| UniProt ID | HIM1_SCHPO | |
|---|---|---|
| UniProt AC | O59836 | |
| Protein Name | Hsk1-interacting molecule 1 | |
| Gene Name | him1 | |
| Organism | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). | |
| Sequence Length | 545 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Activates hsk1 kinase and is essential for G1/S transition. Has a role in S-phase checkpoint control induced by replication fork blocks after nucleotide deprivation and DNA damage.. | |
| Protein Sequence | MNLGRCPLAPRSANIVLPKHDAVSKQKEYRIEEKTNEAQREEIITWKDNREDEGEVKTDFEVVNNENIITTTPKHQTVITPKSYRKSVKRIKHDAPQNEDIPVMKGLAPINADTESKAESMAAGKVLGSKNSSQKARLQEWKRQYKKAFPHFRFYLDGCDPSVAHRVKKQIQQLGGHVETFFSGNVTHVATVRAIQDVSVKYAKQDVITKARQLNMKIWSMEKLCNRVLKTLMENDQCTTNAPTKQGNDLSYLLYVEKVQGTNERDLSVPRQDFVHFRGPYLYVHDIANIYKPILLREWQKPLPDRDVPWPTFRATSIGRCPFVPETKYRLSTSKSLVAKNDQQLLQRQSQEPSLILRANSMKASLPDISNTGISGMNTNTTYNTNINNTPQTAISGITQDTSPSIRTNCHHCLDDGMQASGIVQSNLTSAAMSNNSAIRSGSAASVPVVTINGRDIAELKKRIIQQKSGMIGKDYSYKAMLHNTSQRKIRVDAKPGYCENCREKFDNFESHIRSSRHRRFAENNDNFKDLDELFALVQRPLRPD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 58 | Phosphorylation | EDEGEVKTDFEVVNN CCCCCCCCCEEEECC | 51.61 | 21712547 | |
| 72 | Phosphorylation | NENIITTTPKHQTVI CCCCEECCCCCCEEC | 22.99 | 21712547 | |
| 77 | Phosphorylation | TTTPKHQTVITPKSY ECCCCCCEECCCHHH | 17.37 | 24763107 | |
| 80 | Phosphorylation | PKHQTVITPKSYRKS CCCCEECCCHHHHHH | 21.96 | 21712547 | |
| 199 | Phosphorylation | VRAIQDVSVKYAKQD EEEEEEECHHHHCHH | 22.60 | 29996109 | |
| 268 | Phosphorylation | GTNERDLSVPRQDFV CCCCCCCCCCHHHCE | 34.07 | 25720772 | |
| 361 | Phosphorylation | SLILRANSMKASLPD HHHHHHHCCCCCCCC | 22.22 | 27738172 | |
| 441 | Phosphorylation | SNNSAIRSGSAASVP HCCHHHHCCCCCCCC | 30.87 | 25720772 | |
| 443 | Phosphorylation | NSAIRSGSAASVPVV CHHHHCCCCCCCCEE | 23.16 | 25720772 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HIM1_SCHPO !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HIM1_SCHPO !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HIM1_SCHPO !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| SWI1_SCHPO | swi1 | genetic | 15767681 | |
| SWI3_SCHPO | swi3 | genetic | 15767681 | |
| HSK1_SCHPO | hsk1 | physical | 12604790 | |
| HSK1_SCHPO | hsk1 | physical | 11402029 | |
| SWI6_SCHPO | swi6 | physical | 14625560 | |
| HSK1_SCHPO | hsk1 | physical | 10411894 | |
| HSK1_SCHPO | hsk1 | physical | 10409743 | |
| AMS2_SCHPO | ams2 | physical | 20230746 | |
| SWI1_SCHPO | swi1 | genetic | 20176980 | |
| PCNA_SCHPO | pcn1 | genetic | 20176980 | |
| RAD18_SCHPO | rhp18 | genetic | 20176980 | |
| MMS2_SCHPO | mms2 | genetic | 20176980 | |
| SRS2_SCHPO | srs2 | genetic | 20176980 | |
| MRC1_SCHPO | mrc1 | genetic | 22024164 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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