MCM6_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCM6_SCHPO
• UniProt AC: P49731
• Protein Name: DNA replication licensing factor mcm6
• Gene Name: mcm6
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 892
• Subcellular Localization: Nucleus .
• Protein Description: Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity)..
• Protein Sequence: MSSLASQGNNASTPAYRYGFQTSEVGDRPTVSMPSQPESSAMLEDDGMVKRKPFAAIGEAIPKVIDTTGESVREAFEEFLLSFSDDRVAGGDALPSASQEKYYVQQIHGLAMYEIHTVYVDYKHLTSYNDVLALAIVEQYYRFSPFLLRALQKLIEKFEPEYYRSSLSRENASLSPNFKASDKTFALAFYNLPFRSTIRDLRTDRIGRLTTITGTVTRTSEVRPELAQGTFICEECHTVVSNVEQAFRYTEPTQCPNELCANKRSWRLNISQSSFQDWQKVRIQENSNEIPTGSMPRTLDVILRGDIVERAKAGDKCAFTGILIAVPDVSQLGIPGVKPEAYRDSRNFGGRDADGVTGLKSLGVRDLTYKLSFLACMVQPDDANDKSGADVRGDGSQGIEEQDEFLQSLSQEEIDDLRAMVHSDHIYSRLTNSLAPSVYGHEIIKKGILLQLMGGVHKLTPEGINLRGDLNICIVGDPSTSKSQFLKYVCNFLPRAIYTSGKASSAAGLTAAVVKDEETGDFTIEAGALMLADNGICAIDEFDKMDLSDQVAIHEAMEQQTISIAKAGIQATLNARTSILAAANPIGGRYNRKTTLRNNINMSAPIMSRFDLFFVVLDECNESVDRHLAKHIVDIHRLRDDAMQPEFSTEQLQRYIRYARTFKPKLNTESCAEIVKKYKQLRMDDAQGAGKNSYRITVRQLESMIRLSEAIARANCVDDITPAFVNEAYSLLRQSIIHVERDDIEVEEDDAEAQELENDNTNTTNGNDNVSSEEALQKPKVKITYDKYVSIMNGILQVLRQRSTEGVDGVPAGDLVQSYLELREDQFHTEEDIIYEVGLVRKVLTRLVHESIIMEIQNLTDSAVRLPFEERVFSIHPNCDIDALLSNGDVPN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Phosphorylation	SMPSQPESSAMLEDD CCCCCCCCCCCCCCC	30.04	27738172
96	Phosphorylation	AGGDALPSASQEKYY CCCCCCCCHHHHHHH	41.21	28889911
98	Phosphorylation	GDALPSASQEKYYVQ CCCCCCHHHHHHHHH	43.12	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCM6_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCM6_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCM6_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUT1_SCHPO	cut1	genetic	15507118
DIS1_SCHPO	dis1	genetic	15507118
ALP14_SCHPO	alp14	genetic	15507118
MCM2_SCHPO	mcm2	physical	9658174
MCM7_SCHPO	mcm7	physical	11136247
CDC45_SCHPO	cdc45	physical	15338237
CDT1_SCHPO	cdt1	genetic	21971174
CDC18_SCHPO	cdc18	genetic	21971174
CDT1_SCHPO	cdt1	physical	21971174
CG22_SCHPO	cig2	genetic	21971174
CDC45_SCHPO	cdc45	physical	12006645
CG22_SCHPO	cig2	genetic	15194812
RUM1_SCHPO	rum1	genetic	15194812
SLD3_SCHPO	sld3	physical	15194812
MCM2_SCHPO	mcm2	genetic	15507118
BIR1_SCHPO	bir1	genetic	15507118
H31_SCHPO	hht3	genetic	15507118
H4_SCHPO	hhf3	genetic	15507118
MCM7_SCHPO	mcm7	physical	23444842
MCM6_SCHPO	mcm6	physical	23444842
HAP2_SCHPO	php2	physical	26771498
MCM3_SCHPO	mcm3	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96 AND SER-98, AND MASSSPECTROMETRY.
PubMed: 18257517