UniProt ID | SLD3_SCHPO | |
---|---|---|
UniProt AC | Q09761 | |
Protein Name | DNA replication regulator sld3 | |
Gene Name | sld3 | |
Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
Sequence Length | 699 | |
Subcellular Localization | Nucleus . | |
Protein Description | Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis.. | |
Protein Sequence | MNNDHASKKSFCIKAPSNWEKSYLEVWPLVTVPRQCICLRWCISKEYHEFTCSSLQFIVIRPAGTSVLLGRVKSSKANQLVGIEHVEGSRYALIFLSEKLDFKSLKVIANHQLTKSSKSLSNVSNKPLGDQLFRSNSLMSPSLLKKELHRIQSDASQANERESQAPHSFVTHDLISSSKDGNSLTHEFANDSVTEMVQDYTPSCSRDVKSLLDHLYNSYFYQLLMTKTPVVFYVKQMVGKTRQLAVEVHNHVEEKALVDELLKFLDNLKSVDDRKSRLLQCFESHLNYKAWHLEFENEAHQYEIKGYRLWLQNILNRENCQITKLDFEREFSQLKLKEYEIRVLLYFEILYLFLKWDPEYARRRANDNSLLDSRDSGKRKSRKKNAKTLNPFETAQLKLEFTFDGLCIRRTIEQNATERSEDLLLKFCKETIVPYYSSKFPRITRNLLEKCNGLDLLPERSHKHRHSAPPRSKLISSKSEAGRALPGNTSGASISNTSSPHSEASISKDYEILKRRRSNSGVHSLTRSDSSFNGFERDTRRRSSDIARIKNREINLPSSSLSKQRNSMHDISTNFPRRNLSFTEKLTMASLQGQSEESVQPKTTSSLSRSKTLSILEGSVSKRSEPSMDSILVQATPRKSSSVITELPDTPIKMNSLDKASACTVENHIVTESPAHKSNKAQLFVCVPTTPVKKKSASP | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
332 | Phosphorylation | LDFEREFSQLKLKEY CCHHHHHHHHCCCHH | 29.83 | 25720772 | |
497 | Phosphorylation | SGASISNTSSPHSEA CCCCCCCCCCCCCCC | 24.64 | 29996109 | |
502 | Phosphorylation | SNTSSPHSEASISKD CCCCCCCCCCCHHCC | 37.94 | 29996109 | |
518 | Phosphorylation | EILKRRRSNSGVHSL HHHHHHHCCCCCCCC | 33.27 | 29996109 | |
520 | Phosphorylation | LKRRRSNSGVHSLTR HHHHHCCCCCCCCCC | 43.36 | 29996109 | |
671 | Phosphorylation | TVENHIVTESPAHKS EEECCEECCCCCCCC | 30.09 | 29996109 | |
673 | Phosphorylation | ENHIVTESPAHKSNK ECCEECCCCCCCCCC | 20.30 | 29996109 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SLD3_SCHPO !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SLD3_SCHPO !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SLD3_SCHPO !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
CDC45_SCHPO | cdc45 | physical | 12006645 | |
HSK1_SCHPO | hsk1 | physical | 16990792 | |
MCM2_SCHPO | mcm2 | physical | 21593208 | |
RAD4_SCHPO | rad4 | physical | 21593208 | |
PSF2_SCHPO | psf2 | physical | 21593208 | |
SLD2_SCHPO | drc1 | genetic | 21593208 | |
RAD4_SCHPO | rad4 | physical | 21945095 | |
RAD4_SCHPO | rad4 | physical | 22433840 | |
SLD2_SCHPO | drc1 | physical | 22433840 | |
CDC45_SCHPO | cdc45 | genetic | 12006645 | |
MCM6_SCHPO | mcm6 | physical | 12006645 | |
MCM7_SCHPO | mcm7 | physical | 12006645 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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