| UniProt ID | SLD3_SCHPO | |
|---|---|---|
| UniProt AC | Q09761 | |
| Protein Name | DNA replication regulator sld3 | |
| Gene Name | sld3 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 699 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis.. | |
| Protein Sequence | MNNDHASKKSFCIKAPSNWEKSYLEVWPLVTVPRQCICLRWCISKEYHEFTCSSLQFIVIRPAGTSVLLGRVKSSKANQLVGIEHVEGSRYALIFLSEKLDFKSLKVIANHQLTKSSKSLSNVSNKPLGDQLFRSNSLMSPSLLKKELHRIQSDASQANERESQAPHSFVTHDLISSSKDGNSLTHEFANDSVTEMVQDYTPSCSRDVKSLLDHLYNSYFYQLLMTKTPVVFYVKQMVGKTRQLAVEVHNHVEEKALVDELLKFLDNLKSVDDRKSRLLQCFESHLNYKAWHLEFENEAHQYEIKGYRLWLQNILNRENCQITKLDFEREFSQLKLKEYEIRVLLYFEILYLFLKWDPEYARRRANDNSLLDSRDSGKRKSRKKNAKTLNPFETAQLKLEFTFDGLCIRRTIEQNATERSEDLLLKFCKETIVPYYSSKFPRITRNLLEKCNGLDLLPERSHKHRHSAPPRSKLISSKSEAGRALPGNTSGASISNTSSPHSEASISKDYEILKRRRSNSGVHSLTRSDSSFNGFERDTRRRSSDIARIKNREINLPSSSLSKQRNSMHDISTNFPRRNLSFTEKLTMASLQGQSEESVQPKTTSSLSRSKTLSILEGSVSKRSEPSMDSILVQATPRKSSSVITELPDTPIKMNSLDKASACTVENHIVTESPAHKSNKAQLFVCVPTTPVKKKSASP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 332 | Phosphorylation | LDFEREFSQLKLKEY CCHHHHHHHHCCCHH | 29.83 | 25720772 | |
| 497 | Phosphorylation | SGASISNTSSPHSEA CCCCCCCCCCCCCCC | 24.64 | 29996109 | |
| 502 | Phosphorylation | SNTSSPHSEASISKD CCCCCCCCCCCHHCC | 37.94 | 29996109 | |
| 518 | Phosphorylation | EILKRRRSNSGVHSL HHHHHHHCCCCCCCC | 33.27 | 29996109 | |
| 520 | Phosphorylation | LKRRRSNSGVHSLTR HHHHHCCCCCCCCCC | 43.36 | 29996109 | |
| 671 | Phosphorylation | TVENHIVTESPAHKS EEECCEECCCCCCCC | 30.09 | 29996109 | |
| 673 | Phosphorylation | ENHIVTESPAHKSNK ECCEECCCCCCCCCC | 20.30 | 29996109 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLD3_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLD3_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLD3_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CDC45_SCHPO | cdc45 | physical | 12006645 | |
| HSK1_SCHPO | hsk1 | physical | 16990792 | |
| MCM2_SCHPO | mcm2 | physical | 21593208 | |
| RAD4_SCHPO | rad4 | physical | 21593208 | |
| PSF2_SCHPO | psf2 | physical | 21593208 | |
| SLD2_SCHPO | drc1 | genetic | 21593208 | |
| RAD4_SCHPO | rad4 | physical | 21945095 | |
| RAD4_SCHPO | rad4 | physical | 22433840 | |
| SLD2_SCHPO | drc1 | physical | 22433840 | |
| CDC45_SCHPO | cdc45 | genetic | 12006645 | |
| MCM6_SCHPO | mcm6 | physical | 12006645 | |
| MCM7_SCHPO | mcm7 | physical | 12006645 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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