dbPTM

RGA8_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RGA8_SCHPO
UniProt AC	Q09697
Protein Name	Rho-GTPase-activating protein 8
Gene Name	rga8
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	777
Subcellular Localization	Cytoplasm . Localizes to the cell ends during interphase and to the septum-forming region during cytokinesis.
Protein Description	Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway..
Protein Sequence	MISSFSNGFWSKDYATGVKKLFDCLDNGVEENEQVKNLLKLYKEANEEFGEKLQEITKECLKGKKPENTEDGATSNKAFEGLRSEIANQGKQHIRIAKDLETLIIAPFSKMSIDHSQKLQTSQQVLTNQIKSYEKKYYTLKKTKSAYYNKCRNLEDYEEESKESNETTSEAITDLTTVSSPQQQSLLENDDDLIQLGFMEFRPEELKEVLAQVLQEIPLQDYRVPILGTYPNTCSGNIIVSWLQENLPVPTLVAAEAFGQDLIAQGFLRHMGVGGSFVNSTNFHYQWKDKAFQFAGLNSVDSLVENAKALPLVGEYLSDYISHRKLYSSETQSQRLKREVLDANKIYSESVVDLDKCRTLVEETIADHLQFLQKCETDRVLYYKDFFMDLSTIISNFLPSMKLLADQIVVYQEIIQPESDIRYILESAATGPFLPRVEIYEDYYNDIKDQIFGVDVEFLSHRDKKRVPIIVSTILSYLDLLYPTLASDEVRQNIWLVNSPLSSVHQLREALNHSSSVTKEVLSQYTPSVVIGVLKLYFLELPDSIVPSSAFELIRSIYMNHSNDTPYRLRLLQNLLSQLRRVNLATLSAIITHLNRLITLTPNKETFTINLANSLSLCISRPATWNLGIQHDKHPTKFMEDLLTYGPSIFEELRKLNSSKRVSDRVLYQSSATPRSTDVSPTRPDSISSVRSHTAVESPRSSFEELQPSEIPAESEFTLENVPTSLIRSSYALNTRKTRRNFSHSSASNESAAIFIDQDAKIVNEAVASRDSSLSGS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
663	Phosphorylation	LNSSKRVSDRVLYQS HCCCCCCCCCHHHCC	24.59	28889911
668	Phosphorylation	RVSDRVLYQSSATPR CCCCCHHHCCCCCCC	11.95	25720772
673	Phosphorylation	VLYQSSATPRSTDVS HHHCCCCCCCCCCCC	22.60	29996109
676	Phosphorylation	QSSATPRSTDVSPTR CCCCCCCCCCCCCCC	30.11	28889911
677	Phosphorylation	SSATPRSTDVSPTRP CCCCCCCCCCCCCCC	41.52	28889911
680	Phosphorylation	TPRSTDVSPTRPDSI CCCCCCCCCCCCCCC	24.30	28889911
682	Phosphorylation	RSTDVSPTRPDSISS CCCCCCCCCCCCCHH	47.53	28889911
686	Phosphorylation	VSPTRPDSISSVRSH CCCCCCCCCHHHHHC	27.36	28889911
688	Phosphorylation	PTRPDSISSVRSHTA CCCCCCCHHHHHCCC	27.08	25720772
689	Phosphorylation	TRPDSISSVRSHTAV CCCCCCHHHHHCCCC	21.63	28889911
694	Phosphorylation	ISSVRSHTAVESPRS CHHHHHCCCCCCCCC	33.38	28889911
698	Phosphorylation	RSHTAVESPRSSFEE HHCCCCCCCCCCHHH	21.00	28889911
701	Phosphorylation	TAVESPRSSFEELQP CCCCCCCCCHHHCCC	42.64	29996109
702	Phosphorylation	AVESPRSSFEELQPS CCCCCCCCHHHCCCC	37.65	29996109
709	Phosphorylation	SFEELQPSEIPAESE CHHHCCCCCCCCCCC	34.89	29996109
738	Phosphorylation	YALNTRKTRRNFSHS HHCCCCCCCCCCCCC	31.41	21712547
743	Phosphorylation	RKTRRNFSHSSASNE CCCCCCCCCCCCCCC	26.47	29996109
745	Phosphorylation	TRRNFSHSSASNESA CCCCCCCCCCCCCCC	26.80	21712547
746	Phosphorylation	RRNFSHSSASNESAA CCCCCCCCCCCCCCE	30.23	25720772
748	Phosphorylation	NFSHSSASNESAAIF CCCCCCCCCCCCEEE	42.98	29996109
751	Phosphorylation	HSSASNESAAIFIDQ CCCCCCCCCEEEECC	27.53	21712547
769	Phosphorylation	IVNEAVASRDSSLSG HHHHHHHCCCCCCCC	29.98	28889911
772	Phosphorylation	EAVASRDSSLSGS-- HHHHCCCCCCCCC--	31.88	21712547
773	Phosphorylation	AVASRDSSLSGS--- HHHCCCCCCCCC---	30.73	21712547
775	Phosphorylation	ASRDSSLSGS----- HCCCCCCCCC-----	38.65	24763107
777	Phosphorylation	RDSSLSGS------- CCCCCCCC-------	33.40	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RGA8_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RGA8_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RGA8_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STE20_SCHPO	shk1	physical	14506270
RGA8_SCHPO	rga8	physical	14506270
SHK2_SCHPO	shk2	physical	14506270

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RGA8_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-676; SER-680; THR-682;SER-686; THR-694 AND SER-698, AND MASS SPECTROMETRY.	18257517 [Abstract]