PDP1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDP1_SCHPO
• UniProt AC: O59676
• Protein Name: PWWP domain-containing protein 1
• Gene Name: pdp1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 359
• Subcellular Localization: Nucleus .
• Protein Description: Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly..
• Protein Sequence: MNNARTNAKRRRLSSKQGGLSISEGKESNIPSVVEESKDNLEQASADDRLNFGDRILVKAPGYPWWPALLLRRKETKDSLNTNSSFNVLYKVLFFPDFNFAWVKRNSVKPLLDSEIAKFLGSSKRKSKELIEAYEASKTPPDLKEESSTDEEMDSLSAAEEKPNFLQKRKYHWETSLDESDAESISSGSLMSITSISEMYGPTVASTSRSSTQLSDQRYPLSSNFDHRGEAKGKGKQPLKNPQERGRISPSSPLNDQTKALMQRLLFFRHKLQKAFLSPDHLIVEEDFYNASKYLNAISDIPFLNYELITSTKLAKVLKRIAFLEHLENDELYDIRQKCKNLLYSWAMFLPNEPSIKGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
249	Phosphorylation	PQERGRISPSSPLND HHHCCCCCCCCCCCH	19.85	28889911
251	Phosphorylation	ERGRISPSSPLNDQT HCCCCCCCCCCCHHH	37.48	21712547
252	Phosphorylation	RGRISPSSPLNDQTK CCCCCCCCCCCHHHH	36.47	19250904

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PDP1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDP1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDP1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SWI3_SCHPO	swi3	genetic	18818364
VPS72_SCHPO	swc2	genetic	18818364
ELP4_SCHPO	elp4	genetic	18818364
ERS1_SCHPO	ers1	genetic	18818364
SET5_SCHPO	set5	genetic	18818364
DCR1_SCHPO	dcr1	genetic	18818364
NUP61_SCHPO	nup61	genetic	18818364
RAF2_SCHPO	raf2	genetic	18818364
YGI3_SCHPO	SPBC2A9.03	genetic	18818364
WAPL_SCHPO	wpl1	genetic	18818364
KU80_SCHPO	pku80	genetic	18818364
MIT1_SCHPO	mit1	genetic	18818364
BDF1_SCHPO	bdf1	genetic	18818364
H4_SCHPO	hhf3	physical	22150589

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252, AND MASSSPECTROMETRY.
PubMed: 18257517