dbPTM

SHK2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHK2_SCHPO
UniProt AC	Q10056
Protein Name	Serine/threonine-protein kinase shk2
Gene Name	shk2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	589
Subcellular Localization
Protein Description	Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways..
Protein Sequence	MLLSVRGVPVEIPSLKDTKKSKGIIRSGWVMLKEDKMKYLPWTKKWLVLSSNSLSIYKGSKSESAQVTLLLKDIQKVERSKSRTFCFKLRFKSSTKNFEIQACELSVADNMECYEWMDLISSRALASKVSSPMNPKHQVHVGIDNEGNYVGLPKEWILLLQSSSITKQECMEEPKAVIQALDFYSKQLDTTSETKDSFSFCKETLPRSSTTSYSIRDADKHHKLTTSGVTKMNITERCKPKTTIQTDKKHIIRPFIEDKSHVESIMTGKVTKVPVKADSKNTLSRRMTDRQALAMLKDSVTSHDPVEYFNVKHKLGQGASGSVYLAKVVGGKQLGIFDSVAIKSIDLQCQTRKELILNEITVMRESIHPNIVTYLDSFLVRERHLWVVMEYMNAGSLTDIIEKSKLTEAQIARICLETCKGIQHLHARNIIHRDIKSDNVLLDNSGNIKITDFGFCARLSNRTNKRVTMVGTPYWMAPEVVKQNEYGTKVDIWSLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIFRATAAELLTHSFLNQACPTEDLKSIIFSRKANTHIN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of SHK2_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHK2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHK2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHK2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKH1_SCHPO	mkh1	genetic	11453249
SPM1_SCHPO	pmk1	genetic	11453249
MKH1_SCHPO	mkh1	physical	11453249
FHL1_SCHPO	fhl1	genetic	18931302
BYR2_SCHPO	byr2	genetic	9660817
RAD57_SCHPO	rad57	genetic	18818364
ELP3_SCHPO	elp3	genetic	18818364
TRM61_SCHPO	cpd1	genetic	18818364
FKBP4_SCHPO	fkbp39	genetic	18818364
MUG81_SCHPO	mug81	genetic	18818364
FBH1_SCHPO	fbh1	genetic	18818364
POB3_SCHPO	pob3	genetic	18818364
PYRE_SCHPO	ura5	genetic	18818364
MU154_SCHPO	mug154	genetic	18818364
AGO1_SCHPO	ago1	genetic	18818364
ELP2_SCHPO	elp2	genetic	18818364
BUT1_SCHPO	but1	genetic	18818364
CTK1_SCHPO	lsk1	genetic	18818364
YBPD_SCHPO	SPBC16H5.13	genetic	18818364
MUG89_SCHPO	mug89	genetic	18818364
EIF2A_SCHPO	SPBC4B4.04	genetic	18818364
YOFG_SCHPO	SPBP4H10.16c	genetic	18818364
URK1_SCHPO	SPCC162.11c	genetic	18818364
AAKB_SCHPO	amk2	genetic	18818364
SET1_SCHPO	set1	genetic	18818364
VAM7_SCHPO	SPCC594.06c	genetic	22681890
NEM1_SCHPO	nem1	genetic	22681890
ALG10_SCHPO	alg10	genetic	22681890
BCA1_SCHPO	eca39	genetic	22681890
HMT2_SCHPO	hmt2	genetic	22681890
ASH2_SCHPO	ash2	genetic	22681890
ALG5_SCHPO	alg5	genetic	22681890
CYB51_SCHPO	SPBC29A10.16c	genetic	22681890
RAF1_SCHPO	raf1	genetic	22681890
SHR3_SCHPO	psh3	genetic	22681890
MID1_SCHPO	mid1	genetic	22681890
MUG73_SCHPO	mug73	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHK2_SCHPO

Related Literatures of Post-Translational Modification