RAD4_SCHPO - dbPTM
RAD4_SCHPO - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RAD4_SCHPO
UniProt AC P32372
Protein Name S-M checkpoint control protein rad4
Gene Name rad4
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length 648
Subcellular Localization Nucleus.
Protein Description Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. [PubMed: 8343962]
Protein Sequence MGSSKPLKGFVICCTSIDLKQRTEISTKATKLGAAYRSDFTKDVTHLIAGDFDTPKYKFAAKSRPDIKIMSSEWIPVLYESWVQGEDLDDGLLVDKHFLPTLFKCRVCLTNIGQPERSRIENYVLKHGGTFCPDLTRDVTHLIAGTSSGRKYEYALKWKINVVCVEWLWQSIQRNAVLEPQYFQLDMPAEKIGLGAYVRLDPNTTEAKSYSENQKISKNKEKSGQSLAALAEEADLEPVIMKRGKKRDRSILWEELNNGKFEFSSRSEENSVLLDDFTPETVQPLEENELDTELNIENEAKLFKNLTFYLYEFPNTKVSRLHKCLSDNGGQISEFLSSTIDFVVIPHYFPVDELPIFSFPTVNEWWIERCLYYKKIFGIDEHALAKPFFRPSLVPYFNGLSIHLTGFKGEELSHLKKALTILGAVVHEFLGVQRSILLVNTNEPFSMKTRFKIQHATEWNVRVVGVAWLWNIIQSGKFIDQVSPWAIDKKENQEIKKFTNQNNMVFPTSDRDTRLQNSLAQQPIGHSTPHNSPSLLSVKKRQNNHIRSNTLIQLNSNSKDSTIFPRRSVTVPGDKIDTVWKSSVTKPETPTSPQEHVSYIDPDAQREKHKLYAQLTSNVDAIPPANDLQNQENGLLLITESHRKLRRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
513PhosphorylationFPTSDRDTRLQNSLA
CCCCCHHHHHHHHHC		33.8921712547
518PhosphorylationRDTRLQNSLAQQPIG
HHHHHHHHHCCCCCC		16.4821712547
527PhosphorylationAQQPIGHSTPHNSPS
CCCCCCCCCCCCCCC		38.1229996109
528PhosphorylationQQPIGHSTPHNSPSL
CCCCCCCCCCCCCCC		23.9329996109
532PhosphorylationGHSTPHNSPSLLSVK
CCCCCCCCCCCCHHH		16.9025720772
534PhosphorylationSTPHNSPSLLSVKKR
CCCCCCCCCCHHHHC		41.5921712547
585PhosphorylationTVWKSSVTKPETPTS
EEEECCCCCCCCCCC		42.7129996109
589PhosphorylationSSVTKPETPTSPQEH
CCCCCCCCCCCCCHH		40.1529996109
591PhosphorylationVTKPETPTSPQEHVS
CCCCCCCCCCCHHCC		61.5325720772
592PhosphorylationTKPETPTSPQEHVSY
CCCCCCCCCCHHCCC		26.2828889911
598PhosphorylationTSPQEHVSYIDPDAQ
CCCCHHCCCCCCHHH		20.4829996109
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RAD4_SCHPO !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RAD4_SCHPO !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RAD4_SCHPO !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHK1_SCHPOchk1genetic
16723501
RIR1_SCHPOcdc22genetic
9268024
RHP9_SCHPOcrb2genetic
9407031
RHP9_SCHPOcrb2physical
16778077
RAD3_SCHPOrad3physical
16723501
HUS1_SCHPOhus1physical
16723501
RAD17_SCHPOrad17physical
16723501
DPB2_SCHPOdpb2physical
16723501
IPI3_SCHPOcrb3physical
16723501
CHK1_SCHPOchk1physical
16723501
SLD2_SCHPOdrc1physical
11937031
RAD9_SCHPOrad9physical
15155581
RAD3_SCHPOrad3physical
15155581
RHP9_SCHPOcrb2physical
9407031
IPI3_SCHPOcrb3physical
9407031
CDC45_SCHPOcdc45physical
15338237
PSF3_SCHPOpsf3physical
16990792
RHP9_SCHPOcrb2physical
15229228
YQ61_SCHPOSPCC191.01genetic
17272281
MPIP_SCHPOcdc25genetic
7957098
HSK1_SCHPOhsk1physical
21095590
HIM1_SCHPOdfp1physical
21095590
IPI3_SCHPOcrb3genetic
16723501
RAD9_SCHPOrad9genetic
22761595
RL38A_SCHPOrpl3801genetic
22681890
SEC14_SCHPOspo20genetic
22681890
CDK1_SCHPOcdc2genetic
7957098
CG23_SCHPOcdc13genetic
7957098
SLD2_SCHPOdrc1genetic
11937031
RHP9_SCHPOcrb2physical
24074952
CG23_SCHPOcdc13physical
24074952
CDS1_SCHPOcds1genetic
24663817
RHP9_SCHPOcrb2physical
24663817
RAD9_SCHPOrad9physical
24663817
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RAD4_SCHPO

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-592, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory