MRC1_SCHPO - dbPTM
MRC1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRC1_SCHPO
UniProt AC Q9P7T4
Protein Name Mediator of replication checkpoint protein 1
Gene Name mrc1
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1019
Subcellular Localization Nucleus . Associated with chromatin.
Protein Description Component of the replisome and is required for rad3-dependent activation of the checkpoint kinase cds1 in response to replication fork arrest. Phosphorylation allows it to mediate the activation of cds1..
Protein Sequence MASLDENADELHRMDSSDEASINDDQEDILDTPRTRVRKMLASVDMQLSSNAVSEASLDKESTVGNLENQKNRSYSSEIYLHSDTNFLSNFDSAYERVRRLLNQQGGKSSLQKKEVEQIETQEGGDNAKGSPSSENKDSDRNSRLQQLIEKKRNALKKEQEDLIQNSATSHSKSDNLDSESADDSDLADESELSKKYTSDRKIRNASKKALLELHRNTARLTRETALKPEVVVKKKVTLREFFQKIGFKNDNQLENKAISEEEANSTEPPNVEKEEPKPSVDRSTGIVNSEDIKELSVEDDSLELKEITPEALDIGQTSLFTTLNQTQVKKEDNKKFLLKEINAKLNEDDIDSELEIEVKPKTTALDNIEKSKLSEENEHGIKGKLKQLAEIKLSKDGKPFENEFNIKSFNRNLVKRAAVMAKLQRNQLEEELKAKGIYKPTIQGEKEEEEDPLERARNDAEKIRQLEKASGNASDEGELNDEEEVISSSNTPSTKAKTTNKVIISDVIIEATQAEPKRRQKNSRVVFDEEDLTGDSHGSSNMKISESDDESNGDMIRDSFDRLSSESIKDSQKTEELHDSFGINDEVDQSTSLYVQNSQPSASQLTIVDATYSQPPPRWESSSRDDKTNTSSTQPSQVDSLVPTQLDSTIPTQIDSVQRNKDQDDEEILEERRESRRDSKTFLSRTMLYNKDTGKADSAWASDLIEEQAIESDDEYAGIGGLSDDGLSDSDAELEVQNMIDDETTIQKGEVASMAQFAKDQEMDRDEKLVKQLMKDVTTGALRKRNRNGFAALDDSDDEDYSNLRREKLKELRRQKLLEDGNLNVLEGDKRKAFLATVEDSLVSSKDNLTWLDATVEDSGVGSSDLGDEYLYSEQSLNHEEEEQMEEELSEIFSSGGPNVVDRVYLKKSSTRHTSDNNSLEEVLPIFPGVRKLVSNSQSEKIGDLSNDNSMGAKSYKTPIISSTQRPQGRKFRGLMNQSSKADISRTVDAGSIKVVPNSQSANPPRLLASLNNYSDFD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
179PhosphorylationSKSDNLDSESADDSD
CCCCCCCCCCCCCCC		36.3025720772
181PhosphorylationSDNLDSESADDSDLA
CCCCCCCCCCCCCCC		40.7325720772
185PhosphorylationDSESADDSDLADESE
CCCCCCCCCCCCHHH		34.7625720772
353PhosphorylationLNEDDIDSELEIEVK
CCCCCCCCCEEEEEC		44.4024763107
471PhosphorylationIRQLEKASGNASDEG
HHHHHHHHCCCCCCC		43.5829996109
475PhosphorylationEKASGNASDEGELND
HHHHCCCCCCCCCCC		39.9529996109
548PhosphorylationSNMKISESDDESNGD
CCCCCCCCCCCCCCH		43.5029996109
604PhosphorylationQNSQPSASQLTIVDA
ECCCCCCCCEEEEEE		30.0214585996
634PhosphorylationDKTNTSSTQPSQVDS
CCCCCCCCCHHHHHH		44.2414585996
637PhosphorylationNTSSTQPSQVDSLVP
CCCCCCHHHHHHCCC		32.7714585996
645PhosphorylationQVDSLVPTQLDSTIP
HHHHCCCCCCCCCCC		33.9914585996
680PhosphorylationRRESRRDSKTFLSRT
HHHHHHHHHHHHHHH		31.6125720772
797PhosphorylationGFAALDDSDDEDYSN
CCCCCCCCCCCCHHH		46.7829996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRC1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRC1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRC1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDS1_SCHPOcds1genetic
11715017
CDS1_SCHPOcds1genetic
15226425
H2A1_SCHPOhta1genetic
15226425
H2A2_SCHPOhta2genetic
15226425
SET9_SCHPOset9genetic
15550243
CDS1_SCHPOcds1physical
14585996
RAD3_SCHPOrad3physical
14585996
ATM_SCHPOtel1physical
14585996
ORC2_SCHPOorc2genetic
18667534
NSE6_SCHPOnse6genetic
18931302
SWI6_SCHPOswi6genetic
18931302
DDB1_SCHPOddb1genetic
18931302
DCC1_SCHPOdcc1genetic
18931302
SRS2_SCHPOsrs2genetic
18931302
SWI1_SCHPOswi1physical
20924116
SWI3_SCHPOswi3physical
20924116
MRC1_SCHPOmrc1physical
20924116
TRM10_SCHPOtrm10genetic
18818364
SPC34_SCHPOspc34genetic
18818364
MCL1_SCHPOmcl1genetic
18818364
H31_SCHPOhht3genetic
18818364
RSV2_SCHPOrsv2genetic
18818364
PUS4_SCHPOSPBC11C11.10genetic
18818364
IRC3_SCHPOSPBC11C11.11cgenetic
18818364
YOH8_SCHPOleo1genetic
18818364
VRP1_SCHPOvrp1genetic
18818364
PNPP_SCHPOpho2genetic
18818364
KLP6_SCHPOklp6genetic
18818364
SIR2_SCHPOsir2genetic
18818364
YBPD_SCHPOSPBC16H5.13genetic
18818364
MLH1_SCHPOmlh1genetic
18818364
OPA3_SCHPOSPBC1703.11genetic
18818364
TOP1_SCHPOtop1genetic
18818364
HOP1_SCHPOhop1genetic
18818364
RAP1_SCHPOrap1genetic
18818364
HRD1_SCHPOhrd1genetic
18818364
NTO1_SCHPOnto1genetic
18818364
MAD2_SCHPOmad2genetic
18818364
YOU5_SCHPOpph3genetic
18818364
ASK1_SCHPOask1genetic
18818364
PDP1_SCHPOpdp1genetic
18818364
YGI3_SCHPOSPBC2A9.03genetic
18818364
YGI4_SCHPOsan1genetic
18818364
MYO51_SCHPOmyo51genetic
18818364
SYJ1_SCHPOsyj1genetic
18818364
RL16C_SCHPOrpl1603genetic
18818364
SWI3_SCHPOswi3genetic
18818364
TMA20_SCHPOtma20genetic
18818364
HIR1_SCHPOhip1genetic
18818364
RHP9_SCHPOcrb2genetic
18818364
YO48_SCHPOSPBC36B7.08cgenetic
18818364
CLR4_SCHPOclr4genetic
18818364
EIF2A_SCHPOSPBC4B4.04genetic
18818364
PTEN_SCHPOptn1genetic
18818364
IQW1_SCHPOiqw1genetic
18818364
POB3_SCHPOpob3genetic
18818364
RFA1_SCHPOssb1genetic
18818364
CLR3_SCHPOclr3genetic
18818364
TBA2_SCHPOatb2genetic
18818364
TAS3_SCHPOtas3genetic
18818364
DCN1_SCHPOSPBC839.03cgenetic
18818364
LUB1_SCHPOlub1genetic
18818364
CTF18_SCHPOctf18genetic
18818364
HPC2_SCHPOhip4genetic
18818364
PPME1_SCHPOSPBP4H10.17cgenetic
18818364
UTP16_SCHPOutp16genetic
18818364
YORN_SCHPOrnf10genetic
18818364
RIK1_SCHPOrik1genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
ERS1_SCHPOers1genetic
18818364
HRR1_SCHPOhrr1genetic
18818364
DCR1_SCHPOdcr1genetic
18818364
MSH6_SCHPOmsh6genetic
18818364
MU154_SCHPOmug154genetic
18818364
RAF1_SCHPOraf1genetic
18818364
AGO1_SCHPOago1genetic
18818364
RAF2_SCHPOraf2genetic
18818364
YK82_SCHPObdf2genetic
22095079
BDF1_SCHPObdf1genetic
22095079
ESA1_SCHPOmst1genetic
22095079
EAF_SCHPOvid21genetic
22095079
CDC45_SCHPOcdc45genetic
16849602
MCM2_SCHPOmcm2genetic
16849602
RL28B_SCHPOrpl2801genetic
22681890
ERFB_SCHPOerf2genetic
22681890
FEP1_SCHPOfep1genetic
22681890
ERFD_SCHPOerf4genetic
22681890
SEC14_SCHPOspo20genetic
22681890
OMH6_SCHPOomh6genetic
22681890
RAD26_SCHPOrad26genetic
15173168
CDS1_SCHPOcds1genetic
15173168
SWI1_SCHPOswi1physical
26771498
HSK1_SCHPOhsk1physical
28069740
SWI6_SCHPOswi6genetic
23478021
CHP1_SCHPOchp1genetic
23478021
CLR4_SCHPOclr4genetic
23478021
DCR1_SCHPOdcr1genetic
23478021
RIR2_SCHPOsuc22genetic
26746798
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MRC1_SCHPO

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Related Literatures of Post-Translational Modification

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