dbPTM

SRS2_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SRS2_SCHPO
UniProt AC	Q10213
Protein Name	ATP-dependent DNA helicase srs2
Gene Name	srs2
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	887
Subcellular Localization	Nucleus.
Protein Description	ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks..
Protein Sequence	METKSSYLKFLNEEQRISVQSPHKYTQILAGPGSGKTRVLTARVAYLLQKNHIAAEDLIIATFTNKAANEIKLRIEAILGNSEASKLISGTFHSIAYKYLVKYGKHIGLSSNWLIADRNDTQAIMKRLLDSLKKAKNPIASGIRGQELTPQNALNRITKLKSNGLLVKPGMDQLSLINGLEEPPKELQSHQSVELYRLYQTSLWKNNLADFDDLLLNFILLLQKQPDCVRNIKHILIDEFQDTSKIQYFLVKLLALQNSDITIVGDPDQSIYGFRSAEIRNLNQMSEDFEGTQVLHLERNYRSAKPILELALSIISQDKSRPKKGLKSNHISSLKPHYRLFETNNKESYWIAREIKRIVGSCPELIFYNDIAILVRSSSLTRSLEHALSELGVPYRMVGVNKFFDREEIRDLIAYLRVLANKDSTSLIRVINVPPRNIGKTKIDRIIFESERRGLTFWQTLNEVKNENILLSQRNDKSFLKSLKSFLCSISKLENRYLSNGHSATLSDLLLGILSEIKYYEYLVRKNKETVEEKWENVMELVQQSDNISCIFYELDYKISTIVLLQNFLTQIALVNEEQKEGESQKVTISTLHAAKGLEWPVVFLPCLCENIIPHSRSDDLDEERRLLYVGATRAQALLYLSSFKSVTGMFADMQNSDNVQDVSPFLKGEEMKRWVMESEIVFNEKIASEIGTILGRKSYGKITNLSGIGSNANHNGTKFENLGFQCCRVLAEAELKKRERVKSVNDYNKDETNFRKHNAKRSKTDIRSWFEKKQPIDSDVEISEPSRSASIMVANKDLNDRSFETVNRIVSTRASTTNASFMSSVRQNLGRGPSTKDQVINRTLREGHQDVVQHTDLNQSNTKVASARPAGSRKRLGVRLRVSRML

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
779	Phosphorylation	EKKQPIDSDVEISEP HHCCCCCCCCCCCCC	44.25	25720772
873	Phosphorylation	ASARPAGSRKRLGVR EECCCCCCHHHHCCE	36.41	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SRS2_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SRS2_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SRS2_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MUS81_SCHPO	mus81	genetic	14993467
RAD57_SCHPO	rad57	genetic	14993467
HUS2_SCHPO	rqh1	genetic	14993467
HUS2_SCHPO	rqh1	genetic	11452021
RAD22_SCHPO	rad52	genetic	11452021
RAD54_SCHPO	rad54	genetic	11452021
RAD13_SCHPO	rad13	genetic	11452021
HUS2_SCHPO	rqh1	genetic	12409469
RAD54_SCHPO	rad54	genetic	12409469
FBH1_SCHPO	fbh1	genetic	16135800
RAD55_SCHPO	rad55	genetic	16135800
RAD57_SCHPO	rad57	genetic	16135799
SWS1_SCHPO	sws1	physical	16710300
RAD3_SCHPO	rad3	genetic	17893680
HUS2_SCHPO	rqh1	genetic	17893680
NSE6_SCHPO	nse6	genetic	18931302
YA7D_SCHPO	SPAC24H6.13	genetic	18931302
PNK1_SCHPO	pnk1	genetic	18931302
RHP41_SCHPO	rhp41	genetic	18931302
SWR1_SCHPO	swr1	genetic	18931302
CSK1_SCHPO	csk1	genetic	18231579
RAD54_SCHPO	rad54	genetic	18426916
RAD55_SCHPO	rad55	genetic	14993467
UBC2_SCHPO	rhp6	genetic	14993467
RAD18_SCHPO	rhp18	genetic	14993467
RAD5_SCHPO	rad8	genetic	14993467
HSK1_SCHPO	hsk1	genetic	20176980
SWS1_SCHPO	sws1	genetic	16710300
RAD26_SCHPO	rad26	genetic	18818364
MCL1_SCHPO	mcl1	genetic	18818364
SRB11_SCHPO	srb11	genetic	18818364
ASK1_SCHPO	ask1	genetic	18818364
SWI3_SCHPO	swi3	genetic	18818364
FBH1_SCHPO	fbh1	genetic	18818364
RHP9_SCHPO	crb2	genetic	18818364
APN2_SCHPO	apn2	genetic	18818364
EIF2A_SCHPO	SPBC4B4.04	genetic	18818364
YG58_SCHPO	SPBC56F2.08c	genetic	18818364
RAD14_SCHPO	rhp14	genetic	18818364
MU154_SCHPO	mug154	genetic	18818364
TAS3_SCHPO	tas3	genetic	18818364
DCN1_SCHPO	SPBC839.03c	genetic	18818364
RL1DA_SCHPO	SPCC306.07c	genetic	18818364
BRC1_SCHPO	brc1	genetic	22366461
NSE6_SCHPO	nse6	genetic	22681890
HRQ1_SCHPO	hrq1	genetic	22681890
YJB1_SCHPO	dbl2	genetic	22681890
POF3_SCHPO	pof3	genetic	22681890
RAD5_SCHPO	rad8	genetic	24875629
RLF2_SCHPO	pcf1	genetic	25313826
YEG3_SCHPO	pcf2	genetic	25313826

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SRS2_SCHPO

Related Literatures of Post-Translational Modification