ELP1_SCHPO - dbPTM
ELP1_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ELP1_SCHPO
UniProt AC O59704
Protein Name Elongator complex protein 1
Gene Name iki3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 1253
Subcellular Localization Cytoplasm .
Protein Description Acts as component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme and is involved in transcriptional elongation. Association with elongating RNAPII requires a hyperphosphorylated state of the RNAPII C-terminal domain (CTD). Elongator binds to both naked and nucleosomal DNA, can acetylate both core and nucleosomal histones, and is involved in chromatin remodeling (By similarity)..
Protein Sequence MKNLVTHLHHVFPNVNGSIKALAFNSISDKIYVVCGLDNENPGIEIYEISENDDVSKLVEFDSPSFVSDNGDIDEIQSMQFLGEPMAICLSLKGGDIVMVKVDPSPEEAPWEIIGNVENGIVASCWSTDEQVFCIITGGDTILFMTKNFDIISETSLSDADLNEFNKHISVGWGRSETQFRGKRVRAKLRDPTLPEKIDEGKLSDVDDGKTYICWRGDSQYVSINRLEKGPRRAIRVYSREGLLDSISEPQDGQQSLLSWKPSGSVLATIKSDSSDNSSKVIFFERNGLRHGEFSLRRREDEKYTGLAWNVSSSILAVSTENSVMLWTTGNYHWYLKKEINIPQNALISWHPEHANTLYITGKNHIEKVVFDLKYVTEFSTSPNDFGLIPVIDGSSLLVTPLSLCNIPPPMCRYKLSLDYNVQMTSINATSDMLFAADDRRLTAFTFNSQEDIAKFGEFDISTYAEGLNFKSLLGLSGNQVLLLADGTNNCSKFFVFQCDEDNESLKLLASESFESCILNASYCSEMLFFQTSSGKLISYNLNVKSIESISLSFPKPCSDFVVVPVHETFVPIGLTSYGRLYAEQRLLSTGVLSFFCTERFVLFTTTKNLLKFVHLVSTVDDLQVVEDDAVDRHDERCRVVERGSKIVASMPSKMAVVLQMPRGNLETIYPRIMVLDGVRTYIKALKYGDAFKVCRTHRLDLNILFDYDPDLFLKNIPVFVDGLYRVDYLDLFLTSLKPENVTTGMYSDTSKSQSQQSVTTIDNKVNLLCKIIREHLTSKYGDTHFQAIITSYLCESPPKIEAALGMISGLIKAQSETVDLAIEHMCFLVDVNMLFDHALGLYDLKLALLIAQQSQKDPREYVPFLHEFQKQESLRRKFNIDCYLKRYERALGHLKEMENAFDEFKNFTIQHKLYPRALELYKYDKEAQKEVLIIFAQYLRENGKSNEAAIAYESVGKISEAIEAYKSAGMWRECLSILQQTTNSEDLIRETAEDLASLCIEKREHCDAGSINLLYLSNPREAVIQMCKGSQYSEAIRIARATGDSSIYKDLLISVLGESFGEASELVADFRNQIKSQTERILVLREKKKEDPISWMEGTMEDQTPDDISLASTSLSTNRSLYTQYTKSSNSSKMTRNTSKNNRRLERKRARGKKGTVFEEEYLVNSLRRLIARVEEIRPEVHRLLEALVRCNMTTQASELQRNFANVIGTIGEKVIPILSVPVSTFETALGEQPQAPVVPNVKPFEKLSILI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
753PhosphorylationMYSDTSKSQSQQSVT
CCCCCCCCCCCCCEE		34.5325720772
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ELP1_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ELP1_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ELP1_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
YHHB_SCHPOhmo1genetic
18931302
PLI1_SCHPOpli1genetic
18931302
VPS8_SCHPOvps8genetic
18931302
YKX1_SCHPOmsn5genetic
18931302
RYH1_SCHPOryh1genetic
18931302
TAS3_SCHPOtas3genetic
18818364
RIK1_SCHPOrik1genetic
18818364
PP2C2_SCHPOptc2genetic
18818364
HIF2_SCHPOhif2genetic
18818364
PEF1_SCHPOpef1genetic
18818364
MU154_SCHPOmug154genetic
18818364
RAF1_SCHPOraf1genetic
18818364
RAF2_SCHPOraf2genetic
18818364
EIF2A_SCHPOSPBC4B4.04genetic
18818364
UTP16_SCHPOutp16genetic
18818364
UBP3_SCHPOubp3genetic
18818364
RPA12_SCHPOrpa12genetic
18818364
NUP61_SCHPOnup61genetic
18818364
AAKB_SCHPOamk2genetic
18818364
BMT5_SCHPOSPCC1919.13cgenetic
18818364
CCR4_SCHPOccr4genetic
18818364
ELP2_SCHPOelp2genetic
18818364
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ELP1_SCHPO

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Related Literatures of Post-Translational Modification

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