorylation | ELPSRIKTQKSESPI CCCCCCCCCCCCCCC | 38.57 | 21712547 | |
| 129 | Phosphorylation | SRIKTQKSESPIPQQ CCCCCCCCCCCCCHH | 33.23 | 24763107 | |
| 131 | Phosphorylation | IKTQKSESPIPQQVK CCCCCCCCCCCHHHC | 34.91 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EAF3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EAF3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EAF3_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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