dbPTM

SET5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SET5_SCHPO
UniProt AC	O74467
Protein Name	SET domain-containing protein 5
Gene Name	set5
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	319
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description
Protein Sequence	MNPYETEIYKVVPIPNKGMGMIAKVKIPVGTRIFAETPLIRTKSDAKEIEEALSTKTKEEQEAFHRLFNAHPDTMGPFLGPFYSNALTIDETKGGMFLLGSRMNHDCSPNVKHTWNPRLDQVTVHAVRDIEAGEEILTTYIDLHKSHTERQKILLEHFGFKCYCSVCSVEERKIRKISDLRRKQLAYYDRTMAKMCIVNPRGALRALRHRIHIAHEELLFGRLDIIALLDAFRLCVIHGDFERASIFAKKGTKAISLYEGTDSEKYLKISKYVENPRSHALAEGVPALPLFLEEDDELSDLEDNLWGCKLEEDVYSDTD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
299	Phosphorylation	LEEDDELSDLEDNLW ECCCCCCCHHHHCCC	37.79	29996109
316	Phosphorylation	KLEEDVYSDTD---- CCCCCCCCCCC----	33.60	28889911
318	Phosphorylation	EEDVYSDTD------ CCCCCCCCC------	37.35	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SET5_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SET5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SET5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDS23_SCHPO	sds23	genetic	22681890
CG121_SCHPO	cgi121	genetic	22681890
YGWH_SCHPO	gmh4	genetic	22681890
COM1_SCHPO	ctp1	genetic	22681890
YOR2_SCHPO	rng9	genetic	22681890
ELP1_SCHPO	elp1	genetic	22681890
NPC2_SCHPO	SPAPB8E5.04c	genetic	22681890
SEC14_SCHPO	spo20	genetic	22681890
YKN4_SCHPO	mca1	genetic	22681890
YF3E_SCHPO	SPAC22A12.14c	genetic	22681890
SGF29_SCHPO	sgf29	genetic	22681890

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SET5_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316 AND THR-318, ANDMASS SPECTROMETRY.	18257517 [Abstract]