MCM7_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM7_SCHPO
• UniProt AC: O75001
• Protein Name: DNA replication licensing factor mcm7
• Gene Name: mcm7
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 760
• Subcellular Localization: Nucleus .
• Protein Description: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Required for the progression of S phase..
• Protein Sequence: MALPTIDLKIPEYEECQHKITDFLSHFKQEQVQDGQQNQDISMSDAGDEPFLKSKYMDILQKISNRESNVINVDLNDLYEFDPSDTQLLHNIESNAKRFVELFSQCADALMPPPTVEINYRNEVLDVIMQQRVQRNENIDPEHKGFPPELTRGYDLYFRPVTRNKKPFSVRDLRGENLGSLLTVRGIVTRTSDVKPSLTVNAYTCDRCGYEVFQEIRQKTFLPMSECPSDECKKNDAKGQLFMSTRASKFLPFQEVKIQELTNQVPIGHIPRSLTVHLYGAITRSVNPGDIVDISGIFLPTPYTGFRAMRAGLLTDTYLECHYVSQIIKNYTNIEKTPQSEAAIAELNQGGNVYEKLAKSIAPEIYGHEDVKKALLLLLVGGVTKELGDGMRIRGDINICLTGDPGVAKSQLLKYISKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMDESDRTAIHEVMEQQTISISKAGITTTLNARTSILAAANPLYGRYNPKVAPIHNINLPAALLSRFDILFLILDTPSRETDEHLAQHVTYVHMHNEQPKMDFEPLDPNMIRHYISSARQYRPVVPKDVCDYVTGAYVQLRQNQKRDEANERQFAHTTPRTLLAILRMGQALARLRFSNRVEIGDVDEALRLMSVSKSSLYDDLDPSSHDTTITSKIYKIIRDMLNSIPDVEGNERSLTLRAIRERVLAKGFTEDHLINTIQEYTDLGVLLTTNNGQTIMFLDPDLHMEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	GQQNQDISMSDAGDE CCCCCCCCCCCCCCC	22.11	24763107
44	Phosphorylation	QNQDISMSDAGDEPF CCCCCCCCCCCCCHH	19.95	24763107

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM7_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM7_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM7_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAD3_SCHPO	rad3	genetic	11606526
CHK1_SCHPO	chk1	genetic	11606526
CDS1_SCHPO	cds1	genetic	11606526
MCM2_SCHPO	mcm2	genetic	11606526
MCM6_SCHPO	mcm6	genetic	11606526
HSK1_SCHPO	hsk1	genetic	11606526
HUS2_SCHPO	rqh1	genetic	11606526
MCM2_SCHPO	mcm2	physical	11606526
MCM3_SCHPO	mcm3	physical	11606526
MCM6_SCHPO	mcm6	physical	11606526
MCM7_SCHPO	mcm7	physical	11606526
CDC45_SCHPO	cdc45	physical	15338237
MCM2_SCHPO	mcm2	physical	9705352
MCM3_SCHPO	mcm3	physical	9705352
MCM6_SCHPO	mcm6	physical	9705352
MCM2_SCHPO	mcm2	physical	10770926
MCM3_SCHPO	mcm3	physical	10770926
MCM6_SCHPO	mcm6	physical	10770926
MCM2_SCHPO	mcm2	physical	21813639
YFF4_SCHPO	mcb1	physical	21813639
MCM6_SCHPO	mcm6	physical	21813639
MCM3_SCHPO	mcm3	physical	21813639
MCM7_SCHPO	mcm7	physical	23444842
MCM3_SCHPO	mcm3	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.