SLD3_SCHPO - dbPTM
SLD3_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SLD3_SCHPO
UniProt AC Q09761
Protein Name DNA replication regulator sld3
Gene Name sld3
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 699
Subcellular Localization Nucleus .
Protein Description Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis..
Protein Sequence MNNDHASKKSFCIKAPSNWEKSYLEVWPLVTVPRQCICLRWCISKEYHEFTCSSLQFIVIRPAGTSVLLGRVKSSKANQLVGIEHVEGSRYALIFLSEKLDFKSLKVIANHQLTKSSKSLSNVSNKPLGDQLFRSNSLMSPSLLKKELHRIQSDASQANERESQAPHSFVTHDLISSSKDGNSLTHEFANDSVTEMVQDYTPSCSRDVKSLLDHLYNSYFYQLLMTKTPVVFYVKQMVGKTRQLAVEVHNHVEEKALVDELLKFLDNLKSVDDRKSRLLQCFESHLNYKAWHLEFENEAHQYEIKGYRLWLQNILNRENCQITKLDFEREFSQLKLKEYEIRVLLYFEILYLFLKWDPEYARRRANDNSLLDSRDSGKRKSRKKNAKTLNPFETAQLKLEFTFDGLCIRRTIEQNATERSEDLLLKFCKETIVPYYSSKFPRITRNLLEKCNGLDLLPERSHKHRHSAPPRSKLISSKSEAGRALPGNTSGASISNTSSPHSEASISKDYEILKRRRSNSGVHSLTRSDSSFNGFERDTRRRSSDIARIKNREINLPSSSLSKQRNSMHDISTNFPRRNLSFTEKLTMASLQGQSEESVQPKTTSSLSRSKTLSILEGSVSKRSEPSMDSILVQATPRKSSSVITELPDTPIKMNSLDKASACTVENHIVTESPAHKSNKAQLFVCVPTTPVKKKSASP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
332PhosphorylationLDFEREFSQLKLKEY
CCHHHHHHHHCCCHH
29.8325720772
497PhosphorylationSGASISNTSSPHSEA
CCCCCCCCCCCCCCC
24.6429996109
502PhosphorylationSNTSSPHSEASISKD
CCCCCCCCCCCHHCC
37.9429996109
518PhosphorylationEILKRRRSNSGVHSL
HHHHHHHCCCCCCCC
33.2729996109
520PhosphorylationLKRRRSNSGVHSLTR
HHHHHCCCCCCCCCC
43.3629996109
671PhosphorylationTVENHIVTESPAHKS
EEECCEECCCCCCCC
30.0929996109
673PhosphorylationENHIVTESPAHKSNK
ECCEECCCCCCCCCC
20.3029996109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SLD3_SCHPO !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SLD3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SLD3_SCHPO !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDC45_SCHPOcdc45physical
12006645
HSK1_SCHPOhsk1physical
16990792
MCM2_SCHPOmcm2physical
21593208
RAD4_SCHPOrad4physical
21593208
PSF2_SCHPOpsf2physical
21593208
SLD2_SCHPOdrc1genetic
21593208
RAD4_SCHPOrad4physical
21945095
RAD4_SCHPOrad4physical
22433840
SLD2_SCHPOdrc1physical
22433840
CDC45_SCHPOcdc45genetic
12006645
MCM6_SCHPOmcm6physical
12006645
MCM7_SCHPOmcm7physical
12006645

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SLD3_SCHPO

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Related Literatures of Post-Translational Modification

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