WAPL_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WAPL_SCHPO
• UniProt AC: O94364
• Protein Name: Wings apart-like protein homolog 1
• Gene Name: wpl1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 602
• Subcellular Localization: Nucleus. Chromosome.
• Protein Description: Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin..
• Protein Sequence: MKRGKCKEKDNGLKRISSESEVWNFLDVTVSELNKQKRSPGQTVSKRLHKKQRVVSNPDLSLPSSPVKQILRNGLQNSKYGSHKTGLERSASCSSIDASANHSSTTYREQRSYLMEEGLDTQPIVPREVSSGRELDSTNHTIGTERAFLIEEDVSEDDEIQMKSIHELRFAGEQQRIVDEIEYLVDGVTFSGNSSASRYLSLIGIAEKMFDNSFRLCLKSIRDVFLRIFEEIDPKDTLHTFLQIYIFATMANEMDCMSSLLDAYSNNVKLLLQTAITLEPQVPVSILAKSLPKSVKGAVQEFVIKAELTFSFSNESLASSDSISLAAIALMKTSSGVFAESELFTELINLLIEKSYPILKENDGSNNFLLHALCSSLEKFTDFQGSEKIQKVSQILSSKLQILIDEHNETNSPKIDDTVVHACSEKLLRTLIQTVNSNSDHALAVSKSEVPLFAYKILQKFSNFSSDDETTRELIILILGLLLGLVEESHEFIQTITHVEVSFGASALDVLISFYQKNESIVEISGYVVMILSHCFLNDPKAFAQLKPLISQFYESLHKFKNFHLKLKEELMMMGSNGLAIVSIIDELHKSLQDYLRSDLVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	ELNKQKRSPGQTVSK HHHHCCCCCCCCHHH	40.18	24763107
56	Phosphorylation	HKKQRVVSNPDLSLP HHHCCCCCCCCCCCC	39.53	25720772
61	Phosphorylation	VVSNPDLSLPSSPVK CCCCCCCCCCCCHHH	45.69	24763107
64	Phosphorylation	NPDLSLPSSPVKQIL CCCCCCCCCHHHHHH	53.20	21712547
65	Phosphorylation	PDLSLPSSPVKQILR CCCCCCCCHHHHHHH	31.60	25720772
92	Phosphorylation	TGLERSASCSSIDAS CCCCCCCCCCCCCCC	18.77	25720772
95	Phosphorylation	ERSASCSSIDASANH CCCCCCCCCCCCCCC	28.90	25720772
155	Phosphorylation	FLIEEDVSEDDEIQM EEEECCCCCCCCCHH	47.86	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WAPL_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WAPL_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WAPL_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PEF1_SCHPO	pef1	genetic	18818364
YOI5_SCHPO	SPBC1778.05c	genetic	22681890
YGL1_SCHPO	psy2	genetic	28438891
YOU5_SCHPO	pph3	genetic	28438891

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.