MSH6_SCHPO - dbPTM
MSH6_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MSH6_SCHPO
UniProt AC O74502
Protein Name DNA mismatch repair protein msh6
Gene Name msh6
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1254
Subcellular Localization Nucleus .
Protein Description Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops..
Protein Sequence MSVGNVGKQREKTKDSSAKTKQKTLFGFFSKIPNVKQEKSDSTLSSSSNHDSNHDTPADVDNSSNVNKNSSSPERELPTSPSHHANTEIDSSSSMLPPPSSDPFSSPLSSSLHRSSPKRPHDSLGEESPGKLLRTSVKQEPDSEEEIDSPTKKKSFKSLDTSIFQAEDQFRHPVSSKLENSELSEVDKPFIASRRSRKPVSYAESDEDEDFDDAPTKGSRHKRIVSDDESDDYVEPDHISEASSEASLPIDEVESMDEDVDGYSDHSVSVAAPIPKKESRKESSNSLYESYRLGSQIASPSPSVSGSASPTKSNKNGVLNREEKRRQRMEAFKKENNERYEWLLDVRDADQNRVGDPNYDPRTLYIPPSAWATFKPFEKQFWKIKKDLMDTVVFFQKGKFYELYENDAAIGHQVFSLKLTDRVNMKMVGIPEASFDYWASQFIAKGYRIARVDQLETALGKEIKDRQRTQKEEKVVQRGLTQVLTSGTLVDEAMLTSDLSTYCMAIKESLQSDNEEPSFGICFIDTSTGGFHMCEFTDDIHRTKLDTLLTQVRPKELILEKSKISQKSIRAIKYCVSSSSIWNFIKPYTEFWDNERVEREIIAGDYFKNGLEGAPKILKSYLSEKPLAISAFGALFWYLRQLKLDKDMCSMGNFDEYDASQQSTSLLMNGQTLKNLEIFSNSFDGGSEGTLFHLLCRCVTPFGKRLFHTWLCHPLRSGTAINARLDVVELIADNPVIRDTIWGFLHKLPDLERLISRVHAGRSKPADFVRVLEGFQRINSAFDQLREEFMEVAEGTLLGEIIQSAPNMKEELEAWTRAFNWQKASEEGVFEPEIGFEAEYDTSQKYQSELKNELYALLEQYKKQLRCSSLNFKNIGKEVYQVEVPSDVKVPVNWCKMSGTKKTNRYYNDELRKKIKKLLEAEELHLAIMSRMQEKFYIRFDSNYEQWLALIKYTASIDCFFSLSQAAAALGEPYCRPEIIEQKDGHLYFEELRHPCINASAASTFVPNDVVLGGESPNMIVLTGPNMAGKSTLLRQVCIAVIMAQLGCWVPAKRASITPMTSIYTRLGANDDIMSARSTFMVELSETKKILDECGPKSLVILDELGRGTSTYDGHAIAYAVLHHLVSNIGCLGFFSTHYQSLCVDFMHHRQVRLMQMAAAVDEKIRRVTFLYKLEDGICPKSYGMNVASMAGLPEKVIDAAEEKASELEQASASFINASDDIALMSDFLQVLRISKSIEPLTAVNIPLILDSFE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
115PhosphorylationLSSSLHRSSPKRPHD
CCHHCCCCCCCCCCC		40.0025720772
116PhosphorylationSSSLHRSSPKRPHDS
CHHCCCCCCCCCCCC		34.1025720772
123PhosphorylationSPKRPHDSLGEESPG
CCCCCCCCCCCCCCC		34.9325720772
128PhosphorylationHDSLGEESPGKLLRT
CCCCCCCCCCHHHHH		34.3524763107
143PhosphorylationSVKQEPDSEEEIDSP
CCCCCCCCHHHCCCC		58.5924763107
149PhosphorylationDSEEEIDSPTKKKSF
CCHHHCCCCCCCCCH		39.8829996109
151PhosphorylationEEEIDSPTKKKSFKS
HHHCCCCCCCCCHHH		60.4929996109
181PhosphorylationVSSKLENSELSEVDK
CCHHCCCCCCCCCCC		30.4529996109
184PhosphorylationKLENSELSEVDKPFI
HCCCCCCCCCCCCCH		31.3625720772
201PhosphorylationRRSRKPVSYAESDED
CCCCCCCCCCCCCCC		27.4425720772
202PhosphorylationRSRKPVSYAESDEDE
CCCCCCCCCCCCCCC		18.0229996109
205PhosphorylationKPVSYAESDEDEDFD
CCCCCCCCCCCCCCC		37.8228889911
299PhosphorylationRLGSQIASPSPSVSG
HHCCCCCCCCCCCCC		27.7828889911
301PhosphorylationGSQIASPSPSVSGSA
CCCCCCCCCCCCCCC		27.5829996109
303PhosphorylationQIASPSPSVSGSASP
CCCCCCCCCCCCCCC		33.0025720772
305PhosphorylationASPSPSVSGSASPTK
CCCCCCCCCCCCCCC		31.2225720772
307PhosphorylationPSPSVSGSASPTKSN
CCCCCCCCCCCCCCC		20.3328889911
309PhosphorylationPSVSGSASPTKSNKN
CCCCCCCCCCCCCCC		34.5028889911
311PhosphorylationVSGSASPTKSNKNGV
CCCCCCCCCCCCCCC		44.6129996109
1237PhosphorylationQVLRISKSIEPLTAV
HHHHHCCCCCCCCCC		25.9521712547
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MSH6_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MSH6_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MSH6_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MSH2_SCHPOmsh2genetic
11333218
RIK1_SCHPOrik1genetic
18931302
MRC1_SCHPOmrc1genetic
18931302
RAF1_SCHPOraf1genetic
18818364
AGO1_SCHPOago1genetic
18818364
RNC1_SCHPOrnc1genetic
18818364
RAF2_SCHPOraf2genetic
18818364
PCNA_SCHPOpcn1physical
22308326
DDB1_SCHPOddb1genetic
22681890
RIK1_SCHPOrik1genetic
22681890
SWI6_SCHPOswi6genetic
22681890
RAF2_SCHPOraf2genetic
22681890
YNVD_SCHPOfar10genetic
22681890
CLR4_SCHPOclr4genetic
22681890
YE08_SCHPOSPAC17H9.08genetic
22681890
PPR8_SCHPOppr8genetic
22681890
SSN3_SCHPOsrb10genetic
22681890
RAF1_SCHPOraf1genetic
22681890
RL27A_SCHPOrpl2701genetic
22681890
RAD22_SCHPOrad52physical
23779158
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MSH6_SCHPO

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; SER-299; SER-307AND SER-309, AND MASS SPECTROMETRY.

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