YA7D_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YA7D_SCHPO
• UniProt AC: Q09766
• Protein Name: Uncharacterized membrane protein C24H6.13
• Gene Name: SPAC24H6.13
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 871
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Acts as an osmosensitive calcium-permeable cation channel..
• Protein Sequence: MSDSSSSSTSAFVSSLVFNFAIFCAFIGLFLCLRPREKHVYQPRCIIDTQPKEEKPEPSPSSPFGLFAYVVKRSETYLIQYAGVDGYFFIRYLFTFGALCILGCLVLFPILLPVNATNGVGEKGFDILSFSNVKNHNRFYAHVFLSWLFFGFTIFIIYRELRYYVIFRHAMQSSGLYNNLPSSSTMLLTELPNSVLNDEETLHELFPNASEFTCVRDLKKLEKKVKKRSDLGNKYESTLNSLINKSVKKHNKLVKKHKPLPSTLDYTAYVKKRPTHRLKFLIGKKVDTIDYCRDTIAELDEVVDKLQTSLEERKKVGSVFIRFRSQTDLQTAYQAFLYSKKFRKYRFGRALVGIAPEDIVWSNLDLSMYTRRGKKTISNTILTLMIIFWAFPVAVVGCISNVNYLIEKVHFLKFIDHMPPKLLGIITGILPSVALSILMSLVPPFIKFLGKFGGALTVQEIENYCQNWYYAFQVVQVFLVTTMTSAATSAVVQVIKEPASSMTLLASNLPKASNFYISYFLLQGLSIPGGALLQIVTLLLSKVLGRIFDNTPRKKWNRWNQLSAPSWGTVYPVYSLLVTIMICYSIIAPIIIGFAAVAFVLIYFAYSYNLIYVLGHNADAKGRNYPRALFQVFVGLYLAEVCLIGLFVLAKNWGATVLEAVFLGFTVACHLYFKYKFLPLMDAVPISAIESVSERPEIKYPMDLGTSEMKNVGRAYPEILEKLSSSSGSDEFLETSSRTSENTKEKIDKDDEGFAITNISSVHKMPSFVLSYFSDLAASNRILTGFDRVLQLLPSFYDIPVRVRNVQYVSPALKATPPSVWIPKDPLGLSTYAIEDARGKVDIFDDNTTFNEKGNLQYTGPPPDYDEAIRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
262	Phosphorylation	KKHKPLPSTLDYTAY HHCCCCCCCCCEEEE	49.65	21712547
325	Phosphorylation	SVFIRFRSQTDLQTA CEEEEECCCCHHHHH	34.42	25720772
327	Phosphorylation	FIRFRSQTDLQTAYQ EEEECCCCHHHHHHH	39.67	25720772
724	Phosphorylation	PEILEKLSSSSGSDE HHHHHHHHCCCCCHH	38.96	25720772
725	Phosphorylation	EILEKLSSSSGSDEF HHHHHHHCCCCCHHH	38.67	28889911
726	Phosphorylation	ILEKLSSSSGSDEFL HHHHHHCCCCCHHHH	35.03	28889911
727	Phosphorylation	LEKLSSSSGSDEFLE HHHHHCCCCCHHHHH	44.24	28889911
729	Phosphorylation	KLSSSSGSDEFLETS HHHCCCCCHHHHHHC	35.60	28889911
735	Phosphorylation	GSDEFLETSSRTSEN CCHHHHHHCCCCCCC	33.86	25720772
736	Phosphorylation	SDEFLETSSRTSENT CHHHHHHCCCCCCCH	14.40	29996109
737	Phosphorylation	DEFLETSSRTSENTK HHHHHHCCCCCCCHH	47.17	28889911
739	Phosphorylation	FLETSSRTSENTKEK HHHHCCCCCCCHHHH	42.20	21712547
740	Phosphorylation	LETSSRTSENTKEKI HHHCCCCCCCHHHHC	27.95	21712547
743	Phosphorylation	SSRTSENTKEKIDKD CCCCCCCHHHHCCCC	36.21	25720772
757	Phosphorylation	DDEGFAITNISSVHK CCCCEEEEEHHHHCC	24.07	21712547
760	Phosphorylation	GFAITNISSVHKMPS CEEEEEHHHHCCCCH	28.51	28889911
761	Phosphorylation	FAITNISSVHKMPSF EEEEEHHHHCCCCHH	25.17	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YA7D_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YA7D_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YA7D_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CORO_SCHPO	crn1	genetic	18931302

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-725; SER-726; SER-727;SER-729; SER-737 AND SER-761, AND MASS SPECTROMETRY.
PubMed: 18257517