| UniProt ID | ESA1_SCHPO | |
|---|---|---|
| UniProt AC | O94446 | |
| Protein Name | Histone acetyltransferase mst1 | |
| Gene Name | mst1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 463 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on H3K4me (By similarity).. | |
| Protein Sequence | MSNDVDDESKIETKSYEAKDIVYKSKVFAFKDGEYRKAEILMIQKRTRGVVYYVHYNDYNKRLDEWITIDNIDLSKGIEYPPPEKPKKAHGKGKSSKRPKAVDRRRSITAPSKTEPSTPSTEKPEPSTPSGESDHGSNAGNESLPLLEEDHKPESLSKEQEVERLRFSGSMVQNPHEIARIRNINKICIGDHEIEPWYFSPYPKEFSEVDIVYICSFCFCYYGSERQFQRHREKCTLQHPPGNEIYRDDYISFFEIDGRKQRTWCRNICLLSKLFLDHKMLYYDVDPFLFYCMCRRDEYGCHLVGYFSKEKESSENYNLACILTLPQYQRHGYGKLLIQFSYELTKREHKHGSPEKPLSDLGLISYRAYWAEQIINLVLGMRTETTIDELANKTSMTTNDVLHTLQALNMLKYYKGQFIICISDGIEQQYERLKNKKRRRINGDLLADWQPPVFHPSQLRFGW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ESA1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ESA1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ESA1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| FAT1_SCHPO | bud6 | physical | 18505873 | |
| CBH1_SCHPO | cbh1 | physical | 18505873 | |
| HIR1_SCHPO | hip1 | physical | 18505873 | |
| MSC1_SCHPO | msc1 | physical | 18505873 | |
| RAD22_SCHPO | rad52 | physical | 18505873 | |
| RES2_SCHPO | res2 | physical | 18505873 | |
| SEC18_SCHPO | sec18 | physical | 18505873 | |
| SKB1_SCHPO | skb1 | physical | 18505873 | |
| T111_SCHPO | taf111 | physical | 18505873 | |
| H2AZ_SCHPO | pht1 | physical | 19915592 | |
| MCM2_SCHPO | mcm2 | genetic | 18505873 | |
| MCM7_SCHPO | mcm7 | genetic | 18505873 | |
| ORC1_SCHPO | orc1 | genetic | 18505873 | |
| DPOA_SCHPO | pol1 | genetic | 18505873 | |
| HSK1_SCHPO | hsk1 | genetic | 18505873 | |
| RAD50_SCHPO | rad50 | genetic | 18505873 | |
| CLR3_SCHPO | clr3 | genetic | 18505873 | |
| CLR4_SCHPO | clr4 | genetic | 18505873 | |
| SWI6_SCHPO | swi6 | genetic | 18505873 | |
| ING1_SCHPO | png1 | physical | 20299455 | |
| RAD22_SCHPO | rad52 | genetic | 20299455 | |
| ARP4_SCHPO | alp5 | physical | 15483052 | |
| EPL1_SCHPO | epl1 | physical | 23695164 | |
| EPL1_SCHPO | epl1 | physical | 26771498 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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