| UniProt ID | CTK1_SCHPO | |
|---|---|---|
| UniProt AC | O14098 | |
| Protein Name | CTD kinase subunit alpha | |
| Gene Name | lsk1 {ECO:0000312|EMBL:CAB16269.1} | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 593 | |
| Subcellular Localization | Nucleus, nucleolus . Localized to nucleus during all cell cycle phases. | |
| Protein Description | Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring. Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation.. | |
| Protein Sequence | MSYSKSTIYRRQGTEPNSHFRRTVEEKSQLSGTNEESLGGHTLSSNAFKNNSSSISPSSSAKDPREQRKRTFPLNDTHSSRARQHERPFRSRKSRRRKGKKAFSPRPGSPPSPSFYRSGSQKRARNLTTKDYFAKRSESSSSASVSPISPSANRNDSKRQASSFRRSPPSSVHMKPSAFNGRKVSRRPSSSPPPIPSIPHETTSSDTQKKSSVSSGFPENKHGKFHFHIPNERRSRFDQPPSKRMALTSTARESVPAPLPSPPSGPIYTYTYPKPAYEKIDQIGEGTYGKVYKAINTVTGDLVALKRIRLEQEKDGFPITTVREVKILQRLRHKNIVRLLEIMVEKSSVYMVFEYMDHDLTGVLLNSQLHFTPGNIKHLSKQIFEALAYLHHRGVLHRDIKGSNILLNNNGDLKFADFGLARFNTSSKSANYTNRVITLWFRPPELLLGETAYDTAVDIWSAGCIVMELFTGKPFFQGRDEISQLEVIYDMMGTPDVHSWPEVKNLPWYELLKPVEEKKSRFVETFKEILSPAAIDLCQKLLALNPFCRPSAHETLMHEYFTSESPPPEPAVILKNMQGSWHEWESKKRKSKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | SYSKSTIYRRQGTEP CCCCCCCHHCCCCCC | 10.38 | 25720772 | |
| 18 | Phosphorylation | RQGTEPNSHFRRTVE CCCCCCCCHHHHHHH | 34.42 | 25720772 | |
| 31 | Phosphorylation | VEEKSQLSGTNEESL HHHHHHCCCCCCCCC | 35.61 | 25720772 | |
| 52 | Phosphorylation | SNAFKNNSSSISPSS CCCCCCCCCCCCCCC | 34.55 | 25720772 | |
| 53 | Phosphorylation | NAFKNNSSSISPSSS CCCCCCCCCCCCCCC | 33.54 | 29996109 | |
| 54 | Phosphorylation | AFKNNSSSISPSSSA CCCCCCCCCCCCCCC | 27.23 | 29996109 | |
| 56 | Phosphorylation | KNNSSSISPSSSAKD CCCCCCCCCCCCCCC | 22.22 | 28889911 | |
| 58 | Phosphorylation | NSSSISPSSSAKDPR CCCCCCCCCCCCCHH | 30.08 | 28889911 | |
| 59 | Phosphorylation | SSSISPSSSAKDPRE CCCCCCCCCCCCHHH | 37.39 | 25720772 | |
| 60 | Phosphorylation | SSISPSSSAKDPREQ CCCCCCCCCCCHHHH | 43.61 | 29996109 | |
| 104 | Phosphorylation | RKGKKAFSPRPGSPP HCCCCCCCCCCCCCC | 25.51 | 28889911 | |
| 109 | Phosphorylation | AFSPRPGSPPSPSFY CCCCCCCCCCCHHHH | 36.00 | 28889911 | |
| 112 | Phosphorylation | PRPGSPPSPSFYRSG CCCCCCCCHHHHCCC | 36.24 | 24763107 | |
| 114 | Phosphorylation | PGSPPSPSFYRSGSQ CCCCCCHHHHCCCCH | 38.97 | 21712547 | |
| 116 | Phosphorylation | SPPSPSFYRSGSQKR CCCCHHHHCCCCHHH | 14.27 | 29996109 | |
| 120 | Phosphorylation | PSFYRSGSQKRARNL HHHHCCCCHHHHCCC | 33.50 | 21712547 | |
| 167 | Phosphorylation | QASSFRRSPPSSVHM HHHHHCCCCCCCCCC | 36.59 | 29996109 | |
| 185 | Phosphorylation | AFNGRKVSRRPSSSP CCCCCCCCCCCCCCC | 26.13 | 21712547 | |
| 189 | Phosphorylation | RKVSRRPSSSPPPIP CCCCCCCCCCCCCCC | 41.45 | 24763107 | |
| 190 | Phosphorylation | KVSRRPSSSPPPIPS CCCCCCCCCCCCCCC | 49.93 | 24763107 | |
| 191 | Phosphorylation | VSRRPSSSPPPIPSI CCCCCCCCCCCCCCC | 45.85 | 28889911 | |
| 197 | Phosphorylation | SSPPPIPSIPHETTS CCCCCCCCCCCCCCC | 49.85 | 21712547 | |
| 205 | Phosphorylation | IPHETTSSDTQKKSS CCCCCCCCCCCCCHH | 42.45 | 21712547 | |
| 207 | Phosphorylation | HETTSSDTQKKSSVS CCCCCCCCCCCHHHC | 44.21 | 21712547 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CTK1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CTK1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CTK1_SCHPO !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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